ORIGINAL_ARTICLE
The effect of mesoporous silica nanoparticles loaded with epirubicin on drug-resistant cancer cells
Objective (s): In chemotherapy for cancer treatment, the cell resistance to multiple anticancer drugs is the major clinical problem. In the present study, mesoporous silica nanoparticles (MSNs) were used as a carrier for epirubicin (EPI) in order to improve the cytotoxic efficacy of this drug against the P-glycoprotein (P-gp) overexpressing cell line. Materials and Methods: MSNs with phosphonate groups were synthesized and characterized. The cytotoxicity of the prepared nanoparticles on drug-sensitive human breast cancer cell line (MCF-7) and drug-resistant cancer cells (MCF-7/ADR) was evaluated. Results: The hydrodynamic size of nanoparticles was 98 nm and surface charge was negative. The viability of sensitive MCF-7 and resistant MCF-7/ADR cells after incubation with MSNs containing EPI at concentration of 5 μg/ml was about 75% and 44%. On the other hand, the viability of sensitive and resistant cells after incubation with free EPI at this concentration was about 48% and 60%, respectively. Conclusion: These nanoparticles exhibited suitable drug efficiencies against drug-resistant MCF-7/ADR cells in vitro experiments.
https://nmj.mums.ac.ir/article_8954_f130ec53243b9b5f4e5fdf1e02ed0edc.pdf
2017-07-01
135
141
10.22038/nmj.2017.8954
Epirubicin
Mesoporous silica nanoparticles
Multi drug resistance
P-glycoprotein
Mohammad Yahya
Hanafi-Bojd
myhanafibojd@bums.ac.ir
1
Cellular and Molecular Research Center, Department of Pharmacology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Legha
Ansari
ansaril911@mums.ac.ir
2
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Fatemeh
Mosaffa
mosaffaf@mums.ac.ir
3
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Bizhan
Malaekeh-Nikouei
malaekehb@mums.ac.ir
4
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
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60
ORIGINAL_ARTICLE
Core-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin
Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic acid (PVP-PEG-PMAA) was developed for targeted and controlled delivery of rosuvastatin. The carrier was characterized by TEM, XRD, and FT-IR techniques.Results: A typical carrier has about a 9 nm magnetite core, about 20 nm mean diameter with a narrow size distribution. The loading efficiency and pH-controlled release properties of the carrier were examined using a hydrophobic model drug rosuvastatin. Maximum loading efficiency of about 96% and a release amount of 90% of 12 hours were achieved at 37 oC in pH 1.2. While in pH 5.5 and 7.2, release amount of 25% and 37% were obtained respectively.Conclusion: The results indicate that the prepared pH-responsive polymer which covalently coated around magnetic nanoparticles is an efficient carrier with good loading capacity and controlled-release property.
https://nmj.mums.ac.ir/article_8955_cc2671cd1603817be7ee65655809f1ff.pdf
2017-07-01
142
151
10.22038/nmj.2017.8955
Drug Delivery
Magnetic Nanoparticles
Nano-carrier
pH-responsive polymer
Rosuvastatin
Mitra
Amoli-Diva
1
Department of Chemistry, Payam Noor University (PNU), Tehran, Iran
AUTHOR
Kamyar
Pourghazi
kmrpourghazi@gmail.com
2
Department of Chemistry, Karazmi (Tarbiat Moalem) University, Tehran, Iran
LEAD_AUTHOR
1.Dixit N. Floating Drug Delivery System. J Curr Pharm Res. 2012; 7(1): 6-20.
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2.Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery systems. Expert Opinion on Drug Delivery. 2006; 3(2): 217-233.
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5.Ito R, Machida Y, Sannan T, Nagai T. Magnetic granules: a novel system for specific drug delivery to esophageal mucosa in oral administration. Int J Pharm.1990; 61(1-2): 109-117.
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10.Hałupka-Bryl M, Asai K, Thangavel S, Bednarowicz M, Krzyminiewski R, Nagasaki Y. Synthesis and in vitro and in vivo evaluations of poly (ethylene glycol)-block-poly (4-vinylbenzylphosphonate) magnetic nanoparticles containing doxorubicin as a potential targeted drug delivery system. Colloid Surf B. 2014; 118: 140-147.
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11.Wang N, Guan Y, Yang L, Jia L, Wei X, Liu H, Guo C. Magnetic nanoparticles (MNPs) covalently coated by PEO-PPO-PEO block copolymer for drug delivery. J Colloid Interface Sci. 2013; 395(0): 50-57.
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12.Mashhadizadeh MH, Karami Z. Solid phase extraction of trace amounts of Ag, Cd, Cu, and Zn in environmental samples using magnetic nanoparticles coated by 3-(trimethoxysilyl)-1-propantiol and modified with 2-amino-5-mercapto-1,3,4-thiadiazole and their determination by ICP-OES. J Hazard Mater. 2011; 190(1-3): 1023-1029.
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13.Ujiie K, Kanayama N, Asai K, Kishimoto M, Ohara Y, Akashi Y, Yamada K, Hashimoto S, Oda T, Ohkohchi N, Yanagihara H, Kita E, Yamaguchi M, Fujii H, Nagasaki Y. Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles: Multi-point anchoring of PEG-b-poly (4-vinylbenzylphosphonate) improves performance significantly. Colloid Surf B. 2011; 88(2): 771-778.
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14.Abandansari HS, Nabid MR, Rezaei SJT, Niknejad H. pH-sensitive nanogels based on Boltorn® H40 and poly(vinylpyridine) using mini-emulsion polymerization for delivery of hydrophobic anticancer drugs. Polymer. 2014; 55(16): 3579-3590.
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15.Yu H, Shi X, Yu P, Zhou J, Zhang Z, Wu H, Li Y. pH-Responsive wormlike micelles for intracellular delivery of hydrophobic drugs. Journal of Controlled Release. 2013; 172(1): e33-e34.
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16.Uyar B, Celebier M Fau - Altinoz S, Altinoz S. Spectrophotometric determination of rosuvastatin calcium in tablets. Pharmazie. 2007; 62(6): 411-3.
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17.Mashhadizadeh M, Amoli-Diva M. Drug-Carrying Amino Silane Coated Magnetic Nanoparticles as Potential Vehicles for Delivery of Antibiotics. J Nanomed Nanotechol. 2012; 3: 139.
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18.Gupta S, Munjal T, Bhatia P, Kaur I. Fabrication and evaluation of Fluvatatin sodium loaded sustained release microspheres using polymer blends. Int J Pharm Pharm Sci. 2004; 6(5): 365-371.
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19.Xiao XC. Effect of the initiator on thermosensitive rate of poly (N-isopropylacrylamide) hydrogels. eXPRESS Polym Let. 2007; 1(4): 232–235.
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20.Deng KL, Zhong HB, Tian T, Gou YB, Li Q, Dong LR. Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure. eXPRESS Polym Let. 2010; 4 (12): 773–780.
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21.Zhang X, Xue L, Wang J, Liu Q, Liu J, Gao Z, Yang W. Effects of surface modification on the properties of magnetic nanoparticles/PLA composite drug carriers and in vitro controlled release study. Colloid Surf A. 2013; 431: 80-86.
