1Nanotechnology Research Center , School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Targeted Drug Delivery Research Center, School of Pharmauy, Mashhad University of Medical Sciences, Mashhad, Iran
Objective(s):The aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. Materials and Methods:Formulations were produced based on two multilevel 22 full factorial designs. The independent variables were the ratio of drug:time-dependent polymer (X1) and the amount of pectin in formulations (X2). Electrospinning process was used for preparation of nanofibers. The spinning solutions were loaded in 5 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospun nanofibers were collected and evaluated by scanning electron microscopy and drug release in the acid and buffer with pH 6.8 with and without pectinase. Results:Electrospun nanofibers of celecoxib with appropriate morphological properties were produced via electrospinning process. Drug release from electrospun nanofibers was very low in the acidic media; while, drug release in the simulated colonic media was the highest from formulations containing pectin. Conclusion: Formulation F2 (containing drug:ERS with the ratio of 1:2 and 10% pectin) exhibited acceptable morphological characteristics and protection of drug in the upper GI tract and could be a good candidate as a colonic drug delivery system for celecoxib.
 Liu Y, Ma G, Fang D, Xu J, Zhang H, Nie J. Effects of solution properties and electric field on the electrospinning of hyaluronic acid. Carbohyd Polym. 2011; 83(2): 1011-5.
 Shukla RK, Tiwari A. Carbohydrate polymers: Applications and recent advances in delivering drugs to the colon. Carbohyd Polym. 2012; 88(2): 399-416.
 Akhgari A, Abbaspour M, Moradkhanizadeh M. Combination of pectin and eudragit RS and eudragit RL in the matrix of pellets prepared by extrusion-spheronization for possible colonic delivery of 5-amino salicylic acid. Jundishapur J Nat Pharm Prod. 2013; 8(2): 86-92.
 McDonald PF, Lyons JG, Geever LM, Higginbotham CL. In vitro degradation and drug release from polymer blends based on poly(DL-lactide), poly(L-lactideglycolide) and poly(e-caprolactone). J Mater Sci. 2010; 45: 1284-1292.
 Chou SF, Carson D, Woodrow KA. Current strategies for sustaining drug release from electrospun nanofibers. J Control Release. 2015; In Press.
 Rao PR, Diwan PV. Formulation and in vitro evaluation of polymeric films of diltiazem hydrochloride and indomethacin for transdermal administration. Drug Dev Ind Pharm. 1998; 4: 327-333.
 Akhgari A, Farahmand F, Afrasiabi Garekani H, Sadeghi F, Vandamme T. The effect of pectin on swelling and permeability characteristics of free films containing eudragit RL and/or RS as a coating formulation aimed for colonic drug delivery. DARU. 2010; 18(2): 91-96.