<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>4</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic effect of Zinc Phthalocyanine (ZnPC)@MIL-101 framework and laser radiation on mcf-7 breast cancer cells: an experimental combination study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Zinc phthalocyanine (ZnPC), a potent photosensitizer for photodynamic therapy (PDT), often suffers from poor solubility and aggregation, limiting its efficacy. Metal-organic frameworks (MOFs) like MIL-101 can serve as nanocarriers to overcome these issues. This experimental study investigates the synthesis, characterization, and synergistic anticancer efficacy of ZnPC incorporated within the MIL-101 framework (ZnPC@MIL-101) against MCF-7 breast cancer cells. ZnPC was chosen for its strong red-light absorption and high reactive oxygen species (ROS) generation, while MIL-101 offers a stable, porous platform to enhance ZnPC delivery and photoactivity.Materials and Methods: ZnPC@MIL-101 (Cr) was synthesized via a double-solvent method. Characterization involved PXRD, BET analysis, FESEM, DLS, EDX spectroscopy, and UV-Vis spectroscopy. The loading capacity was determined, and singlet oxygen generation was quantified. Anticancer efficacy and PDT synergy with 660 nm laser radiation were evaluated on MCF-7 cells using MTT assays. Statistical analysis was performed using ANOVA.Result: Successful synthesis of crystalline ZnPC@MIL-101 was confirmed. The loading capacity of ZnPC was found to be 8.5%. BET analysis showed reduced surface area (1709.4 m²/g) and pore size (1.71 nm) post-ZnPC loading, indicating effective incorporation. FESEM/DLS showed particle sizes around 368/439.7 nm, respectively. EDX confirmed uniform Zn distribution. The UV-Vis spectrum of ZnPC@MIL-101 displayed the characteristic Q-band of ZnPC, and the nanocomposite exhibited significant singlet oxygen generation upon laser irradiation. ZnPC@MIL-101 exhibited moderate dark toxicity (IC50: 25 µg/mL), which was significantly enhanced upon laser irradiation (IC50: 10 µg/mL, p &lt; 0.01).Conclusion: ZnPC@MIL-101 combined with laser radiation demonstrated a significant synergistic reduction in MCF-7 cell viability. This highlights its potential as an effective PDT agent, offering a promising strategy to enhance ZnPC-based cancer treatment.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Metal-organic frameworks, Photosensitizing agents, Drug Delivery, Nanocarrier, Cytotoxicity</keyword>
				<start_page>296</start_page>
				<end_page>309</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27290.html</web_url>
			<author_list><author>
				<first_name>Mahin</first_name>
				<middle_name></middle_name>
				<last_name>Velayati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>velayati_mahin@yahoo.com</email>
				<code>119822</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Sabouri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahra_sabouri68@yahoo.com</email>
				<code>119823</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ramin</first_name>
				<middle_name></middle_name>
				<last_name>Rezaee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rezaeera@mums.ac.ir</email>
				<code>119824</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Hasan</first_name>
				<middle_name></middle_name>
				<last_name>Soheilifar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>h.soheilifar@edu.umsha.ac.ir</email>
				<code>119825</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hoda</first_name>
				<middle_name></middle_name>
				<last_name>Keshmiri Neghab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hodakeshmiri@ut.ac.ir</email>
				<code>119826</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hashemi Ghoochani</first_name>
				<middle_name></middle_name>
				<last_name>Samaneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>samaneh_hq@yahoo.com</email>
				<code>119827</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Hashemzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hashemzadeha971@mums.ac.ir</email>
				<code>119828</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Darroudi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>darroudim@mums.ac.ir</email>
				<code>119829</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>