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22.Yang J, Park SB, Yoon H-G, Huh YM, Haam S. Preparation of poly -caprolactone nanoparticles containing magnetite for magnetic drug carrier. Int J Pharm. 2006; 324(2): 185-190.
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23.Liu W, Selomulya C, Chen XD. Design of polymeric microparticles for pH-responsive and time-sustained drug release. Biochem EnginJ. 2014; 81: 177-186.
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25.Ding Y, Shen SZ, Sun H, Sun K, Liu F, Qi Y, Yan J. Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery. Mater Sci Engin C. 2015; 48:487-498.
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26.Barbucci R, Giani G, Fedi S, Bottari S, Casolaro M. Biohydrogels with magnetic nanoparticles as crosslinker: Characteristics and potential use for controlled antitumor drug-delivery. Acta Biomater. 2012; 8(12): 4244-4252.
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27.Namdeo M, Bajpai SK. Chitosan-magnetite nanocomposites (CMNs) as magnetic carrier particles for removal of Fe(III) from aqueous solutions. Colloid Surf A. 2008; 320(1-3): 161-168.
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28.Song H-h, Gong X, Williams GR, Quan J, Nie H-l, Zhu L-m, Nan E-l, Shao M. Self-assembled magnetic liposomes from electrospun fibers. Mater Res Bullet. 2014; 53: 280-289.
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37
ORIGINAL_ARTICLE
A novel fabrication of PVA/Alginate-Bioglass electrospun for biomedical engineering application
Objecttive (s): Polyvinylalcohol (PVA) is among the most natural polymers which have interesting properties such as nontoxic nature, biodegradability and high resistance to bacterial attacks making it applicable for tissue scaffolds, protective clothing, and wound healing.Materials and Methods: In the current work, PVA and Na-Alginate nanocomposite scaffolds were prepared using the electrospinning (ELS) technique in an aqueous solution. Also, (5% and 10%) addition of bioglass (BG) ceramic to the nanocomposite scaffold were investigated. The blended nanofibres are characterized by scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), also the bioactivity evaluation of nanocomposite scaffold performed in simulated body fluid (SBF) solutions.Results: The FTIR analysis indicated that PVA and Alginate may have H+ bonding interactions. The results revealed that with a higher amount of BG, a superior degradation as well as a higher chemical and biological stability could be obtained in the nanobiocomposite blend fibres. Furthermore, the blend nanofibre samples of 10% BG powders exhibit a significant improvement during bioactivity and mechanical testing.Conclusion: The increasing water-contact angle on the polymer surface with decreasing PVA and Alginate content indicated that the scaffold were more hydrophobic than were PVA molecules. Also, In addition, the average diameter of fibers in the sample with 10% BG have the highest porosity compared to the other scaffold samples.
https://nmj.mums.ac.ir/article_8956_89e0c2ff39f6ea31f30c50de22d70fab.pdf
2017-07-01
152
163
10.22038/nmj.2017.8956
Alginate
Bioglass
Electrospinning
Polymer
Tissue engineering
Aliasghar
Saberi
1
Department of Tissue Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
AUTHOR
Mohammad
Rafienia
m_rafienia@med.mui.ac.ir
2
Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
Elahe
Poorazizi
elahpooraziz@gmail.com
3
Department of Biochemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran
AUTHOR
1. Heydary HA, Karamian E, Poorazizi E, Heydaripour J, Khandan A. Electrospun of polymer/bioceramic nanocomposite as a new soft tissue for biomedical applications. J As Cer S. 2015; 3(4): 417-425.
1
2. Nasri-Nasrabadi B, Mehrasa M, Rafienia M, Bonakdar S, Behzad T, Gavanji S. Porous starch/cellulose nanofibers composite prepared by salt leaching technique for tissue engineering. Carbohyd polym. 2014; 108: 232-238.
2
3. Webster TJ. Nanotechnology for the regeneration of hard and soft tissues. World Scientific; 2007.
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4. Guarino V, Causa F, Taddei P, di Foggia M, Ciapetti G, Martini D, Fagnano C, Baldini N, Ambrosio L. Polylactic acid fibre-reinforced polycaprolactone scaffolds for bone tissue engineering. Biomaterials. 2008; 29(27): 3662-3670.
4
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17. Skardal A, Atala A. Biomaterials for integration with 3-D bioprinting. Ann biomed eng. 2015; 43(3): 730-746.
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18. Nazemi Z, Mehdikhani-Nahrkhalaji M, Nazarpak MH, Staji H. Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method. J Kermanshah Univ Med Sci. 2014; 18(7): 381-387.
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19. Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V, Mousavi SB, Hashemi-Beni B, Razavi SM, Akhavan A, Haghighat A. In Vivo and In Vitro Evaluation of Poly (lactide-co-glycolide)/Bioactive Glass Nanocomposite Coating. Adv Mat Res. 2014; 829: 309-313.
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20. Day RM. Bioactive glass stimulates the secretion of angiogenic growth factors and angiogenesis in vitro. Tissue Eng. 2005; 11(5): 768-777.
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21. Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin-Nazarpak M, Staji H, Kalani MM. Antibacterial activity evaluation of bioactive glass and biphasic calcium phosphate nanopowders mixtures. Appl. Phys. A. 2016 ;122(12): 1063.
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22. Koski A, Yim K, Shivkumar S. Effect of molecular weight on fibrous PVA produced by electrospinning. Materials Letters. 2004 Jan 31; 58(3): 493-497.
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23. Doustgani A, Pedram MS. Preparation and investigation of polylactic acid, calcium carbonate and polyvinylalcohol nanofibrous scaffolds for osteogenic differentiation of mesenchymal stem cells. NMJ. 2016 ;3(2): 109-114.
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24. Doustgani A. The effect of electrospun poly (lactic acid) and nanohydroxyapatite nanofibers’ diameter on proliferation and differentiation of mesenchymal stem cells. NMJ. 2016; 3(4): 217-222.
24
25. Karamian E, Motamedi MR, Khandan A, Soltani P, Maghsoudi S. An in vitro evaluation of novel NHA/zircon plasma coating on 316L stainless steel dental implant. PNS: M I. 2014; 24(2): 150-156.
25
26. Khandan A, Abdellahi M, Ozada N, Ghayour H. Study of the bioactivity, wettability and hardness behaviour of the bovine hydroxyapatite-diopside bio-nanocomposite coating. J Taiwan Ins Chem Eng. 2016; 60: 538-546.
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27. Karamian E, Abdellahi M, Khandan A, Abdellah S. Introducing the fluorine doped natural hydroxyapatite-titania nanobiocomposite ceramic. J Alloy Compd. 2016; 679: 375-383.
27
28. Kazemi A, Abdellahi M, Khajeh-Sharafabadi A, Khandan A, Ozada N. Study of in vitro bioactivity and mechanical properties of diopside nano-bioceramic synthesized by a facile method using eggshell as raw material. Mater Sci and Eng: C. 2017; 71: 604-610.
