<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>4</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Transfersomes-based nanocarriers for anticancer drug delivery: a promising approach</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Chemotherapy is typically used to treat cancer, but it can have a number of negative side effects. Nanocarrier-based drug delivery systems have gained much interest cancer treatment in recent years due to their advantages compared to conventional delivery systems. Recently, transfersomes (TFs) have been known to be the most outstanding innovative drug delivery systems that make them an attractive carriers for drug administration and cancer therapy. TFs have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic drugs/agents with higher permeation efficiencies, offering a promising alternative to conventional liposomes as an anti-cancer drug delivery method. They are highly interesting for applications that involve controlled release. TFs are being explored as a complex system for drug delivery, with a focus on enhancing local drug penetration. This paper overview the current advancements in transfersomes-encapsulated with anti-cancer drugs for intelligent medication delivery to various cancers. In conclusion, this paper briefly discusses the prospects and problems of transfersomes-based anti-cancer drug delivery.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Nanocarriers, Transfersomes, Drug Delivery, Cancer, Liposomes</keyword>
				<start_page>238</start_page>
				<end_page>255</end_page>
				<web_url>https://nmj.mums.ac.ir/article_26739.html</web_url>
			<author_list><author>
				<first_name>Farnoush</first_name>
				<middle_name></middle_name>
				<last_name>Mohamadpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farnoosh.mohammadpour@yahoo.com</email>
				<code>117366</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Chakeri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zchakeri@uw.edu</email>
				<code>117367</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cardiothoracic Imaging Section, Department of Radiology, University of Washington, Seattle, WA, USA</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mojgan</first_name>
				<middle_name></middle_name>
				<last_name>Sheikhi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sheikhi_mojgan@yahoo.com</email>
				<code>117368</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saghi</first_name>
				<middle_name></middle_name>
				<last_name>Naderpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saaghinaderpour@gmail.com</email>
				<code>117369</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Pharmacy, Eastern Mediterranean University Famagusta, North Cyprus via Mersin 10, Turkey.|Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Milad</first_name>
				<middle_name></middle_name>
				<last_name>Rahimzadegan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>milad.rahimzadegan@gmail.com</email>
				<code>117370</code>
				<coreauthor>No</coreauthor>
				<affiliation>Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Sharafshah</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alirezasharafshah@yahoo.com</email>
				<code>117371</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farshid</first_name>
				<middle_name></middle_name>
				<last_name>Sefat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>f.sefat1@bradford.ac.uk</email>
				<code>117372</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Bio-medical Engineering, School of Engineering, University of Bradford, Bradford, UK|Interdisciplinary Research Center in Polymer Science &amp; Technology (Polymer IRC), University of Bradford, Bradford, UK</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rahim</first_name>
				<middle_name></middle_name>
				<last_name>Nosrati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nosratirahim@gmail.com</email>
				<code>117373</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran|Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Quantum dot-based sensors and nanotheranostics for early detection and targeted therapy for colorectal cancer</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Introduction: Colorectal cancer (CRC) remains one of the most prevalent and fatal cancers worldwide, highlighting the urgent need for the development of advanced diagnostic and therapeutic strategies.Objective(s): Quantum dots (QDs), semiconductor nanomaterials with distinctive optical properties, have emerged as promising tools in the fight against colorectal cancer (CRC).Materials and Methods: The ability of QDs to emit tunable fluorescence, combined with their small size and potential for surface functionalization, enables high sensitivity and specificity in early detection and targeted treatment. In the context of CRC, QDs can be used to identify biomarkers such as carcinoembryonic antigen (CEA) and folate receptors, facilitating non-invasive imaging with high resolution.Results: Furthermore, QDs can be functionalized for targeted therapy, enhancing the selective delivery of chemotherapeutic agents to tumor sites, reducing systemic toxicity, and allowing real-time monitoring of treatment efficacy. Despite these advantages, the clinical application of QDs in CRC is limited by challenges, including toxicity, biocompatibility, long-term stability, and efficient targeting. This review examines the current state of quantum dot-based technologies in CRC diagnostics and therapy, emphasizing their potential as nanotheranostic platforms. We also address the key barriers to clinical translation and propose future research directions to improve quantum dots&#039; safety, efficiency, and clinical utility in CRC management.Conclusion: Ultimately, quantum dots offer significant potential to revolutionize the diagnosis and treatment of colorectal cancer, paving the way for more personalized and effective patient care.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Colorectal Neoplasms, Quantum dots, Nanoparticles, Nanotheranostics, Targeted therapy, Early detection</keyword>
