<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Single-Walled carbon nanotubes for precision treatment of Duchenne muscular dystrophy: a mini review</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Duchenne Muscular Dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle degeneration due to mutations in the dystrophin gene. This review aims to critically assess the application of Single-Walled Carbon Nanotubes (SWCNTs) as advanced nanocarriers for DMD treatment. It focuses on overcoming limitations of current strategies—such as poor bioavailability, low targeting efficiency, and off-target toxicity—by leveraging the physicochemical versatility and functionalization potential of SWCNTs.Single-Walled Carbon Nanotubes (SWCNTs) have emerged as a promising nanocarrier system for precision treatment of DMD, offering superior drug-loading capacity, targeted delivery, and enhanced cellular uptake.Their high surface area (~1315 m²/g) and tunable functionalization enable efficient transport of antisense oligonucleotides (ASOs), phosphorodiamidate morpholino oligomers (PMOs), and CRISPR/Cas9 gene-editing complexes to dystrophic muscle fibers. Preclinical studies indicate 70% exon-skipping efficiency and 55% dystrophin restoration with SWCNT-based PMOs, alongside 8-fold higher genome correction efficiency in CRISPR applications. Additionally, SWCNTs exhibit prolonged circulation, improved muscle tissue penetration, and reduced off-target accumulation compared to lipid nanoparticles (LNPs). However, safety concerns such as potential oxidative stress, immune interactions, and long-term biodegradability remain key challenges for clinical translation. Functionalization strategies, AI-driven molecular modeling, and targeted clearance mechanisms are being explored to optimize SWCNT biocompatibility.By addressing current translational barriers—including toxicity, immunogenicity, and large-scale production—SWCNT-based platforms hold substantial promise as next-generation precision therapies for DMD. Their integration into personalized nanomedicine frameworks could redefine treatment paradigms in neuromuscular disorders. Addressing current limitations will be crucial in harnessing SWCNTs as a next-generation precision therapy for DMD, paving the way for personalized nanomedicine applications in neuromuscular disorders.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Duchenne muscular dystrophy, Single-Walled carbon nanotubes, Exon-skipping, Gene Therapy, Drug Delivery, Nanomedicine</keyword>
				<start_page>371</start_page>
				<end_page>380</end_page>
				<web_url>https://nmj.mums.ac.ir/article_26783.html</web_url>
			<author_list><author>
				<first_name>Dilpreet</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dilpreet.daman@gmail.com</email>
				<code>117554</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Raj</first_name>
				<middle_name></middle_name>
				<last_name>Kamal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rajkamal259e@gmail.com</email>
				<code>117565</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Advances in nanocarriers for Zingiber officinale phytochemicals: enhancing bioavailability and therapeutic potential</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Zingiber officinale, commonly known as ginger, is a medicinal plant esteemed for its diverse pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. The primary bioactive compounds found in ginger, particularly gingerol and shogaol, have shown notable therapeutic benefits but are limited by poor solubility, instability, and low bioavailability. Recent advancements in nanotechnology have introduced innovative delivery systems that address these limitations by enhancing stability, improving bioavailability, and facilitating targeted delivery of these bioactive compounds. Notable nanocarrier systems include polymeric nanoparticles, micelles, nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and metal-based nanoparticles. Research indicates that polymeric and chitosan-based systems significantly enhance the oral absorption, antibacterial efficacy, and DNA-protective properties of ginger constituents. Micellar carriers, specifically, have demonstrated increased oral bioavailability and hepatoprotective benefits of 6-shogaol. Lipid-based nanoparticles have also made notable advances, offering sustained release, enhanced tissue penetration, and high entrapment efficiency for both topical and oral applications. Additionally, green-synthesized metal nanoparticles, including silver, zinc oxide, and iron oxide, have exhibited potent antioxidant, antimicrobial, and anti-inflammatory activities, further establishing their role in expanding the therapeutic potential of ginger. Despite these promising developments, further research is imperative to optimize formulations, assess long-term safety, and determine the feasibility of large-scale clinical application. The integration of nanotechnology into ginger-based therapies holds significant promise for overcoming the limitations associated with traditional formulations and enhancing their therapeutic efficacy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Zingiber officinale, Gingerol, Nanoparticles, Bioavailability, Nanocarriers</keyword>
