TY - JOUR ID - 16705 TI - Mycosynthesis and characterization of selenium nanoparticles using standard penicillium chrysogenum PTCC 5031 and their antibacterial activity: A novel approach in microbial nanotechnology JO - Nanomedicine Journal JA - NMJ LA - en SN - 2322-3049 AU - Vahidi, Hossein AU - Kobarfard, Farzad AU - Kosar, Zahra AU - Mahjoub, Mohammad Ali AU - Saravanan, Muthupandian AU - Barabadi, Hamed AD - Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia Y1 - 2020 PY - 2020 VL - 7 IS - 4 SP - 315 EP - 323 KW - Antibacterial activity KW - Biosynthesis KW - Nanobiotechnology KW - Selenium nanoparticles DO - 10.22038/nmj.2020.07.00008 N2 - Objective(s): This study deals with mycosynthesis and characterization of selenium nanoparticles (SeNPs) using the Penicillium chrysogenum PTCC 5031 and evaluating their antibacterial activity. Materials and Methods: The formation of SeNPs was confirmed with the color change from pale yellow to orange. Tyndall effect also confirmed the formation of colloidal systems through the samples. The SeNPs were characterized using different analytical techniques including photon correlation spectroscopy (PCS), Scanning Electron Microscope (SEM), Atomic Force Microscope (AFM), Energy Dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier Transform Infrared (FT-IR) analysis.Results: Our findings revealed that SeNPs were fairly uniformed with good monodispersity and the lesser aggregation of particles in pH value of 7 with the average hydrodynamic size of 24.65 nm, polydispersity index (PdI) of 0.392 and zeta potential of -34 mV. The SeNPs revealed antibacterial activity against gram positive bacteria including Staphylococcus aureus, and Listeria monocytogenes with the zone of inhibition (ZOI) of 10 and 13 mm, respectively. Conclusion: The results of this study provided a potential solution to the growing need for the development of cost-effective and eco-friendly ways of nanoparticle synthesis to overcome the microbial resistance and control the infectious diseases. However, further investigations are required to demonstrate the efficacy of SeNPs through in vivo models. UR - https://nmj.mums.ac.ir/article_16705.html L1 - https://nmj.mums.ac.ir/article_16705_091fa1ba311b772e2ffccfc96ac63d9a.pdf ER -