				<start_page>256</start_page>
				<end_page>267</end_page>
				<web_url>https://nmj.mums.ac.ir/article_26132.html</web_url>
			<author_list><author>
				<first_name>Dilpreet</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dilpreet.daman@gmail.com</email>
				<code>114721</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Raj</first_name>
				<middle_name></middle_name>
				<last_name>Kamal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rajkamal259e@gmail.com</email>
				<code>114722</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Influence of cell penetrating peptides on efficiency of lipid nanoparticles containing chemotherapeutics</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Cell-penetrating peptides (CPPs) are a group of short peptides that easily pass through the cell membrane and are able to carry various types of cargoes, such as drugs, nucleic acids, and proteins, into cells. Therefore, CPPs are investigated with the aim of effective drug delivery to treat diseases such as cancer, diabetes and genetic disorders. CPPs have different applications in different fields.CPPs have common functions and some structural features, such as a high content of positively charged amino acids, but their structural differences are in the high variety of elements in them. In this paper, the effect of cell penetrating peptides on the efficiency of lipid nanoparticles containing chemotherapeutics is reviewed. Various drug delivery systems such as liposomes, solid lipid nanoparticles and exosomes were considered. Both in-vitro and in-vivo delivery routes were discussed.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cell-penetrating peptides, Drug Delivery, Lipid nanoparticles, Cancer</keyword>
				<start_page>268</start_page>
				<end_page>282</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27088.html</web_url>
			<author_list><author>
				<first_name>Behrad</first_name>
				<middle_name></middle_name>
				<last_name>Khoshbin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khoshbinb982@mums.ac.ir</email>
				<code>118934</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Khalili Azimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>az.khalili5@gmail.com</email>
				<code>118935</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemical Engineering, School of Biotechnology, Malek Ashtar University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahmoud Reza</first_name>
				<middle_name></middle_name>
				<last_name>Jaafari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jafarimr@mums.ac.ir</email>
				<code>118936</code>
				<coreauthor>No</coreauthor>
				<affiliation>Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bizhan</first_name>
				<middle_name></middle_name>
				<last_name>Malaekeh-Nikouei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>malaekehb@mums.ac.ir</email>
				<code>118933</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Harnessing liposome technology for precision medicine: design, delivery, and clinical impact</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Liposomes are microspheres formed by phospholipids and have received attention as sophisticated drug carriers because they can retain both water-soluble and fat-soluble drugs. Their applications have made them very versatile and have resulted in their great exploration in many aspects of therapy.Objective(s):The present review sets out to provide an exhaustive overview of the nature of liposomes, their preparation tactics, measures of their efficiency, and the trending applications of liposomes in contemporary medicine, with a focus on optimization measures and the future of this technology.Materials and Methods: The mini-review of the literature was done with an emphasis on the various methods of liposome preparation, which included the Bangham method, solvent injection methods, as well as the removal methods of detergents. Efficiency was analyzed based on optimization and evaluation parameters, including vesicle size, shape, zeta potential, and in vitro release profile of the drug to evaluate their contribution to formulation efficiency.Results: Recent innovations have resulted in the creation of new generation liposomal systems, such as active targeting liposomes, stimuli-reactive liposomes, and surface-modified liposomes. These advances bring substantive benefits to drug delivery effectiveness and outcomes in the therapeutic arena and decreased systemic toxicities. Liposomal formulations find increasing use in cancer treatment, in the treatment of infectious diseases, and in gene delivery. A number of novel systems are in the clinical trial stage, indicating their translational potential.Conclusion: Liposomes are a very flexible and evolving drug delivery mechanism. The development of improved surface modification, targeting approaches, and stimuli-responsive systems still augers well with the therapeutic potential. Continuing advances in the development and clinical assessment of new liposomal preparations demonstrate the future of these agent-carrying constructs to transform the field of disease management in the domains of cancer, infectious disease, and gene therapy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Antineoplastic agents, Drug delivery systems, Gene Therapy, Liposomes, Nanomedicine</keyword>