				<start_page>381</start_page>
				<end_page>396</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27665.html</web_url>
			<author_list><author>
				<first_name>Reynelda</first_name>
				<middle_name>Juliani</middle_name>
				<last_name>Sagala</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>reynelda57@gmail.com</email>
				<code>121507</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Melva</first_name>
				<middle_name></middle_name>
				<last_name>Louisa</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>melva.louisa@gmail.com</email>
				<code>121508</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine Universitas Indonesia, Central Jakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Raditya</first_name>
				<middle_name></middle_name>
				<last_name>Iswandana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>raditya@farmasi.ui.ac.id</email>
				<code>121509</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Silvia</first_name>
				<middle_name></middle_name>
				<last_name>Surini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>silvia@farmasi.ui.ac.id</email>
				<code>121506</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Chitosan-based nanocomposites and nanomaterials for drug delivery of antimicrobial agents: a review</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[With the indiscriminate use of antibiotics and increasing environmental issues, microbial resistance has emerged as a serious and growing global challenge. Moreover, the discovery and development of new antimicrobial agents remain difficult, expensive, and time-consuming. Therefore, the use of advanced drug delivery systems that enhance drug efficacy while reducing side effects has been proposed as a promising alternative strategy. To collect relevant literature, databases such as PubMed and Scopus, as well as search engines such as Google Scholar, were used. Nanomaterials—including nanocomposites, nanoparticles, nanoclays, and nanofibers—play a critical role in these delivery systems. Among them, chitosan, a non-toxic natural polymer with inherent antimicrobial properties, is fundamental because it can overcome many of the limitations of conventional delivery systems. Combining antimicrobial compounds with chitosan not only facilitates effective drug delivery but can also produce synergistic effects, thereby enhancing antimicrobial activity, improving bioavailability, prolonging release, and reducing microbial resistance. The structural characteristics of chitosan, such as its mucoadhesive properties, enable strong binding to biological tissues, which can be further modified for targeted delivery of antimicrobial agents. Chitosan-based nanocomposites also exhibit a high loading capacity for antibacterial agents, owing to their porous architecture, large surface area, and abundant functional groups that facilitate efficient drug binding. Recent advances emphasize the potential of these materials in treating bacterial infections, particularly in wound dressings, biomedical implants, and mucosal drug delivery systems. This review highlights various antimicrobial agents that can be incorporated into chitosan-based nanomaterials, including antibiotics, antifungals, metallic nanoparticles, antivirals, and other bioactive compounds such as toxins and natural products.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Antimicrobial, Chitosan, Drug Delivery, Nanocomposites, Nanomaterials</keyword>
				<start_page>397</start_page>
				<end_page>416</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27141.html</web_url>
			<author_list><author>
				<first_name>Yegane</first_name>
				<middle_name></middle_name>
				<last_name>Hosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yegiiu1379@gmail.com</email>
				<code>119198</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jebraeil</first_name>
				<middle_name></middle_name>
				<last_name>Movaffagh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>movaffaghj@mums.ac.ir</email>
				<code>119199</code>
				<coreauthor>No</coreauthor>
				<affiliation>Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vahid</first_name>
				<middle_name></middle_name>
				<last_name>Soheili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>soheiliv@mums.ac.ir</email>
				<code>119200</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reza</first_name>
				<middle_name></middle_name>
				<last_name>Mostafazade</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mostafazade.r77@gmail.com</email>
				<code>119201</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bibi Sedigheh</first_name>
				<middle_name></middle_name>
				<last_name>Fazly Bazzaz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fazlis@mums.ac.ir</email>
