<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hyaluronic acid-modified PLGA nanoparticles encapsulating METTL14 siRNA enhance sunitinib sensitivity in drug-resistant renal cell carcinoma</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Sunitinib resistance remains a major obstacle in the treatment of renal cell carcinoma (RCC). This study sought to construct a targeted nanoparticle-based delivery system for silencing methyltransferase-like 14 (METTL14), with the aim of restoring drug responsiveness in resistant RCC.Methods: Hyaluronic acid-functionalized poly (lactic-co-glycolic acid) nanoparticles (HA-PLGA-NPs) were engineered to encapsulate METTL14 siRNA. Their physicochemical characteristics, targeting capability toward CD44-positive sunitinib-resistant RCC cells (786-O-SUR and ACHN-SUR), and therapeutic performance were systematically evaluated in vitro. Transcriptomic analysis was conducted to investigate underlying mechanisms. Antitumor efficacy and biosafety were further examined in a xenograft mouse model.Results: The fabricated nanoparticles displayed uniform morphology, appropriate particle size, and high siRNA encapsulation efficiency (&gt;88%), along with favorable stability. HA modification significantly improved cellular uptake in CD44-positive resistant cells compared with non-targeted nanoparticles. Delivery of METTL14 siRNA via HA-PLGA-NPs markedly reduced the IC50 of sunitinib, increased apoptotic cell death, and effectively reversed drug resistance. In vivo, treatment with HA-PLGA (METTL14 siRNA)-NPs led to substantial tumor growth inhibition. RNA sequencing indicated that METTL14 silencing was associated with pathways involved in apoptosis, cell cycle regulation, and immune-related processes. No obvious systemic toxicity was observed.Conclusion: HA-PLGA nanoparticles provide an effective and selective platform for METTL14 siRNA delivery, enabling reversal of sunitinib resistance in RCC models. This approach offers a potential therapeutic strategy for overcoming drug resistance in renal cell carcinoma.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Renal cell carcinoma, Drug resistance, Nanoparticles, RNA, Small Interfering, Methyltransferases</keyword>
				<start_page>430</start_page>
				<end_page>441</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27772.html</web_url>
			<author_list><author>
				<first_name>Yue</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gaoyue0549@163.com</email>
				<code>122092</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xuelian</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1025618604@qq.com</email>
				<code>122094</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lei</first_name>
				<middle_name></middle_name>
				<last_name>Cui</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18895304947@163.com</email>
				<code>122093</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pengcheng</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>122102</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fang</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>398370868@qq.com</email>
				<code>122095</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Baobao</first_name>
				<middle_name></middle_name>
				<last_name>Fu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18755453135@163.com</email>
				<code>122096</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chenchen</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>191219489@qq.com</email>
				<code>122097</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qianqian</first_name>
				<middle_name></middle_name>
				<last_name>Jia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>978108646@qq.com</email>
				<code>122098</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hongjiang</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1076884339@qq.com</email>
				<code>122099</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jin</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18255450971@163.com</email>
				<code>122100</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yong</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wangyong2095@163.com</email>
				<code>122101</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>