				<start_page>283</start_page>
				<end_page>295</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27013.html</web_url>
			<author_list><author>
				<first_name>Ganugapenta</first_name>
				<middle_name></middle_name>
				<last_name>Nikhil Kumar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nikhilkumar60056@gmail.com</email>
				<code>118583</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Edukulla</first_name>
				<middle_name></middle_name>
				<last_name>Satheesh Kumar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>satheeshmpharma@gmail.com</email>
				<code>118586</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Thirumalesh</first_name>
				<middle_name>Naik Sugali</middle_name>
				<last_name>Banoth</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>naik.thirumalesh@gmail.com</email>
				<code>118587</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Archana</first_name>
				<middle_name></middle_name>
				<last_name>Sugunarajan Latha</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>archanasugunarajan42@gmail.com</email>
				<code>118584</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bhargavi</first_name>
				<middle_name></middle_name>
				<last_name>Melehalli Shivaraju</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>msbhargavigowda11@gmail.com</email>
				<code>118585</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hindustan</first_name>
				<middle_name></middle_name>
				<last_name>Abdul Ahad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abdulhindustan@gmail.com</email>
				<code>118582</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of R R College of Pharmacy, Chikkabanavara, Bengaluru, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic effect of Zinc Phthalocyanine (ZnPC)@MIL-101 framework and laser radiation on mcf-7 breast cancer cells: an experimental combination study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Zinc phthalocyanine (ZnPC), a potent photosensitizer for photodynamic therapy (PDT), often suffers from poor solubility and aggregation, limiting its efficacy. Metal-organic frameworks (MOFs) like MIL-101 can serve as nanocarriers to overcome these issues. This experimental study investigates the synthesis, characterization, and synergistic anticancer efficacy of ZnPC incorporated within the MIL-101 framework (ZnPC@MIL-101) against MCF-7 breast cancer cells. ZnPC was chosen for its strong red-light absorption and high reactive oxygen species (ROS) generation, while MIL-101 offers a stable, porous platform to enhance ZnPC delivery and photoactivity.Materials and Methods: ZnPC@MIL-101 (Cr) was synthesized via a double-solvent method. Characterization involved PXRD, BET analysis, FESEM, DLS, EDX spectroscopy, and UV-Vis spectroscopy. The loading capacity was determined, and singlet oxygen generation was quantified. Anticancer efficacy and PDT synergy with 660 nm laser radiation were evaluated on MCF-7 cells using MTT assays. Statistical analysis was performed using ANOVA.Result: Successful synthesis of crystalline ZnPC@MIL-101 was confirmed. The loading capacity of ZnPC was found to be 8.5%. BET analysis showed reduced surface area (1709.4 m²/g) and pore size (1.71 nm) post-ZnPC loading, indicating effective incorporation. FESEM/DLS showed particle sizes around 368/439.7 nm, respectively. EDX confirmed uniform Zn distribution. The UV-Vis spectrum of ZnPC@MIL-101 displayed the characteristic Q-band of ZnPC, and the nanocomposite exhibited significant singlet oxygen generation upon laser irradiation. ZnPC@MIL-101 exhibited moderate dark toxicity (IC50: 25 µg/mL), which was significantly enhanced upon laser irradiation (IC50: 10 µg/mL, p &lt; 0.01).Conclusion: ZnPC@MIL-101 combined with laser radiation demonstrated a significant synergistic reduction in MCF-7 cell viability. This highlights its potential as an effective PDT agent, offering a promising strategy to enhance ZnPC-based cancer treatment.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Metal-organic frameworks, Photosensitizing agents, Drug Delivery, Nanocarrier, Cytotoxicity</keyword>
				<start_page>296</start_page>
				<end_page>309</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27290.html</web_url>
			<author_list><author>
				<first_name>Mahin</first_name>
				<middle_name></middle_name>
				<last_name>Velayati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>velayati_mahin@yahoo.com</email>
				<code>119822</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Sabouri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahra_sabouri68@yahoo.com</email>
				<code>119823</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ramin</first_name>
				<middle_name></middle_name>