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29. Stamboulis AG, Boccaccini AR, Hench LL. Novel biodegradable polymer/bioactive glass composites for tissue engineering applications. Adv Eng Mater. 2002; 4(3): 105-109.
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30. Xu H, Lv F, Zhang Y, Yi Z, Ke Q, Wu C, Liu M, Chang J. Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing. Nanoscale. 2015; 7(44): 18446-18452.
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31. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity. Biomaterials. 2006; 27(15): 2907-2915.
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32. Khandan A, Ozada N, Karamian E. Novel Microstructure Mechanical Activated Nano Composites for Tissue Engineering Applications. J Bioeng Biomed Sci. 2015; 5(1): 1.
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33. Tolba E, Abd-Elhady BM, Elkholy B, Elkady H, Eltonsi M. Biomimetic synthesis of guided-tissue regeneration hydroxyapatite/polyvinyl alcohol nanocomposite scaffolds: influence of alginate on mechanical and biological properties. J Am Sci. 2010; 6: 239-249.
33
34. Karamian E, Khandan A, Eslami M, Gheisari H, Rafiaei N. Investigation of HA nanocrystallite size crystallographic characterizations in NHA, BHA and HA pure powders and their influence on biodegradation of HA. Adv Mat Res. 2014; 829: 314-318
34
35. Najafinezhad A, Abdellahi M, Ghayour H, Soheily A, Chami A, Khandan A. A comparative study on the synthesis mechanism, bioactivity and mechanical properties of three silicate bioceramics. Mater Sci Eng: C. 2017; 72: 259-267.
35
36. Sharafabadi AK, Abdellahi M, Kazemi A, Khandan A, Ozada N. A novel and economical route for synthesizing akermanite (Ca 2 MgSi 2 O 7) nano-bioceramic. Mater Sci Eng: C. 2017; 71: 1072-1078.
36
37. Khandan A, Abdellahi M, Barenji RV, Ozada N, Karamian E. Introducing natural hydroxyapatite-diopside (NHA-Di) nano-bioceramic coating. Ceram Int. 2015; 41(9): 12355-12363.
37
38. Taranejoo S, Janmaleki M, Rafienia M, Kamali M, Mansouri M. Chitosan microparticles loaded with exotoxin A subunit antigen for intranasal vaccination against Pseudomonas aeruginosa: an in vitro study. Carbohyd polym. 2011; 83(4): 1854-1861.
38
39.Khandan A, Karamian E, Mehdikhani-Nahrkhalaji M, Mirmohammadi H, Farzadi A, Ozada N, Heidarshenas B, Zamani K. Influence of spark plasma sintering and baghdadite powder on mechanical properties of hydroxyapatite. Proc Mat Sci. 2015; 11: 183-189.
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40.Beladi F, Saber-Samandari S, Saber-Samandari S. Cellular compatibility of nanocomposite scaffolds based on hydroxyapatite entrapped in cellulose network for bone repair. Mat Sci Eng C. 2017; 75: 385-392.
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41.Saber-Samandari S, Saber-Samandari S. Biocompatible nanocomposite scaffolds based on copolymer-grafted chitosan for bone tissue engineering with drug delivery capability. Mat Sci Eng C. 2017; 75: 721-732.
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42.Abd-Khorsand S, Saber-Samandari S, Saber-Samandari S. Development of nanocomposite scaffolds based on TiO 2 doped in grafted chitosan/hydroxyapatite by freeze drying method and evaluation of biocompatibility. Int J Biol Macromol. 2017; 101: 51-58.
42
43.Zare-Harofteh A, Saber-Samandari S, Saber-Samandari S. The effective role of akermanite on the apatite-forming ability of gelatin scaffold as a bone graft substitute. Ceram Int. 2016; 42(15): 17781-1791.
43
ORIGINAL_ARTICLE
The effect of graphite sources on preparation of Photoluminescent graphene nano-sheets for biomedical imaging
Objective(s): Graphene as two-dimensional (2D) materials have attracted wide attention in different fields such as biomedical imaging. Ultra-small graphene nano-sheets (UGNSs) have been designated as low dimensional graphene sheets with lateral dimensions less than few nanometres (≤ 500 nm) in one, two or few layers. Several studies have proven that the process of acidic exfoliation and oxidation is one of the most effective methods to synthesize low dimensional graphene sheets. The band gap of graphene can be changed through changing the reaction temperature resulting in different photoluminescent colors. The aim of our study is synthesis of multi-color photoluminescent UGNSs for biomedical imaging.Materials and Methods: Two different UGNSs were synthesized from two different graphite sources via acidic treatment with a mixture of sulfuric and nitric acids. The prepared UGNSs were characterized by UV-Vis, photoluminescent, Raman spectroscopy and scanning electron microscopy (SEM). The photoluminescence colors of the prepared UGNSs were detected under excitation wavelength of 470 nm using optical filters.Results: The results showed that the graphite primary source is a determinant factor in the synthesis of different UGNSs. While altering reaction temperature didn't significantly change the emission wavelengths; however it affected their photoluminescent emission intensity.Conclusion: Overall, nontoxic UGNSs synthesized by simple acidic treatment of graphite with different photoluminescent colors (green, yellow and red) can be a promising fluorescent probe for bioimaging.
https://nmj.mums.ac.ir/article_8957_f076aa0c2f67c948221721064cb4b404.pdf
2017-07-01
164
169
10.22038/nmj.2017.8957
Bioimaging
Graphite source
Photoluminescent
Ultra-small graphene nano-sheets
Soroush
Moasses Ghafary
soroush_moasses@yahoo.com
1
Department of Nanobiothechnology, University of Tarbiat Modares, Tehran, Iran
AUTHOR
Shadie
Hatamie
shadyhatamy@gmail.com
2
Institute for Nanoscience and Nanotechnology (INST), Sharif University of Technology,Tehran, Iran
AUTHOR
Maryam
Nikkhah
m_nikkhah@modares.ac.ir
3
Department of Nanobiothechnology, University of Tarbiat Modares, Tehran, Iran
AUTHOR
Saman
Hosseinkhani
saman_h@modares.ac.ir
4
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
LEAD_AUTHOR
1.Shen J, Zhu Y, Yang X, Li C. Graphene quantum dots: emergent nanolights for bioimaging, sensors, catalysis and photovoltaic devices. Chem Commun. 2012; 48(31): 3686-3699.
1
2.Akhavan O, Ghaderi E, Abouei E, Hatamie S, Ghasemi E. Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets. Carbon. 2014; 66: 395-406.
2
3.Hatamie S, Akhavan O, Sadrnezhaad SK, Ahadian MM, Shirolkar MM, Wang HQ. Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells. Mater Sci Eng C Mater Biol Appl. 2015; 55: 482-489.
3
4.Mahmoudifard M, Soleimani M, Hatamie S, Zamanlui S, Ranjbarvan P, Vossoughi M, Hosseinzadeh S. The different fate of satellite cells on conductive composite electrospun nanofibers with graphene and graphene oxide nanosheets. Biomed Mater. 2016; 11(2): 025006.
