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			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
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			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
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			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year></year>
				<month></month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year></year>
				<month></month>
				<day>1</day>
			</pubdate>
			<volume></volume>
			<number></number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Single-Walled carbon nanotubes for precision treatment of Duchenne muscular dystrophy: a mini review</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Duchenne Muscular Dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle degeneration due to mutations in the dystrophin gene. This review aims to critically assess the application of Single-Walled Carbon Nanotubes (SWCNTs) as advanced nanocarriers for DMD treatment. It focuses on overcoming limitations of current strategies—such as poor bioavailability, low targeting efficiency, and off-target toxicity—by leveraging the physicochemical versatility and functionalization potential of SWCNTs.Single-Walled Carbon Nanotubes (SWCNTs) have emerged as a promising nanocarrier system for precision treatment of DMD, offering superior drug-loading capacity, targeted delivery, and enhanced cellular uptake.Their high surface area (~1315 m²/g) and tunable functionalization enable efficient transport of antisense oligonucleotides (ASOs), phosphorodiamidate morpholino oligomers (PMOs), and CRISPR/Cas9 gene-editing complexes to dystrophic muscle fibers. Preclinical studies indicate 70% exon-skipping efficiency and 55% dystrophin restoration with SWCNT-based PMOs, alongside 8-fold higher genome correction efficiency in CRISPR applications. Additionally, SWCNTs exhibit prolonged circulation, improved muscle tissue penetration, and reduced off-target accumulation compared to lipid nanoparticles (LNPs). However, safety concerns such as potential oxidative stress, immune interactions, and long-term biodegradability remain key challenges for clinical translation. Functionalization strategies, AI-driven molecular modeling, and targeted clearance mechanisms are being explored to optimize SWCNT biocompatibility.By addressing current translational barriers—including toxicity, immunogenicity, and large-scale production—SWCNT-based platforms hold substantial promise as next-generation precision therapies for DMD. Their integration into personalized nanomedicine frameworks could redefine treatment paradigms in neuromuscular disorders. Addressing current limitations will be crucial in harnessing SWCNTs as a next-generation precision therapy for DMD, paving the way for personalized nanomedicine applications in neuromuscular disorders.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Duchenne muscular dystrophy, Single-Walled carbon nanotubes, Exon-skipping, Gene Therapy, Drug Delivery, Nanomedicine</keyword>
				<start_page>0</start_page>
				<end_page>0</end_page>
				<web_url>https://nmj.mums.ac.ir/article_26783.html</web_url>
			<author_list><author>
				<first_name>Dilpreet</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dilpreet.daman@gmail.com</email>
				<code>117554</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Raj</first_name>
				<middle_name></middle_name>
				<last_name>Kamal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rajkamal259e@gmail.com</email>
				<code>117565</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>