				<last_name>Rezaee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rezaeera@mums.ac.ir</email>
				<code>119824</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Hasan</first_name>
				<middle_name></middle_name>
				<last_name>Soheilifar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>h.soheilifar@edu.umsha.ac.ir</email>
				<code>119825</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hoda</first_name>
				<middle_name></middle_name>
				<last_name>Keshmiri Neghab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hodakeshmiri@ut.ac.ir</email>
				<code>119826</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hashemi Ghoochani</first_name>
				<middle_name></middle_name>
				<last_name>Samaneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>samaneh_hq@yahoo.com</email>
				<code>119827</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Hashemzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hashemzadeha971@mums.ac.ir</email>
				<code>119828</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Darroudi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>darroudim@mums.ac.ir</email>
				<code>119829</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>L-Carnosine-coated nanoceria promotes proliferation of human embryonic lung fibroblasts via STAT3/BCL2 axis activation</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Nanoceria exhibits unique catalytic activity toward reactive oxygen species (ROS), mimicking the functions of natural enzymes—a property that underlies its biomedical applications, given the essential role of ROS in living organisms. Carnosine is a pH buffer with intrinsic antioxidant properties; it chelates metals and binds carbonyl compounds.Objective(s): Using human embryonic lung fibroblast model, this study investigates the impacts of carnosine-conjugated nanoscale CeO2 on cell survival, cellular oxidative status, ROS-induced DNA oxidation, dual-strand DNA breaks, activation of DNA repair response, and gene and protein expression of NOX4, NRF2, STAT3, as well as proliferation and autophagy markers.Results: Carnosine-conjugated nanoceria proved to be non-cytotoxic at millimolar concentrations. Its effects on cytotoxicity, genotoxicity, DNA repair, mitochondrial membrane potential, autophagy, and NOX4 and NRF2 expression were similar to those of bare nanoceria. The principal differences were observed in the expression of STAT3, PCNA, and BCL2 proteins, where carnosine‑coated nanoceria induced a pronounced activating impact after 24 h of exposure, thus promoting proliferation and increasing concentration of the PCNA proliferation marker.Conclusion: We hypothesize that carnosine‑coated nanoceria directly activates the STAT3/BCL2 axis. These findings may facilitate the development of new molecular models for studying signaling pathways and advance in characterization of the nanoceria’s biochemical roles in regulating ROS‑driven cellular pathways. Moreover, carnosine‑coated nanoceria could be considered a potential agent for enhancing the survival of cell cultures—such as hematopoietic cultures intended for transplantation—through activation of the STAT3/BCL2 axis.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Ceric oxide, carnosine, Cell Proliferation, Reactive Oxygen Species, Fibroblasts</keyword>
				<start_page>310</start_page>
				<end_page>326</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27301.html</web_url>
			<author_list><author>
				<first_name>Elena</first_name>
				<middle_name>V</middle_name>
				<last_name>Proskurnina</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>proskurnina@gmail.com</email>
				<code>119884</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia|Faculty of Chemistry, Biology and Biotechnology, North Ossetian State University named after Kosta Levanovich Khetagurov, Vladikavkaz, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Madina</first_name>
				<middle_name>M.</middle_name>
				<last_name>Sozarukova</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>s_madinam@bk.ru</email>
				<code>119885</code>
				<coreauthor>No</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Elizaveta</first_name>
				<middle_name>S.</middle_name>
				<last_name>Ershova</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>es-ershova@rambler.ru</email>
				<code>119886</code>
				<coreauthor>No</coreauthor>
				<affiliation>Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Natalia</first_name>
				<middle_name>N</middle_name>
				<last_name>Veiko</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>satelit32006@yandex.ru</email>
				<code>119887</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Matvei</first_name>
				<middle_name>A</middle_name>
				<last_name>Popkov</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ma_popkov@igic.ras.ru</email>
				<code>119888</code>
				<coreauthor>No</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Edmund</first_name>
				<middle_name>V</middle_name>
				<last_name>Kostyuk</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>edmundvk@ya.ru</email>
				<code>119889</code>
				<coreauthor>No</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vladimir</first_name>
				<middle_name>K</middle_name>
				<last_name>Ivanov</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>van@igis.ras.ru</email>
				<code>119890</code>
				<coreauthor>No</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Svetlana</first_name>