4
5.Eda G, Chhowalla M. Chemically derived graphene oxide: towards large‐area thin‐film electronics and optoelectronics. Adv Mater. 2010; 22(22): 2392-2415.
5
6.Zhou X, Guo S, Zhong P, Xie Y, Li Z, Ma X. Large scale production of graphene quantum dots through the reaction of graphene oxide with sodium hypochlorite. RSC Adv. 2016; 6(60): 54644-54648.
6
7.Lin L, Rong M, Luo F, Chen D, Wang Y, Chen X. Luminescent graphene quantum dots as new fluorescent materials for environmental and biological applications. TrAC. 2014; 54: 83-102.
7
8.Pan D, Guo L, Zhang J, Xi C, Xue Q, Huang H, Li J, Zhang Z, Yu W, Chen Z, Li Z. Cutting sp 2 clusters in graphene sheets into colloidal graphene quantum dots with strong green fluorescence. J Mater Chem. 2012; 22(8): 3314-3318.
8
9.Li L, Wu G, Yang G, Peng J, Zhao J, Zhu JJ. Focusing on luminescent graphene quantum dots: current status and future perspectives. Nanoscale. 2013; 5(10): 4015-4039.
9
10.Tetsuka H, Asahi R, Nagoya A, Okamoto K, Tajima I, Ohta R, Okamoto A. Optically tunable amino‐functionalized graphene quantum dots. Adv Mater. 2012; 24(39): 5333-5338.
10
11.Nigam P, Waghmode S, Louis M, Wangnoo S, Chavan P, Sarkar D. Graphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer J Mater Chem. B. 2014; 2(21): 3190-3195.
11
12.Tetsuka H, Asahi R, Nagoya A, Okamoto K, Tajima I, Ohta R, Okamoto A. Optically tunable amino‐functionalized graphene quantum dots. Adv Mater. 2012; 24(39): 5333-5338.
12
13.Nurunnabi MD, Khatun Z, Reeck GR, Lee DY, Lee YK. Near infra-red photoluminescent graphene nanoparticles greatly expand their use in noninvasive biomedical imaging. Chem Commun. 2013; 49(44): 5079-5081.
13
14.Dong Y, Chen C, Zheng X, Gao L, Cui Z, Yang H, Guo C, Chi Y, Li CM. One-step and high yield simultaneous preparation of single-and multi-layer graphene quantum dots from CX-72 carbon black. J Mater Chem. 2012; 22(18): 8764-8766.
14
15.Lin L, Zhang S. Creating water soluble luminescent graphene quantum dots via exfoliating and disintegrating carbon nanotubes and graphite flakes. Chem commun. 2012; 48(82): 10177-10179.
15
16.Peng J, Gao W, Gupta BK, Liu Z, Romero-Aburto R, Ge L, Song L, Alemany LB, Zhan X, Gao G, Vithayathil SA. Graphene quantum dots derived from carbon fibers. Nano lett. 2012; 12(2): 844-849.
16
17.Zhang Z, Zhang J, Chen N, Qu L. Graphene quantum dots: an emerging material for energy-related applications and beyond. Energy Environ Sci. 2012; 5(10): 8869-8890.
17
18.Wang Y, Hu A. Carbon quantum dots: synthesis, properties and applications. J Mater Chem. 2014; 2(34): 6921-6939.
18
19.Sekiya R, Uemura Y, Murakami H, Haino T. White‐Light‐Emitting Edge‐Functionalized Graphene Quantum Dots. Angew Chem. 2014; 53(22): 5619-5623.
19
20.Cai M, Thorpe D, Adamson DH, Schniepp HC. Methods of graphite exfoliation. J Mater Chem. 2012; 22(48): 24992-25002.
20
21.Wang S, Cole IS, Zhao D, Li Q. The dual roles of functional groups in the photoluminescence of graphene quantum dots. Nanoscale. 2016; 8(14): 7449-7458.
21
22.Ye R, Xiang C, Lin J, Peng Z, Huang K, Yan Z, Cook NP, Samuel EL, Hwang CC, Ruan G, Ceriotti G. Coal as an abundant source of graphene quantum dots. Nat Commun. 2013; 4: 2943-2948.
22
23.Qu D, Zheng M, Zhang L, Zhao H, Xie Z, Jing X, Haddad RE, Fan H, Sun Z. Formation mechanism and optimization of highly luminescent N-doped graphene quantum dots. Sci Rep. 2014; 4: 5294-5303.
23
24.Smith AM, Nie S. Semiconductor nanocrystals: structure, properties, and band gap engineering. Acc Chem Res. 2010; 43(2): 190-200.
24
25.Bailey RE, Nie S. Alloyed semiconductor quantum dots: tuning the optical properties without changing the particle size. J Am Chem Soc. 2003; 125(23): 7100-7106.
25
26.Lin L, Rong M, Luo F, Chen D, Wang Y, Chen X. Luminescent graphene quantum dots as new fluorescent materials for environmental and biological applications. TrAC. 2014; 54: 83-102.
26
27.Li L, Wu G, Yang G, Peng J, Zhao J, Zhu JJ. Focusing on luminescent graphene quantum dots: current status and future perspectives. Nanoscale. 2013; 5(10): 4015-4039.
27
28.Chua CK, Sofer Z, Simek P, Jankovský O, Klímová K, Bakardjieva S, Hrdličková Kučková S, Pumera M. Synthesis of strongly fluorescent graphene quantum dots by cage-opening buckminsterfullerene. Acs Nano. 2015; 9(3): 2548-2555.
28
ORIGINAL_ARTICLE
Cytotoxicity effects of synthesized ZnO and Zn0.97X0.03O (X=Li, Na, and K) nanoparticles by the gelatin-based sol-gel method
Objective: In this study we would like to report the synthesis of pure and group I element doping of ZnO nanoparticles (ZnO-NPs) prepared using gelatin. The use of natural polymers for the preparation of the pure and doped nanoparticles can result in achieving low cost and eco-friendly advantages.Materials and Method: Pure and doped ZnO-NPs were obtained at 500 °C and The cytotoxicity of nanoparticles was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide (MTT) assay. Briefly, neuro2A cells were seeded at a density of 1×104 cells perwellin96-wellplatesand incubatedfor24h.Thereafter, the cells were treated with various concentrations of nanoparticles in the presence of 10% FBS.Results: X-ray diffraction (XRD) analysis revealed wurtzite hexagonal structure for the prepared nanoparticles. No other peaks related to the other compounds are detected which indicate that the doped group one elements have been diffused into ZnO lattice. Field emission scanning electron microscopy (FESEM) showed that the formation of most nanoparticles in nano scale. In vitro cytotoxicity studies on neuro2A cells show the non-toxic effect of concentration below ~250 μg/mL for pure and K doped ZnONPs and ~63 μg/mL for Li and Na doped ZnO-NPs. Conclusion: The results show that the potentials of the prepared doped samples to be used in cancer treatments.
https://nmj.mums.ac.ir/article_8958_998ead091aa754634385d1163fa754fb.pdf
2017-07-01
170
176
10.22038/nmj.2017.8958
ZnO
Cytotoxicity
Zinc Oxide
Doping
Ali
Khorsand Zak
alikhorsandzak@gmail.com
1
Nanotechnology Laboratory, Esfarayen University of Technology, Esfarayen, North Khorasan, Iran
LEAD_AUTHOR
1. Hong J, He Y. Polyvinylidene fluoride ultrafiltration membrane blended with nano-ZnO particle for photo-catalysis self-cleaning. Desalination. 2014; 332(1): 67-75.