				<code>119202</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Development of a rapid and sensitive electrochemical sensing assay by applying metal-organic framework/multi-walled carbon nanotubes (MOF/MWCNTs) for determination of ascorbic acid</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objectives: L-ascorbic acid (AA, vitamin C), has important bodily functions, including immune defense, collagen formation, and metabolism. Symptoms of many diseases like cancer or cardiovascular disorders can be observed owing to maladjustment or deficiency. Hence, developing sensitive and rapid methods to determine AA in biological samples is essential. In this study, a novel electrochemical sensing assay based on Zn metal-organic framework embedded in multi-walled carbon nanotubes (Zn-MOF/MWCNTs) has been effectively developed to modify glassy carbon electrode (GCE).Materials and Methods: Zn-MOF was synthesized using the solvothermal technique and mixed with multi-walled carbon nanotubes to obtain a modifier suspension. Various characterization methods including XRD (X-ray Diffraction), EDX (Energy-dispersive X-ray spectroscopy), HR-TEM (High-resolution transmission electron microscopy), FT-IR (Fourier-transform infrared spectroscopy), and FESEM (Field emission scanning electron microscopy) were applied to confirm the proper synthesis of Zn-MOF. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) approaches were employed to study the electrochemical behavior of the modified GCE and electrochemical determination of AA with high sensitivity.Results: Under the optimized conditions including the drop volume, supporting electrolyte type and concentration, buffer type and concentration, and pH, the linear range and LOD (detection limit) were acquired 2–22 μM equal to 1.211 μM respectively. Moreover, other prominent analytical features including repeatability, stability, and high reproducibility were investigated for the proposed sensing platform. Additionally, the prepared sensor was effectively utilized for determination of AA in human plasma samples, attaining a recovery of 93.1%.Conclusion: These findings clearly confirm that the developed Zn-based MOF/MWCNT sensing assay is a promising platform for accurate and effective AA determination in real biological samples, and confirms its potential for feasible biomedical applications.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Ascorbic acid, Electrochemical sensing assay, Zn-based Metal-organic framework, Multi-walled carbon nanotubes, Modified electrodes</keyword>
				<start_page>417</start_page>
				<end_page>429</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27863.html</web_url>
			<author_list><author>
				<first_name>Soraya</first_name>
				<middle_name></middle_name>
				<last_name>Jalali</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jalalisoraya15@gmail.com</email>
				<code>122495</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Ta.C., Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jafar</first_name>
				<middle_name></middle_name>
				<last_name>Abolhasani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dj.abul@yahoo.com</email>
				<code>122496</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Chemistry, Ta.C., Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hessamaddin</first_name>
				<middle_name></middle_name>
				<last_name>Sohrabi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hesamsoh@gmail.com</email>
				<code>122497</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sohrab</first_name>
				<middle_name></middle_name>
				<last_name>Ershad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sohrabsd@yahoo.com</email>
				<code>122498</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Payame Noor University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Behrouz</first_name>
				<middle_name></middle_name>
				<last_name>Vahid</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>behrouz.vahid@gmail.com</email>
				<code>122499</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemical Engineering, Ta.C., Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hyaluronic acid-modified PLGA nanoparticles encapsulating METTL14 siRNA enhance sunitinib sensitivity in drug-resistant renal cell carcinoma</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Sunitinib resistance remains a major obstacle in the treatment of renal cell carcinoma (RCC). This study sought to construct a targeted nanoparticle-based delivery system for silencing methyltransferase-like 14 (METTL14), with the aim of restoring drug responsiveness in resistant RCC.Methods: Hyaluronic acid-functionalized poly (lactic-co-glycolic acid) nanoparticles (HA-PLGA-NPs) were engineered to encapsulate METTL14 siRNA. Their physicochemical characteristics, targeting capability toward CD44-positive sunitinib-resistant RCC cells (786-O-SUR and ACHN-SUR), and therapeutic performance were systematically evaluated in vitro. Transcriptomic analysis was conducted to investigate underlying mechanisms. Antitumor efficacy and biosafety were further examined in a xenograft mouse model.Results: The fabricated nanoparticles displayed uniform morphology, appropriate particle size, and high siRNA encapsulation efficiency (&gt;88%), along with favorable stability. HA modification significantly improved cellular uptake in CD44-positive resistant cells compared with non-targeted nanoparticles. Delivery of METTL14 siRNA via HA-PLGA-NPs markedly reduced the IC50 of sunitinib, increased apoptotic cell death, and effectively reversed drug resistance. In vivo, treatment with HA-PLGA (METTL14 siRNA)-NPs led to substantial tumor growth inhibition. RNA sequencing indicated that METTL14 silencing was associated with pathways involved in apoptosis, cell cycle regulation, and immune-related processes. No obvious systemic toxicity was observed.Conclusion: HA-PLGA nanoparticles provide an effective and selective platform for METTL14 siRNA delivery, enabling reversal of sunitinib resistance in RCC models. This approach offers a potential therapeutic strategy for overcoming drug resistance in renal cell carcinoma.