1Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
Objective(s): Chitosan, a biodegradable and cationic polysaccharide with increasing applications in biomedicine, possesses many advantages including mucoadhesivity, biocompatibility, and low-immunogenicity. The aim of this study, was investigating the influence of pH, ratio of azelaic acid/chitosan and molecular weight of chitosan on loading efficiency of azelaic acid in chitosan particles. Materials and Methods: A model was generated using artificial neural networks (ANNs) to study interactions between the inputs and their effects on loading of azelaic acid. Results: From the details of the model, pH showed a reverse effect on the loading efficiency. Also, a certain ratio of drug/chitosan (~ 0.7) provided minimum loading efficiency, while molecular weight of chitosan showed no important effect on loading efficiency. Conclusion: In general, pH and drug/chitosan ratio indicated an effect on loading of the drug. pH was the major factor affecting in determining loading efficiency.
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