1
2.Soumya S, Mohamed AP, Mohan K, Ananthakumar S. Enhanced near-infrared reflectance and functional characteristics of Al-doped ZnO nano-pigments embedded PMMA coatings. Sol Energy Mater Sol Cells. 2015; 143: 335-46.
2
3. Vanalakar SA, Patil VL, Harale NS, Vhanalakar SA, Gang MG, Kim JY, Patil PS, Kim JH. Controlled growth of ZnO nanorod arrays via wet chemical route for NO2 gas sensor applications. Sensors and Actuators B: Chemical. 2015; 221: 1195-201.
3
4. Petkova P, Francesko A, Perelshtein I, Gedanken A, Tzanov T. Simultaneous sonochemical-enzymatic coating of medical textiles with antibacterial ZnO nanoparticles. Ultrason Sonochem. 2016; 29: 244-50.
4
5. Yin H, Casey PS. ZnO nanorod composite with quenched photoactivity for UV protection application. Mater Lett. 2014; 121: 8-11.
5
6. Yousefi R, Muhamad MR, Zak AK. Investigation of indium oxide as a self-catalyst in ZnO/ZnInO heterostructure nanowires growth. Thin Solid Films. 2010; 518(21): 5971-7.
6
7.Yousefi R, Zak AK, Jamali-Sheini F. Growth, X-ray peak broadening studies, and optical properties of Mg-doped ZnO nanoparticles. Mater Sci Semicond Process. 2013; 16(3): 771-7.
7
8.Yousefi R, Zak AK, Mahmoudian M. Growth and characterization of Cl-doped ZnO hexagonal nanodisks. J Solid State Chem. 2011; 184(10): 2678-82.
8
9.Zak AK, Huang NM. Optical properties of group-I-doped ZnO nanowires. Ceram Int. 2014; 40: 4327-32.
9
10.Zak AK, Majid WA, Abrishami ME, Yousefi R, Parvizi R. Synthesis, magnetic properties and X-ray analysis of Zn0. 97X0. 03O nanoparticles (X= Mn, Ni, and Co) using Scherrer and sizeestrain plot methods. Solid State Sciences. 2012; 14(4): 488-94.
10
11.Saidani T, Zaabat M, Aida MS, Boudine B. Effect of copper doping on the photocatalytic activity of ZnO thin films prepared by sol–gel method. Superlattices Microstruct. 2015; 88: 315-22.
11
12.Feng W, Huang P, Wang B, Wang C, Wang W, Wang T, Chen S, Lv R, Qin Y, Ma J. Solvothermal synthesis of ZnO with different morphologies in dimethylacetamide media. Ceram Int. 2016; 42(2, Part A): 2250-6.
12
13. Razali R, Zak AK, Majid WA, Darroudi M. Solvothermal synthesis of microsphere ZnO nanostructures in DEA media. Ceram Int. 2011; 37(8): 3657-63.
13
14. Suntako R. Effect of synthesized ZnO nanograins using a precipitation method for the enhanced cushion rubber properties. Mater Lett. 2015; 158: 399-402.
14
15.Zak AK, Wang H, Yousefi R, Golsheikh AM, Ren Z. Sonochemical synthesis of hierarchical ZnO nanostructures. Ultrason Sonochem. 2013; 20(1): 395-400.
15
16. Yousefi R, Jamali‐Sheini F, Zak AK. A comparative study of the properties of ZnO nano/microstructures grown using two types of thermal evaporation set‐up conditions. Chem Vap Deposition. 2012; 18(7‐9): 215-20.
16
17. Xu X, Zhou M. Antimicrobial gelatin nanofibers containing silver nanoparticles. Fibers and polymers. 2008; 9(6): 685-90.
17
18. Ahmed F, Arshi N, Dwivedi S, Koo BH, Azam A, Alsharaeh E. Low temperature growth of ZnO nanotubes for fluorescence quenching detection of DNA. J Mater Sci Mater Med. 2016; 27(12): 189.
18
19.Nair S, Sasidharan A, Divya Rani VV, Menon D, Nair S, Manzoor K, Raina S. Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. J Mater Sci Mater Med. 2008; 20(1): 235.
19
20.Ohira T, Yamamoto O, Iida Y, Nakagawa Z-e. Antibacterial activity of ZnO powder with crystallographic orientation. J Mater Sci Mater Med. 2008; 19(3): 1407-12.
20
21. Wang S, Wu J, Yang H, Liu X, Huang Q, Lu Z. Antibacterial activity and mechanism of Ag/ZnO nanocomposite against anaerobic oral pathogen Streptococcus mutans. J Mater Sci Mater Med. 2017; 28(1): 23.
21
22. Park S, Lee YK, Jung M, Kim KH, Chung N, Ahn E-K, Lim Y, Lee K-H. Cellular toxicity of various inhalable metal nanoparticles on human alveolar epithelial cells. Inhal Toxicol. 2007; 19(sup1): 59-65.
22
23.Soto KF, Carrasco A, Powell TG, Murr LE, Garza KM. Biological effects of nanoparticulate materials. Materials Science and Engineering: C. 2006; 26(8): 1421-7.
23
24.Nie L, Gao L, Feng P, Zhang J, Fu X, Liu Y, Yan X, Wang T. Three‐Dimensional Functionalized Tetrapod‐like ZnO Nanostructures for Plasmid DNA Delivery. Small. 2006; 2(5): 621-5.
24
25.Vandebriel RJ, De Jong WH. A review of mammalian toxicity of ZnO nanoparticles. Nanotechnology, science and applications. 2012; 5: 61.
25
26.Wang L, Wang L, Ding W, Zhang F. Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. Journal of nanoscience and nanotechnology. 2010; 10(12): 8617-24.
26
27.Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1): 55-63.
27
28.Darroudi M, Sabouri Z, Oskuee RK, Zak AK, Kargar H, Hamid MHNA. Green chemistry approach for the synthesis of ZnO nanopowders and their cytotoxic effects. Ceram Int. 2014; 40(3): 4827-31.
28
29. Baek M, Kim MK, Cho HJ, Lee JA, Yu J, Chung HE, Choi SJ. Factors influencing the cytotoxicity of zinc oxide nanoparticles: particle size and surface charge. Journal of Physics: Conference Series. 2011; 304(1): 012044.
29
30.Hanley C, Thurber A, Hanna C, Punnoose A, Zhang J, Wingett DG. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale research letters. 2009; 4(12): 1409-20.
30
31.Hsiao I-L, Huang Y-J. Effects of various physicochemical characteristics on the toxicities of ZnO and TiO 2 nanoparticles toward human lung epithelial cells. Sci Total Environ. 2011; 409(7): 1219-28.