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Renal cell carcinoma, Drug resistance, Nanoparticles, RNA, Small Interfering, Methyltransferases</keyword>
				<start_page>430</start_page>
				<end_page>441</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27772.html</web_url>
			<author_list><author>
				<first_name>Yue</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gaoyue0549@163.com</email>
				<code>122092</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xuelian</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1025618604@qq.com</email>
				<code>122094</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lei</first_name>
				<middle_name></middle_name>
				<last_name>Cui</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18895304947@163.com</email>
				<code>122093</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pengcheng</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>122102</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fang</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>398370868@qq.com</email>
				<code>122095</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Baobao</first_name>
				<middle_name></middle_name>
				<last_name>Fu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18755453135@163.com</email>
				<code>122096</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chenchen</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>191219489@qq.com</email>
				<code>122097</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qianqian</first_name>
				<middle_name></middle_name>
				<last_name>Jia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>978108646@qq.com</email>
				<code>122098</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hongjiang</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1076884339@qq.com</email>
				<code>122099</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jin</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18255450971@163.com</email>
				<code>122100</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yong</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wangyong2095@163.com</email>
				<code>122101</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Oncology, The First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Rilpivirine-loaded solid lipid nanoparticles: preparation, characterization, and in vivo evaluation for enhancing oral bioavailability</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study aimed to improve the oral bioavailability of Rilpivirine by creating and testing Rilpivirine solid lipid nanoparticles (SLNs) to determine the impact of drug delivery on pharmacokinetics following oral treatment in Wistar rats.Materials and Methods: Solid lipid nanoparticles (SLNs) were fabricated using a high-pressure homogenization technique, after which they were evaluated for their physicochemical properties including particle size, morphology, zeta potential, encapsulation efficiency as well as their in vitro release behaviour, ex vivo permeability, and in vivo pharmacokinetics in Wistar rats. To further understand how SLNs are taken up through the lymphatic system, an ex vivo study was carried out using an everted rat intestinal sac model.Results: The resulting SLNs were spherical, showing an average particle size of 74.45 ± 0.84 nm with a PDI of 0.27, zeta potential -17.49 ± 0.82 mV, and an entrapment efficiency of 62.9 ± 1.2%. The SLN formulation demonstrated 84% drug release over a 24-hour period. In an ex vivo study using everted rat intestine, the SLN&#039;s apparent permeability was 34.2 × 10-6 at 37 ± 0.5 °C without chlorpromazine. This value decreased to 14.6 × 10-6 when chlorpromazine was present. Pharmacokinetic studies in rats showed the SLN formulation&#039;s AUC was 1.04 times higher than that of the pure drug suspension. Conversely, adding the lymphatic uptake inhibitor chlorpromazine reduced the SLN&#039;s AUC by 0.52-fold. The in vivo pharmacokinetic data was assessed by Dunnett&#039;s test, which indicated a significant difference (p &lt; 0.05) between the RLV SLNs and the plain RLV drug.Conclusion: Employing SLNs as a delivery vehicle appears to be a viable method for boosting the therapeutic efficacy of rilpivirine. A key reason is that SLN lymphatic uptake is important for avoiding hepatic first-pass metabolism.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Rilpivirine, Bioavailability, Lymphatic uptake, Solid lipid nanoparticles, permeability, solubility</keyword>
