<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2019</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>6</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effects of combined 5-Fluorouracil and ZnO NPs on human breast cancer MCF-7 Cells: P53 gene expression, Bcl-2 signaling pathway, and invasion activity</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): The signiﬁcant contribution of nanoparticles to cancer treatment has attracted therapeutic attention. The present study aimed to evaluate the synergistic effects of 5-fluorouracil (5-FU) and zinc oxide nanoparticles (ZnO NPs) as multimodal drug delivery on human breast cancer MCF-7 cells.Materials and Methods: In this in-vitro study, the impact of 5-FU and ZnO NPs in the single or combined forms was evaluated on cell viability, colony formation, apoptosis, p53 gene expression, and Bcl-2 signaling protein in MCF-7 breast cancer cell line using several techniques, such as MTT, clonogenic assay, flow cytometry, real-time quantitative polymerase chain reaction, and Western blot.Results: In this study, 5-FU combined with ZnO NPs showed synergistic effects against MCF-7 within 48 hours. In addition, the combination of 5-FU and ZnO NPs at the respective concentrations of 1 µM and 45 µg/ml exhibited significant apoptosis (79.53%), p53 gene expression (3.6 folds), reduction of cell invasion (9.82%), and plating efficiency (5%), thereby leading to the significant reduction of cell viability (40±0.9%) and decreased Bcl-2 anti-apoptotic protein relative to untreated control cells. Conclusion: According to the results, the synergistic effects of combined ZnO NPs and 5-FU on MCF-7 human breast cancer cells were exerted via Bcl-2 inhibition and the up-regulation of p53 expression.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Bcl-2, p53 expression, Zinc oxide naoparticles, 5-fluorouracil</keyword>
				<start_page>232</start_page>
				<end_page>240</end_page>
				<web_url>https://nmj.mums.ac.ir/article_13111.html</web_url>
			<author_list><author>
				<first_name>Safoura</first_name>
				<middle_name></middle_name>
				<last_name>Hoseinzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safoura.hoseinzadeh@gmail.com</email>
				<code>55792</code>
				<coreauthor>No</coreauthor>
				<affiliation>Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Elham</first_name>
				<middle_name></middle_name>
				<last_name>Raeisi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>elham_raeisi@yahoo.com</email>
				<code>55793</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Physics and Radiology, Shahrekord University of Medical Sciences, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yves</first_name>
				<middle_name></middle_name>
				<last_name>Lemoigne</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yv.lemoigne@gmail.com</email>
				<code>55794</code>
				<coreauthor>No</coreauthor>
				<affiliation>Institute for Medical Physics, Ambilly, France</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Esfandiar</first_name>
				<middle_name></middle_name>
				<last_name>Heidarian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>heidarian46@yahoo.com</email>
				<code>55795</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>