31
32.H. Müller K, Kulkarni J, Motskin M, Goode A, Winship P, Skepper JN, Ryan MP, Porter AE. pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution. ACS nano. 2010; 4(11): 6767-79.
32
33.Heng BC, Zhao X, Xiong S, Ng KW, Boey FY-C, Loo JS-C. Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format. Arch Toxicol. 2011; 85(6): 695-704.
33
34.Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine: Nanotechnology, Biology and Medicine. 2011; 7(2): 184-92.
34
35. Taccola L, Raffa V, Riggio C, Vittorio O, Iorio MC, Vanacore R, Pietrabissa A, Cuschieri A. Zinc oxide nanoparticles as selective killers of proliferating cells. Int J Nanomed. 2011; 6: 1129-40.
35
36.Akhtar MJ, Ahamed M, Kumar S, Khan MM, Ahmad J, Alrokayan SA. Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. International journal of nanomedicine. 2012; 7: 845.
36
ORIGINAL_ARTICLE
Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique
Objecttive (s): Silicate bioceramics like Baghdadite with chemical formula Ca3ZrSi2O9, has attracted the attention of researchers in biomedical field due to its remarkable in-vitro and in-vivo bioactivity and mechanical properties.Materials and Methods: Therefore, in the current study the baghdadite powder with Sol-Gel method was synthesized. Then, hydroxyapatite/Baghdadite (HA/Bagh) scaffolds were prepared by the replacing the polyurethane polymeric sponge technique. Afterwhile, the ceramic scaffolds were sintered at 1150ºC for 3 h. The prepared scaffold was then coated by polycaprolactone/bioglass (PCL/BG) polymer nanocomposite. Results: Bioactivity and biomineralization in the simulated body fluid (SBF) revealed that the nanocomposite scaffolds coate with PCL/BG had significant bioactivity properties. The morophology and microstructure investigation of soaked samples in SBF indicate that bone-like apatite formed on the surfaces. Also, ion release in SBF containing the scaffolds was measured by inductively coupled plasma (ICP) analysis. The nucleation positions of apatite crystals were areas with high silicon containing, Si+4 ion positions.Conclusion: The study indicates that scaffold containing 30 wt. % baghdadite had proper bioactivity behaviordue to its ability to form bone-like apatite on the surface of specimens.
https://nmj.mums.ac.ir/article_8959_6e74748fd9f7ad1dd7b20db746f49618.pdf
2017-07-01
177
183
10.22038/nmj.2017.8959
Coating
Nanocomposite
Polymer
Polyurethane polymeric sponge technique
Scaffolds
Ebrahim
Karamian
1
Advanced Materials Research Center, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
AUTHOR
Akram
Nasehi
akramnasehi21@yahoo.com
2
Advanced Materials Research Center, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
AUTHOR
Saeed
Saber-Samandari
3
New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran
AUTHOR
Amirsalar
Khandan
amir_salar_khandan@yahoo.com
4
Young Researchers and Elite Club, Khomeinishahr Branch, Islamic Azad University, Isfahan, Iran
LEAD_AUTHOR
1. Karamian E, Khandan A, Eslami M, Gheisari H, Rafiaei N. Investigation of HA nanocrystallite size crystallographic characterizations in NHA, BHA and HA pure powders and their influence on biodegradation of HA. Adv Mat Res. 2014; 829: 314-318.
1
2. Boudriot U, Goetz B, Dersch R, Greiner A, Wendorff JH. Role of electrospun nanofibers in stem cell technologies and tissue engineering. Macromol Chem Phys. 2005; 225 (1): 9-16.
2
3. Kariem H, Pastrama MI, Roohani-Esfahani SI, Pivonka P, Zreiqat H, Hellmich C. Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: a unifying approach based on ultrasonics, nanoindentation, and homogenization theory. Mat Sci Eng C-Mater. 2015; 46:553-564.
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5. Laurencin CT, Nair LS, editors. Nanotechnology and regenerative engineering: the scaffold. CRC Press; 2014.
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6. Pangon A, Saesoo S, Saengkrit N, Ruktanonchai U, Intasanta V. Hydroxyapatite-hybridized chitosan/chitin whisker bionanocomposite fibers for bone tissue engineering applications. Carbohyd Polym. 2016; 144: 419-427.
6
7. Ramaswamy Y, Wu C, Zhou H, Zreiqat H. Biological response of human bone cells to zinc-modified Ca–Si-based ceramics. Acta Biomater. 2008; 4(5): 1487-1497.
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8. Kwong FN, Harris MB. Recent developments in the biology of fracture repair. J Am Acad Orthop Sur. 2008; 16(11): 619-625.
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9. Tabata Y. Recent progress in tissue engineering. Drug discov today. 2001; 6(9):483-487.
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10. Chu SJ, Salama MA, Garber DA, Salama H, Sarnachiaro GO, Sarnachiaro E, Gotta SL, Reynolds MA, Saito H, Tarnow DP. Flapless postextraction socket implant placement, part 2: the effects of bone grafting and provisional restoration on peri-implant soft tissue height and thickness-a retrospective study. Int J Periodontics Restorative Dent. 2015; 35(6):803-809.
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11. Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: an update. Injury. 2005; 36(3): S20-7.
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12. Hutmacher DW, Schantz JT, Lam CX, Tan KC, Lim TC. State of the art and future directions of scaffold‐based bone engineering from a biomaterials perspective. J tissue eng regen m. 2007; 1(4): 245-260.
12
13. Kumar PR, Sreenivasan K, Kumary TV. Alternate method for grafting thermoresponsive polymer for transferring in vitro cell sheet structures. J Appl Polym Sci. 2007; 105(4): 2245-2251.
13
14. Karamian E, Motamedi MR, Khandan A, Soltani P, Maghsoudi S. An in vitro evaluation of novel NHA/zircon plasma coating on 316L stainless steel dental implant. Prog Nat Sci-Mater. 2014; 24(2): 150-156.
14
15. Karamian E, Khandan A, Kalantar Motamedi MR, Mirmohammadi H. Surface characteristics and bioactivity of a novel natural HA/zircon nanocomposite coated on dental implants. Biomed Res Int. 2014.
15
16. Khandan A, Abdellahi M, Ozada N, Ghayour H. Study of the bioactivity, wettability and hardness behaviour of the bovine hydroxyapatite-diopside bio-nanocomposite coating. J Taiwan Inst Chem E. 2016; 60: 538-546.
16
17. Park HJ, Yu SJ, Yang K, Jin Y, Cho AN, Kim J, Lee B, Yang HS, Im SG, Cho SW. Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering. Biomaterials. 2014; 35(37): 9811-9823.
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18. Komlev VS, Barinov SM. Porous hydroxyapatite ceramics of bi-modal pore size distribution. J Mater Sci-Mater M. 2002; 13(3): 295-299.
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19. Baino F, Caddeo S, Novajra G, Vitale-Brovarone C. Using porous bioceramic scaffolds to model healthy and osteoporotic bone. J Eur Ceram Soc. 2016; 36(9): 2175-2182.