				<middle_name>V</middle_name>
				<last_name>Kostyuk</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>svet-vk@yandex.ru</email>
				<code>119891</code>
				<coreauthor>No</coreauthor>
				<affiliation>Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia|Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Russian Scientific Center of Surgery named after Academician B.V. Petrovsky, Moscow, Russia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Curcumin/Ag conjugated nanoparticles confer neuroprotection against hyoscine-induced acute psychosis: behavioral and biochemical evidence</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Obejctive(s): Psychosis is a prevalent psychiatric disorder. Chemicals that modulate the dopaminergic system have been the primary treatment, but these drugs have not always been effective, and some have deleterious side effects. During the last several years, a concerted effort has been made to advance the development of novel pharmaceuticals, utilizing approaches such as nanotechnology, natural compounds, and Eastern medicinal practices. Nanotechnology, including Ag-based nanoparticles, is an exciting option for optimizing drug performance, including reduced side effects and improved pharmacological and clinical profiles. The impact of curcumin‐Ag conjugated nanoparticles (Cur/Ag NPs)  was evaluated in a rodent model of psychosis.Materials and Methods: Cur/Ag NPs were synthesized and characterized by FTIR, FE-SEM, EDX, and UV-vis spectrophotometry. The effect of Cur-Ag NPs was determined for several psychosis-related behaviors (Yawning number, rearing number, and stereotype score) and blood levels of the inflammatory factors CRP, TNF-α, and IL-1β, and cortisol in an animal model of hyoscine-induced psychosis.Results: Cur/Ag NPs modulated the Yawning number, rearing number, and stereotypic score in hyoscine-induced acute psychosis and attenuated the blood levels of inflammatory parameters, including TNF-α, IL-1β, C-reactive protein, and cortisol. Cur/Ag NPs demonstrated greater efficacy compared to curcumin, altering these effects at lower concentrations.Conclusion: Cur/Ag NPs and Curcumin were effective in a mouse model of psychosis, exhibiting protective effects against hyoscine-induced acute psychosis, and may be potential candidates for further clinical investigation for treating psychosis-related behavior.    ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Psychosis, Curcumin/Ag conjugated nanoparticles, Curcumin</keyword>
				<start_page>327</start_page>
				<end_page>343</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27355.html</web_url>
			<author_list><author>
				<first_name>Setayesh</first_name>
				<middle_name></middle_name>
				<last_name>Abdolkarimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abdolkarimisetayesh148@gmail.com</email>
				<code>120134</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahsa</first_name>
				<middle_name></middle_name>
				<last_name>Salehirad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahsa91rad@gmail.com</email>
				<code>120135</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>A. Wallace</first_name>
				<middle_name></middle_name>
				<last_name>Hayes</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>awallacehayess@gmail.com</email>
				<code>120136</code>
				<coreauthor>No</coreauthor>
				<affiliation>University of South Florida College of Public Health, Tampa, FL, USA and Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Motaghinejad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.motaghinejad6@gmail.com</email>
				<code>120137</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Pediatric Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Malak</first_name>
				<middle_name></middle_name>
				<last_name>Hekmati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mhekmatik@yahoo.com</email>
				<code>120138</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Monte Carlo simulation of Au@MNP nanoparticles for MRI-guided proton therapy: tailoring core-shell architecture for dose enhancement</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Integrating magnetic resonance imaging (MRI) with proton therapy holds significant promise for enhancing treatment efficacy. Magnetic nanoparticles (MNPs), such as gadolinium and superparamagnetic iron oxide nanoparticles (SPIONs), are well-known for improving tissue contrast in MRI. In this study, we investigate the potential of core–shell nanoparticles (Au@MNPs) as agents that can enhance the delivery of therapeutic doses to targeted tissues. Specifically, we examine how variations in core diameter and shell thickness, using either gadolinium oxide (Gd₂O₃) or SPION shells, influence dose enhancement.Materials and Methods: A simulated proton beam with a weighted energy spectrum—representing both primary and secondary protons within the Spread-Out Bragg Peak (SOBP) region—was used to irradiate the nanoparticles. The energy deposited within the nanoparticles, as well as the phase space of surrounding secondary particles, was evaluated. Key parameters, including energy efficiency, total energy release, and the number of secondary electrons, were analyzed to compare the performance of various nanoparticle designs.Results: Our findings indicate that incorporating a gold core is advantageous for thin magnetic layers (&lt;15 nm), as it enhances the dose around the nanoparticle while maintaining a size compatible with MRI applications (&lt;20 nm). In contrast, for thicker magnetic layers (greater than 20 nm), a larger gold core diameter is required to achieve effective dose enhancement.Conclusion: These results suggest that embedding a gold core with a diameter of less than 15 nm within MRI-compatible nanoparticles is a promising strategy for enhancing dose delivery in proton therapy. Further studies are warranted to investigate the impact of core–shell nanoparticles on magnetic properties, which are critical for their theranostic potential.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Theranostic nanomedicine, Radiosensitizing agents, Proton Therapy, magnetic resonance imaging, Metal Nanoparticles, Monte Carlo Method</keyword>
