Biosynthesis of Srco3 nanostructures with honey as a green capping agent and reductant: photodynamic therapy

Document Type: Research Paper

Authors

1 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

2 Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

3 Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Objective (s): SrCO3 nanoparticles could be used as new biomedical sources in magnetic resonance imaging as a promising noninvasive imaging modality for the preoperative staging of breast cancer and monitoring of tumor response to therapy. The present study aimed to synthesize SrCO3 nanostructures using microwave irradiation in the presence of honey as a green capping agent and reductant.
Materials and Methods: The optical properties of SrCO3 nanostructures were investigated using ultraviolet-visible (UV-Vis) spectroscopy. Sr(NO3)2.6H2O and NaOH were applied as the starting reagents. Fructose (32.56-38.2%) and glucose (28.54-31.3%), which were the main carbohydrates found in honey, were not only involved in stabilization, but they also acted as the reducing agents in the production of SrCO3 nanostructures. The produced nanostructures were characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy.
Results: Method of synthesis and chemical reagents were observed to affect the structural parameters, crystallite size, product size, morphology, and antioxidant activity.
Conclusion: According to the results, honey could be used as a green capping agent and reductant for the synthesis of SrCO3 nanostructures as a novel structure to co-deliver therapeutic agents using photo-thermal agents. Moreover, honey has significant potential for diagnostic and therapeutic purposes in the future.