19
20. Esfahani SR, Tavangarian F, Emadi R. Nanostructured bioactive glass coating on porous hydroxyapatite scaffold for strength enhancement. Mater Lett. 2008; 62(19):3428-3430.
20
21. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005; 26(27): 5474-5491.
21
22. Khandan A, Karamian E, Mehdikhani-Nahrkhalaji M, Mirmohammadi H, Farzadi A, Ozada N, Heidarshenas B, Zamani K. Influence of spark plasma sintering and baghdadite powder on mechanical properties of hydroxyapatite. Proc Mat Sci. 2015 ;11: 183-189.
22
23. Khandan A, Abdellahi M, Barenji RV, Ozada N, Karamian E. Introducing natural hydroxyapatite-diopside (NHA-Di) nano-bioceramic coating. Ceram Int. 2015; 41(9): 12355-12363.
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24. Khandan A, Karamian E, Bonakdarchian M. Mechanochemical synthesis evaluation of nanocrystalline bone-derived bioceramic powder using for bone tissue engineering. Dent Hypo. 2014; 5(4): 155.
24
25. Karamian E, Abdellahi M, Khandan A, Abdellah S. Introducing the fluorine doped natural hydroxyapatite-titania nanobiocomposite ceramic. J Alloy Compd. 2016; 679: 375-83.
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26. Sadeghpour S, Amirjani A, Hafezi M, Zamanian A. Fabrication of a novel nanostructured calcium zirconium silicate scaffolds prepared by a freeze-casting method for bone tissue engineering. Ceram Int. 2014; 40(10): 16107-16114.
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27. Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006; 27(9): 1728-1734.
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28. Sopyan I, Mel M, Ramesh S, Khalid KA. Porous hydroxyapatite for artificial bone applications. Sci Technol Adv Mat. 2007; 8(1): 116-123.
28
29. Heydary HA, Karamian E, Poorazizi E, Heydaripour J, Khandan A. Electrospun of polymer/bioceramic nanocomposite as a new soft tissue for biomedical applications. J As Cer S. 2015; 3(4): 417-425.
29
30. An SH, Matsumoto T, Miyajima H, Nakahira A, Kim KH, Imazato S. Porous zirconia/hydroxyapatite scaffolds for bone reconstruction. Dent Mater. 2012; 28(12): 1221-1231.
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31. De Aza PN, Luklinska ZB, Martinez A, Anseau MR, Guitian F, De Aza S. Morphological and structural study of pseudowollastonite implants in bone. J Microsc-Oxford. 2000; 197(1): 60-67.
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32. Sadeghzade S, Emadi R, Tavangarian F. Combustion assisted synthesis of hardystonite nanopowder. Ceram Int. 2016; 42(13): 14656-14660.
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33. Wang G, Lu Z, Dwarte D, Zreiqat H. Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Mat Sci Eng C-Mater. 2012; 32(7): 1818-1826.
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34. Sadeghzade S, Emadi R, Labbaf S. Formation mechanism of nano-hardystonite powder prepared by mechanochemical synthesis. Adv Powder Technol. 2016; 27(5): 2238-44.
34
35. Abdellahi M, Najafinejad AA, Ghayour H, Saber-Samandari S, Khandan A. Preparing diopside scaffolds via space holder method: Simulation of the compressive strength and porosity. J MECH BEHAV BIOMED. 2017; 72: 171-181.
35
36. Najafinezhad A, Abdellahi M, Ghayour H, Soheily A, Chami A, Khandan A. A comparative study on the synthesis mechanism, bioactivity and mechanical properties of three silicate bioceramics. Mat Sci Eng C-Mater. 2017; 72: 259-267.
36
37. Khandan A, Ozada N, Karamian E. Novel Microstructure Mechanical Activated Nano Composites for Tissue Engineering Applications. J of Bioeng & Biomed Sci. 2015; 5(1):1.
37
38. Doustgani A. The effect of electrospun poly (lactic acid) and nanohydroxyapatite nanofibers’ diameter on proliferation and differentiation of mesenchymal stem cells. Nanomed J. 2016; 3(4): 217-222.
38
39. Saber-Samandari S, Gross KA. Micromechanical properties of single crystal hydroxyapatite by nanoindentation. Acta Biomater. 2009; 5(6): 2206-2212.
39
40. Saber-Samandari S, Gross KA. Nanoindentation reveals mechanical properties within thermally sprayed hydroxyapatite coatings. Surf Coat Tech. 2009; 203(12): 1660-1664.
40
41. Saber-Samandari S, Alamara K, Saber-Samandari S. Calcium phosphate coatings: Morphology, micro-structure and mechanical properties. Ceram Int. 2014; 40(1): 563-572.
41
ORIGINAL_ARTICLE
Antimicrobial effects of green synthesized silver nanoparticles using Melissa officinalis grown under in vitro condition
Objective(s): To evaluate the biosynthesis of Ag NPs using plant extract of Melissa officinalis (at the eight leaf stage) grown under in vitro (controlled) condition for the first time.Materials and Methods: Biosynthesis of Ag NPs using plant extract was carried out and formation of Ag NPs confirmed by UV-Visible spectroscopy, X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM) and Dynamic Light Scattering (DLS). The functional groups of compounds adsorbed on the Ag NPs were identified using Fourier Transform Infrared Spectroscop (FTIR) studies. The antibacterial activity of the Ag NPs was investigated by agar disc diffusion method.Results: The plant extract showed color change in extract from yellow to brown after formation of Ag NPs. The surface Plasmon resonance found at 450 nm confirmed the formation of Ag NPs. FESEM images revealed relatively spherical- shaped of Ag NPs. The biosynthesized Ag NPs were crystalline in nature with mean diameter about 34.64 nm. FTIR results expounded the functional groups of plant extract responsible for the bio-reduction of silver ions and their interaction between them. The obtained nanoparticles showed good inhibitory activity against the Gram positive and Gram negative bacteria.Conclusion: These results suggested that with changes in plants culture condition it may be possible to obtain nanoparticles with desired characteristics.
https://nmj.mums.ac.ir/article_8960_9e8fc04f9d33dc3a52ddaa35a85b9da3.pdf
2017-07-01
184
190
10.22038/nmj.2017.8960
Bactericidal effects
Biosynthesis
In vitro culture
Melissa officinalis
Silver nanoparticles
Saba
Pirtarighat
s.pirtarighat@gmail.com
1
Department of Biotechnology, Imam Khomeini International University (IKIU), Qazvin, Iran
AUTHOR
Maryam
Ghannadnia
ghannadnia_ma@yahoo.com
2
Department of Biotechnology, Imam Khomeini International University (IKIU), Qazvin, Iran
LEAD_AUTHOR
Saeid
Baghshahi
3
Department of Materials Engineering, Imam Khomeini International University (IKIU), Qazvin, Iran
AUTHOR
1. Goodsell DS. Bionanotechnology:lessons from nature. John Wiley & Sons, INC., publication, 2004; New Jersey, USA.
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2. Gilaki M. Biosynthesis of silver nanoparticles using plant extracts. J Biol Sci. 2010; 10(5): 465-7.