				<start_page>442</start_page>
				<end_page>454</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27871.html</web_url>
			<author_list><author>
				<first_name>Mangesh</first_name>
				<middle_name></middle_name>
				<last_name>Bhalekar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mrbhalekar@gmail.com</email>
				<code>122534</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, AISSMS College of Pharmacy, Pune, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ashwini</first_name>
				<middle_name></middle_name>
				<last_name>Madgulkar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>armadgulkar@gmail.com</email>
				<code>122535</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, AISSMS College of Pharmacy, Pune, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Aditi</first_name>
				<middle_name></middle_name>
				<last_name>Pande</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aditimp1999@gmail.com</email>
				<code>122536</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, AISSMS College of Pharmacy, Pune, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chetashri</first_name>
				<middle_name></middle_name>
				<last_name>Patil</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vidhidagade07@gmail.com</email>
				<code>122537</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, AISSMS College of Pharmacy, Pune, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name>Sadik</middle_name>
				<last_name>Mulla</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryammulla89@gmail.com</email>
				<code>122533</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmaceutics, AISSMS College of Pharmacy, Pune, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic nanomedicine: Catechin@Cerium-hydroxyapatite nanoparticles for oxidative stress mitigation and concurrent osteosarcoma ablation and Osteogenesis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): A significant problem in osteosarcoma treatment and bone regeneration is the creation of biomaterials that efficiently target cancer cells while concurrently facilitating bone tissue regeneration. We introduce an innovative dual-action nanomedicine, catechin-functionalized nano cerium-hydroxyapatite (CH@Ce-HA), aimed at addressing these constraints by integrating cytotoxic and regenerative capacity.Materials and Methods: The CH@Ce-HA composite was created by integrating the natural anticancer and antioxidant compound, catechin, onto a nanoscale cerium-doped hydroxyapatite matrix. The physicochemical analysis via FT-IR revealed the incorporation of catechin, while XRD validated the retention of the HA crystalline structure. TEM examination demonstrated a homogeneous distribution of nanoparticles ranging from 20 to 50 nm in size. The combined therapeutic efficacy was further examined in vitro utilizing osteosarcoma and osteoblast cell lines, evaluating cell proliferation, oxidative stress reduction, apoptosis induction, and osteogenic differentiation.Results: In vitro investigations utilizing osteosarcoma and osteoblast cell lines demonstrated the nanocomposite&#039;s exceptional therapeutic flexibility. The CH@Ce-HA demonstrated improved antioxidant activity and a strong nanomedicine effect against MG63 osteosarcoma cells, markedly suppressing proliferation, diminishing harmful oxidative stress, and effectively inducing apoptosis. The nanocomposite significantly improved osteoblast proliferation, differentiation, and mineralization.Conclusion: This study presents a potential, multifunctional ceramic based therapeutic agent that functions at the nanoscale to offer a comprehensive treatment for bone oncology. The CH@Ce-HA nanocomposite integrates targeted cytotoxic effects with robust osteogenic and antioxidant properties, marking a notable progress in translational nanomedicine treating challenging bone abnormalities and cancers.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Osteosarcoma, Bone Repair, Catechin, Osteoblast proliferation, Anti-oxidant activity</keyword>
				<start_page>455</start_page>
				<end_page>468</end_page>
				<web_url>https://nmj.mums.ac.ir/article_27949.html</web_url>
			<author_list><author>
				<first_name>Panduranga Mounagurusamy</first_name>
				<middle_name></middle_name>
				<last_name>Siva Subramanian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sivasubramanianp82@gmail.com</email>
				<code>122894</code>
				<coreauthor>No</coreauthor>
				<affiliation>SSM Institute of Engineering and Technology, Dindigul, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lakshmi Pandian</first_name>
				<middle_name></middle_name>
				<last_name>Ananthbalaji</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ananthbalaji1974@gmail.com</email>
				<code>122895</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biotechnology, Erode Sengunthar Engineering College (Autonomous), Thudupathi, Erode, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Suriyan</first_name>
				<middle_name></middle_name>