				<start_page>344</start_page>
				<end_page>355</end_page>
				<web_url>https://nmj.mums.ac.ir/article_26742.html</web_url>
			<author_list><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Bordbar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bordbar7495@gmail.com</email>
				<code>117383</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammadreza</first_name>
				<middle_name></middle_name>
				<last_name>Parishan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>parishanmohammadreza@yahoo.com</email>
				<code>117384</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rasool</first_name>
				<middle_name></middle_name>
				<last_name>Safari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>r.safariphysic@gmail.com</email>
				<code>117385</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Rakeb</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rakeb.zahra@gmail.com</email>
				<code>117386</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Comparative evaluation of cytotoxicity and inflammatory responses induced by free and eugenol-loaded titanium dioxide nanoparticles following intraperitoneal injection in mouse</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Titanium dioxide nanoparticles (TiO₂ NPs), which are widely used in food and consumer products, have been associated with oxidative stress and inflammatory toxicity. Eugenol, a naturally occurring phenolic compound with well-established anti-inflammatory and antioxidant properties, may exert protective effects when delivered through nanocarriers.Materials and Methods: TiO₂ nanoparticles were synthesized via a co-precipitation method and subsequently functionalized with eugenol (TiO₂@eugenol). FTIR, XRD, DLS, zeta potential analysis, FE-SEM, and TEM were used to characterize the nanoparticles. Thirty-six BALB/cJ mice were randomly assigned to six groups (n = 6 per group). They received intraperitoneal injections of free eugenol, TiO₂ nanoparticles, or TiO₂@eugenol at low (50 mg/kg) or high (200 mg/kg) doses for 14 days. Following the treatment period, serum concentrations of IL-1β, IL-6, and TNF-α were measured using ELISA; hepatic caspase-3/7 activity was assessed; and histological examinations of the liver, kidney, and spleen were performed. Gene expression of antioxidant markers (SOD3, GR, GPx) in liver tissue was evaluated by qRT-PCR.Results: TiO₂ NPs significantly increased pro-inflammatory cytokines and hepatic caspase-3/7 activity. They also induced necrosis and inflammatory alterations in the liver, kidney, and spleen. In contrast, TiO₂@eugenol markedly suppressed cytokine release and apoptotic activity while preserving tissue architecture. qRT-PCR analysis showed that TiO₂ NPs downregulated antioxidant-related genes, whereas TiO₂@eugenol significantly upregulated their expression, indicating improved redox homeostasis.Conclusion: Eugenol functionalization improved the biocompatibility profile of TiO₂ NPs and provided substantial protection against TiO₂-induced toxicity by attenuating inflammation, apoptosis, and oxidative stress while restoring antioxidant defenses. These findings highlight the therapeutic potential of eugenol-loaded TiO₂ nanoparticles and support further investigation in extended exposure models and disease-specific applications.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Titanium dioxide, NPs, Eugenol, Inflammation, Cytotoxicity</keyword>
				<start_page>356</start_page>
				<end_page>370</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27218.html</web_url>
			<author_list><author>
				<first_name>Farazdaq Nazar</first_name>
				<middle_name></middle_name>
				<last_name>Al-Naffakh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farazdaqalnafakh@gmail.com</email>
				<code>119523</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Somayeh</first_name>
				<middle_name></middle_name>
				<last_name>Reiisi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>s.reiisi@yahoo.com</email>
				<code>119524</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Norolhoda</first_name>
				<middle_name></middle_name>
				<last_name>Khalighi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>norolhoda.khalighi@yahoo.com</email>
				<code>119525</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Elham</first_name>
				<middle_name></middle_name>
				<last_name>Moghtadaei Khorasgani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>moghtadaei_e@yahoo.com</email>
				<code>119526</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathobiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>