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4. Leela A, Vivekanandan M. Tapping the unexploited plant resources for the synthesis of silver nanoparticles. Afr. J. Biotechnol. 2008;7(17): 3162-3165.
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11. Gonçalves S, Romano A. In vitro culture of lavenders (Lavandula spp.) and the production of secondary metabolites. Biotechnol. Adv. 2013; 31(2): 166-174.
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12. Moradkhani H, Sargsyan E, Bibak H, Naseri B, Sadat-Hosseini M, Fayazi-Barjin A, Meftahizade H. Melissa officinalis L., a valuable medicine plant: A. J Med Plants Res. 2010;(4): 2753-2759.
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13. Zielińska A, Skwarek E, Zaleska A, Gazda M, Hupka J. Preparation of silver nanoparticles with controlled particle size. Procedia Chem. 2009; 1(2): 1560-1566.
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14. Hahn H. Unique features and properties of nanostructured materials. Adv. Eng. Mater. 2003; 5(5): 277-284.
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15. Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M. Synthesis of gold nanotriangles and silver nanoparticles using Aloevera plant extract. Biotechnol. Prog. 2006; 22(2): 577-583.
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16. Kumar P, Selvi SS, Govindaraju M. Seaweed-mediated biosynthesis of silver nanoparticles using Gracilaria corticata for its antifungal activity against Candida spp. Appl. Nanosci. 2013;3(6):495-500.
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17. Raut Rajesh W, Lakkakula Jaya R, Kolekar Niranjan S, Mendhulkar Vijay D, Kashid Sahebrao B. Phytosynthesis of silver nanoparticle using Gliricidia sepium (Jacq.). Curr. Nanosc. 2009; 5(1): 117-122.
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18. Fayaz AM, Balaji K, Kalaichelvan P, Venkatesan R. Fungal based synthesis of silver nanoparticles—an effect of temperature on the size of particles. Colloids Surf., B. 2009; 74(1): 123-126.
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19. Vanaja M, Gnanajobitha G, Paulkumar K, Rajeshkumar S, Malarkodi C, Annadurai G. Phytosynthesis of silver nanoparticles by Cissus quadrangularis: influence of physicochemical factors. J. Nanostruct. Chem. 2013; 3(1): 1-8.
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20. Suresh S, Karthikeyan S, Jayamoorthy K. FTIR and multivariate analysis to study the effect of bulk and nano copper oxide on peanut plant leaves. J. Sci. Adv. Mater. Devices. 2016; 1(3): 343-350.
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21. Rajasekar P, Priyadharshini S, Rajarajeshwari T, Shivashri C. Bio-inspired synthesis of silver nanoparticles using Andrographis paniculata whole plant extract and their antimicrobial activity overpathogenic microbes. Int. J. Adv. Biotechnol. Res. 2013;3(3): 47-52.
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22. Raghunandan D, Bedre MD, Basavaraja S, Sawle B, Manjunath S, Venkataraman A. Rapid biosynthesis of irregular shaped gold nanoparticles from macerated aqueous extracellular dried clove buds (Syzygium aromaticum) solution. Colloids Surf., B. 2010;79(1): 235-240.
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24. Mamadalieva NZ, Akramov DK, Ovidi E, Tiezzi A, Nahar L, Azimova SS, Sarker S-D. Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities. Medicines. 2017;4(1): 8.
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25. Naidoo Y, Sadashiva C, Naidoo G, Raghu K. Antibacterial, antioxidant and phytochemical properties of the ethanolic extract of Ocimum obovatum E. Mey. ex Benth. IJTK. 2016; 15(1): 57-61.
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28. Hajipour MJ, Fromm KM, Ashkarran AA, de Aberasturi DJ, de Larramendi IR, Rojo T, Serpooshan V, Parak W, Mahmoudi M. Antibacterial properties of nanoparticles. Trends Biotechnol. 2012; 30(10): 499-511.
28
29. Chang T-Y, Chen C-C, Cheng K-M, Chin C-Y, Chen Y-H, Chen X-A, Sun J-R, Young J-J, Chiueh T-T. Trimethyl chitosan-capped silver nanoparticles with positive surface charge: Their catalytic activity and antibacterial spectrum including multidrug-resistant strains of Acinetobacter baumannii. Colloids Surf., B. 2017; 155: 61-70.
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30. Maliszewska I, Sadowski Z, editors. Synthesis and antibacterial activity of silver nanoparticles. J. Phys.: Conf. Ser. 2009: IOP Publishing.
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31. Umashankari J, Inbakandan D, Ajithkumar TT, Balasubramanian T. Mangrove plant, Rhizophora mucronata (Lamk, 1804) mediated one pot green synthesis of silver nanoparticles and its antibacterial activity against aquatic pathogens. Aquat. Biosyst. 2012; 8(1): 1-8.
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33. Kandasamy K, Alikunhi NM, Manickaswami G, Nabikhan A, Ayyavu G. Synthesis of silver nanoparticles by coastal plant Prosopis chilensis (L.) and their efficacy in controlling vibriosis in shrimp Penaeus monodon. Appl. Nanosci. 2013; 3(1): 65-73.
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35. Kumar V, Yadav SK. Plant‐mediated synthesis of silver and gold nanoparticles and their applications. J. Chem. Technol. Biotechnol. 2009; 84(2): 151-7.
35
ORIGINAL_ARTICLE
Synthesis and characterization of CdO/GrO nanolayer for in vivo imaging
Objective(s): Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yielding improved sensitivity. Nanoparticles have enabled significant advances in pre-clinical cancer research as drug delivery vectors. Inorganic nanoparticles such as CdO/GrO nanoparticles have novel optical properties that can be used to optimize the signal-to-background ratio. This paper reports on a novel processing route for preparation of CdO/GrO nanolayer and investigation of its optical properties for application in in vivo targeting and imaging.Materials and Methods: Nanostructures were synthesized by reacting cadmium acetate and graphene powder. The effects ofdifferent parameters such as power and time of irradiation were also studied. Finally, the efficiency of CdO/GrO nanostructures as an optical composite was investigated using photoluminescence spectrum irradiation. CdO/GrO nanostructures were characterized by means of X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) and photoluminescence (PL) spectroscopy.Results: According to SEM images, it was found that sublimation temperature had significant effect on morphology and layers. The spectrum shows an emission peak at 523 nm, indicating that CdO/GrO nanolayer can be used for in vivo imaging.Conclusion: The estimated optical band gap energy is an accepted value for application in in vivo imaging using a QD–CdO/GrO nanolayer.
https://nmj.mums.ac.ir/article_8961_42e1f1988e03ec34fced013e24518784.pdf
2017-07-01
191
196
10.22038/nmj.2017.8961
CdO/GrO
Hexagonal nanostructures
In vivo targeting
Optical investigation
Abbas
Pardakhty
drpardakhti@yahoo.com
1
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad Mehdi
Foroughi
2
Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran
AUTHOR
Mehdi
Ranjbar
ranjbarmehdi67@yahoo.com
3
Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran
LEAD_AUTHOR
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