				<last_name>Sulochana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shreekisanth@gmail.com</email>
				<code>122896</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Christian College of Engineering and Technology, Oddanchatram, Dindigul, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Christopher Joseph</first_name>
				<middle_name></middle_name>
				<last_name>Kirubaharan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kirubaharanmku@gmail.com</email>
				<code>122897</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Rajalakshmi Institute of Technology, Poonamalle, Chennai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Thiru</first_name>
				<middle_name></middle_name>
				<last_name>Selvan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>selvanthirudr@gmail.com</email>
				<code>122898</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Forestry and Biodiversity, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Subramani</first_name>
				<middle_name></middle_name>
				<last_name>Rajapandi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rajapandichemistry@esec.ac.in</email>
				<code>122893</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Chemistry, Erode Sengunthar Engineering College (Autonomous), Thudupathi, Erode, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Investigating nanoformulations for the oral delivery of resveratrol to inhibit first-pass metabolism and enhance drug bioavailability</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Poor oral bioavailability remains a major barrier for the development of many therapeutic agents, underscoring the need for advanced delivery systems. This study aimed to design and evaluate novel nanoformulations of resveratrol (RSV) to improve its absorption and investigate their effects on CYP3A4 inhibition in rats and enhancing simvastatin bioavailability. Materials and Methods: An oil-in-water nanoemulsion incorporating RSV were synthesized in the oil phase (NE-RSV) and resveratrol-coated gold nanoparticles as a water-soluble form (GNP-RSV). Accordingly, a combined formulation (NE-RSV + GNP-RSV) with maximum RSV loading was prepared and physicochemically characterized. Particle size was measured using Dynamic Light Scattering, and cytotoxicity was assessed on Caco-2 cells via MTT assay. Transport studies across Caco-2 monolayers were performed to examine P-glycoprotein (P-gp) inhibition. Protein expression of CYP3A was assessed through Western blot analysis within liver microsomal preparations. Simvastatin bioavailability in rats was quantified using HPLC following 7-day oral administration. Hematological and biochemical safety markers were also analyzed. Results: Mean particle sizes were 11.3 ± 6.8 nm for NE-RSV, 22.7 ± 14.3 nm for GNP-RSV, and 36.4 ± 23.0 nm for the combined system. Cytotoxicity results showed no significant reduction in cell viability. Permeability assays confirmed P-gp inhibition. The combined formulation increased simvastatin AUC₀–₂₄ by 2.7-fold and Cmax by 3.05-fold versus controls, with no adverse changes in blood parameters or liver enzymes at 300 mg/kg. Conclusion: Nanoformulation of resveratrol led to a measurable increase in oral exposure, supporting its applicability for improving absorption of compounds with solubility-limited bioavailability.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>CYP3A, Resveratrol, Nanoemulsion, Pharmacokinetic, Oral delivery</keyword>
				<start_page>469</start_page>
				<end_page>485</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28072.html</web_url>
			<author_list><author>
				<first_name>Akram</first_name>
				<middle_name></middle_name>
				<last_name>Hassanpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hasanpourakram@gmail.com</email>
				<code>123393</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Omid</first_name>
				<middle_name></middle_name>
				<last_name>Sabzevari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>omid@tums.ac.ir</email>
				<code>123394</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Toxicology &amp; Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Banafsheh</first_name>
				<middle_name></middle_name>
				<last_name>Kiani Dehkordi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>banafsheh.dehkordi@gmail.com</email>
				<code>123395</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amir</first_name>
				<middle_name></middle_name>
				<last_name>Amani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amani76@gmail.com</email>
				<code>123396</code>
				<coreauthor>No</coreauthor>
				<affiliation>Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fariba</first_name>
				<middle_name></middle_name>
				<last_name>Esmaeili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fesmaeili2010@gmail.com</email>
				<code>123397</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sharmin</first_name>
				<middle_name></middle_name>
				<last_name>Kharrazi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sh-kharrazi@tums.ac.ir</email>
				<code>123392</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>