Keywords


1.Lucky S S, Soo KC, Zhang Y, Nanoparticles in photodynamic therapy. Chem Rev. 2015 ; 115 (4): 1990-2042.
2.Park YI, Kim H, Kyung C, Byeongjun Y, Kang L, Nohyun L, Yoonseok C, Wooram P, Daishun L, Kun N, Woo K, Moon S, Hong C, Hong S, Park S, Young Y, Yung Doug S, Sung H, Taeghwan H, Theranostic probe based on lanthanide‐doped nanoparticles for simultaneous in vivo dual‐modal imaging and photodynamic therapy. Adv Mater. 2012; 24(24): 5755-5761.
3.Bechet D, Serge RM, François G, Muriel A B, Photodynamic therapy of malignant brain tumours: a complementary approach to conventional therapies. Cancer Treat Res. 2014; 40(2): 229-241.
4.Punjabi A, Xiang W, Amira T, Mahmoud E, Hyungseok L, Yuanwei Z, Chao W, Zhuang L, Emory M. C, Chunying D, Gang H, Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy. ACS nano. 2014; 8(10): 10621-10630.
5.Xu K, Yao H, Jinhui H, Zhou L, Zhou S, Pre-drug Self-assembled Nanoparticles: Recovering activity and overcoming glutathione-associated cell antioxidant resistance against photodynamic therapy. Free Radic Biol Med. 2018; 124(20): 431-446.
6.Youssef Z, Valérie H, Ludovic C, Philippe A, Moussaron A, Baros F, Toufaily J, Hamieh T, Carmes T, Frochot C, Titania and silica nanoparticles coupled to Chlorin e6 for anti-cancer photodynamic therapy. Free Radic Res. 2018; 22(6): 115-126.
7.Gamaleia N F, Shton I O, Gold mining for PDT: Great expectations from tiny nanoparticles. Photodiagnosis Photodyn Ther. 2015; 12(2): 221-231.
8.Moritz M N O, Joyce L S, Gonçalves I, Linares J, Kleber T , Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative. Photodiagnosis Photodyn Ther. 2017; 17(3): 39-47.
9.Oniszczuk A, Karolina A, Wojtunik K, Tomasz O, Kamila K, Show M, The potential of photodynamic therapy (PDT)—Experimental investigations and clinical use. ‎Biomed. Pharmacother. 2016; 83(4): 912-929.
10.Liu Y, Meng X, Bu W, Upconversion-based photodynamic cancer therapy. COORDIN CHEM REV. 2019; 379(15): 82-98.
11.Yurt F, MineInce S, Gokhan Colak, Kasim O, Ozge E, Hale M, Soylu C, Gunduz B, Avci C, Caliskan K, Investigation of in vitro PDT activities of zinc phthalocyanine immobilised TiO2 nanoparticles. Int J Pharm.2017; 524(15): 467-474.
12.Nyanhongo G S, Christoph S, Roland L, Nugroho P, Georg M.G, An antioxidant regenerating system for continuous quenching of free radicals in chronic wounds. Eur J Pharm Biopharm. 2013; 83(3): 396-404.
13.Prior R.L, Oxygen radical absorbance capacity (ORAC): New horizons in relating dietary antioxidants/bioactives and health benefits. J FUNCT FOODS. 2015; 18(3): 797-810.
14.Trivittayasil V, Hiromi K, Toshihiko S, Mizuki T, Mito K, Junichi S, Simultaneous estimation of scavenging capacities of peach extract for multiple reactive oxygen species by fluorescence fingerprint method.Food Chem. 2017; 232(1): 523-530.
15.O’Mahoney P,Neil H, Kenny W, Tom A, Browne S, Ewan E, Show M, A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy. Photodiagnosis Photodyn Ther. 2018; 23(34): 144-150.
16.Vignion-DewalleA.-S, Gregory B, EliseT, Claire V, Laurent M, Serge M, Show M, Photodynamic therapy for actinic keratosis: Is the European consensus protocol for daylight PDT superior to conventional protocol for Aktilite CL 128 PDT, J. Photochem. Photobiol. 2017; 174(3): 70-77.
17.DaiY,Xiuli Z, Yanying Hu, Zhang Y,Liu M, Quantum chemical calculation of free radical substitution reaction mechanism of camptothecin. J Mol Graph Model. 2018; 84 (2): 174-181.
18.Mason R P, and Ganini D, Immuno-spin trapping of macromolecules free radicals in vitro and in vivo – One stop shopping for free radical detection. Free Radic Biol Med. 2019; 131(1): 318-331.
19.Niu N, Zhe Z, Xiao Z, Chen S, Photodynamic therapy in hypoxia: Near-infrared-sensitive, self-supported, oxygen generation nano-platform enabled by upconverting nanoparticles. Chem Eng J.2018; 352(15): 818-827.
20.Wysocka-Król K, Olsztyńska S, Janus G, Plesch A, Plecenik H, Podbielska J, , Nano-silver modified silica particles in antibacterial photodynamic therapy. Appl Surf Sci. 2018; 461(15): 260-268.
21.Diao J, Feng B, Ying W, Qianqian H, XiXu H, Zhang Q, Yanqing W, Engineering of pectin-dopamine nano-conjugates for carrying ruthenium complex: A potential tool for biomedical applications. J J Inorg Biochem. 2019; 191(4): 135-142.
22.Pan Y, Hua M, Liping H, Juan H, Yan L, Ziwei H, Li J, Yang A, Graphene enhanced transformation of lignin in laccase-ABTS system by accelerating electron transfer. Enzyme Microb Technol. 2018; 119 (3): 17-23.
23.Glisic M, Qiang F, Zhe L, Meng‐Lin L, Shuang‐Qing Z, Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. Maturitas, 2018; 115(25): 74-83.
24.Paschalis E P, Gamsjaeger N, Hassler A, Fahrleitner-P, Dobnig H, Stepan J.J, I.Pavo E, eKlaushofer K,, Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality. Bone. 2017; 95(3): 41-46.
25.Achillas C, Aidonis D, Lakovou E, Thymianidisa M, Tzetzis Da, A methodological framework for the inclusion of modern additive manufacturing into the production portfolio of a focused factory. JMSY. 2015; 37(1): 328-339.
26.Schmidt M,Marion M, David B, Dimitri D, Tino H, Konrad W, Ludger O, Frank V, Gideon N, Laser based additive manufacturing in industry and academia. CIRP Ann Manuf Technol. 2017; 66(2): 561-583.
27.Amed S, Occupational dermatitis in the manufacture of color television tubes. American Am J Contact Dermat. 1997; 8(4): 222-224.
28.Venkatachalam M, Hélène M,Laurent D, Mireille Fac, Production of pigments from the tropical marine-derived fungi Talaromyces albobiverticillius: New resources for natural red-colored metabolites. J Food Compos Anal. 2018; 70(2): 35-48.
29.Steinhauser G, Johannes H, Sterba M, Foster F, Grass M, Heavy metals from pyrotechnics in New Years Eve snow. Atmos Chem Phys. 2008; 42(37): 8616-8622.
30.Pasquet V, Jean-René C, Firas F, Valérie T, Jean-Marie P, Jean B, Bérard R, Kaas B, Serive T, Jean-Paul C, Laurent P, Show M, Study on the microalgal pigments extraction process: Performance of microwave assisted extraction. Process Biochem. 2011; 46(1): 59-67.
31.Xia X, Jiang-ping T,  Yong-jin M, Xiu-li W,  Chang-dong G, Xin-bing Z, Self-supported hydrothermal synthesized hollow Co3O4 nanowire arrays with high supercapacitor capacitance. J Mater Chem A. 2011; 21(25): 9319-9325.
32.Ni Z, Masel R, Rapid production of metal− organic frameworks via microwave-assisted solvothermal synthesis. Comm. 2006; 128(38): 12394-12395.
33.Macwan D, P.N. Dave, Chaturvedi S, A review on nano-TiO2 sol–gel type syntheses and its applications. J Mater Sci. 2011; 46(11): 3669-3686.
34.Li L, Rongyi L, Email Z, Tong Q, Feng M, Facile synthesis of SrCO3 nanostructures in methanol/water solution without additives. Nanoscale Res Lett. 2012; 7(4): 305-315.
35.Zhu, W, Guanglei Z, Jing L,  Qiang Z, Xianglan P,  Shenlin Z, Hierarchical mesoporous SrCO3 submicron spheres derived from reaction-limited aggregation induced “rod-to-dumbbell-to-sphere” self-assembly. CrystEngComm. 2010; 12(6): 1795-1802.
36.Arumugam D,  Mathavan T, Jeshua L, Archana J, Murugan P, Selvaraj S, Umapathy S, Mukul G, Gunadhor S, Michael J, Milton A, Growth Mechanism of Pine-leaf-like Nanostructure from the Backbone of SrCO3 Nanorods using LaMer’s Surface Diffusion: Impact of Higher Surface Energy (γ= 38.9 eV/nm2){111} Plane Stacking Along 110(γ= 3.4 eV/nm2) by First-Principles Calculations. Cryst Growth Des. 2017; 17(2): 6394-6406.
37.Alavi MA, Morsali A, Syntheses and characterization of Sr(OH)2 and SrCO3 nanostructures by ultrasonic method. Ultrason Sonochem. 2010; 17(1):132-138.
38.Yang L, Deqing C, Limin W, Ge G, Huilou S, Facile synthesis of porous flower-like SrCO3 nanostructures by integrating bottom-up and top-down routes. Mater Lett. 2016; 167(15): 4-8.