<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Nanomedicine Journal</title>
			<title_fa></title_fa>
			<short_title>Nanomed J</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://nmj.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2322-3049</journal_id_issn>
			<journal_id_issn_online>2322-5904</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>10</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>4</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Antimicrobial nanoparticle-based wound dressings: from theory to clinical applications</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Chronic and infected wounds continue to represent a substantial clinical burden, particularly in the context of escalating antibiotic resistance, where conventional dressings frequently fail to provide adequate antimicrobial protection or to promote efficient tissue repair. Nanoparticles have emerged as promising antibacterial and wound-healing agents due to their distinctive physicochemical properties, including high surface area and controlled ion release. Among these, silver nanoparticles exhibit the most potent antimicrobial activity, whereas polymeric and lipid-based systems offer enhanced biocompatibility and sustained release characteristics. This review presents an updated and comparative analysis of antimicrobial nanoparticle-based wound dressings, encompassing metallic, polymeric, lipid-based, carbon-based, and hybrid nanomaterials. It examines their antibacterial mechanisms of action, fabrication strategies (including hydrogels, electrospinning, and three-dimensional printing), and clinical applicability. In addition, the review critically evaluates toxicity thresholds, biocompatibility considerations, regulatory frameworks, and translational challenges. By integrating recent evidence (2020–2024), including clinical case reports, this review bridges experimental findings with clinical practice and outlines future perspectives, such as the development of smart, stimuli-responsive, and environmentally sustainable nanoparticle systems for next-generation wound management.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Antibacterial agents, Nanomedicine, Nanoparticles, Wound dressings, Wound healing</keyword>
				<start_page>486</start_page>
				<end_page>510</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28269.html</web_url>
			<author_list><author>
				<first_name>Tahereh Sadat Tabatabai</first_name>
				<middle_name></middle_name>
				<last_name>Tabatabai</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>tabatabae14021@gmail.com</email>
				<code>124290</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tayebeh Sadat</first_name>
				<middle_name></middle_name>
				<last_name>Tabatabai</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>taybeh.sadat.tabatabaie1400@gmail.com</email>
				<code>124291</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vahid</first_name>
				<middle_name></middle_name>
				<last_name>Shirshahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shirshahi@gmail.com</email>
				<code>124292</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Basic Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Cetuximab antibody and fragment-engineered nanoplatforms in targeted cancer therapy and diagnosis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background:Nanotechnology serves as a promising platform in modern cancer therapy, enabling targeted drug delivery, improved bioavailability, and multifunctional treatment approaches. There are numerous molecular targets implicated in the progression of several malignancies, among which epidermal growth factor receptor (EGFR) has been pivotal role. Cetuximab is a monoclonal antibody for EGFR inhibition, has demonstrated clinical benefits; however, its therapeutic impact remains constrained by tumor penetration off-target toxicity, and resistance development.Objective:This review summarizes recent progress in cetuximab-based nanoplatforms for cancer diagnosis and therapy, highlighting their mechanisms, therapeutic performance and strategies to overcome resistance.Methods:Relevant studies were searched from credible data bases (Google Scholar, PubMed, Science Direct, Cochrane library,…) and analyzed to evaluate the design and biomedical applications of cetuximab-conjugated nanocarriers, including polymeric nanoparticles, liposomes, mesoporous silica nanoparticles, gold and iron oxide nanoparticles, dendrimers, and DNA-based nanostructures. Antibody fragment-based systems such as Fab and scFv were also considered.Results:Cetuximab functionalized nanoparticles enhanced tumor targeting, improved cellular uptake, and increased cytotoxicity compared with free drug formulations. Many systems demonstrated reduced off-target toxicity and improved pharmacokinetics. Multifunctional nanoplatforms integrating chemotherapy, gene silencing, phototherapy or imaging agents showed promising therapeutic potential. Antibody fragment modified carriers further improved tumor penetration and targeting specificity. Several studies reported effective inhibition of tumor growth and partial reversal of multidrug resistance in preclinical models.Conclusion:Cetuximab based nanoplatforms represent a promising approach for enhancing EGFR-targeted cancer therapy. Continued optimization, standardized safety assessment and clinical validation are required to turn these systems into clinical oncology practice.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cetuximab, ErbB receptors, Nanoparticles, Drug delivery systems, Neoplasms</keyword>
				<start_page>511</start_page>
				<end_page>528</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28439.html</web_url>
			<author_list><author>
				<first_name>Fariba</first_name>
				<middle_name></middle_name>
				<last_name>Esmaeili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>esmaeilif2024@gmail.com</email>
				<code>124942</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hadis</first_name>
				<middle_name></middle_name>
				<last_name>Rahimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rahimihadis.6696@gmail.com</email>
				<code>124943</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masumeh</first_name>
				<middle_name></middle_name>
				<last_name>Jalalvand</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>masumehjalalvand@gmail.com</email>
				<code>124944</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Assistant Professor of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Zand</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryam.zand7072@yahoo.com</email>
				<code>124945</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology, Zanjan University of medical sciences, Zanjan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Leila</first_name>
				<middle_name></middle_name>
				<last_name>Abkhooie</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lilaabkhooie@yahoo.com</email>
				<code>124946</code>
				<coreauthor>No</coreauthor>
				<affiliation>Assistant Professor of Molecular Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amirmasoud</first_name>
				<middle_name></middle_name>
				<last_name>Jalalvand</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amirmasoudjalalvand749@gmail.com</email>
				<code>124947</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vahide</first_name>
				<middle_name></middle_name>
				<last_name>Heydari Nazarabad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vahidehaidari@yahoo.com</email>
				<code>124948</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamed</first_name>
				<middle_name></middle_name>
				<last_name>Esmaeil Lashgarian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hamedlashkarian2@gmail.com</email>
				<code>124941</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Associate Professor of Molecular Genetics, School of Medicine, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Regulatory intelligence-driven oversight of nanomedicines: gaps in US, EU, and India</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[A regulatory framework is required for the safe and successful clinical translation of nanomedicines. Accelerated global development: the nanomedicine market had a valuation of about USD 241 billion in 2024, with projections suggesting it will grow at double-digit rates, driven by more than 1,000 active clinical trials across the globe. Several of these complex products include RNAi-based therapies and advanced liposomal formulations, all of which have received the green light from the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the years past. However, there are notable geographical differences in the definitions, standards, and methods of testing for nanosimilarity. India&#039;s 2019 Guidelines for Evaluation of Nanopharmaceuticals marked the initial step, but Implementation and capacity are still limited. Significant regulatory gaps in immunogenicity testing, bioequivalence studies, uniform characterisation, and nano-specific pharmacovigilance leave producers and regulators in the dark. This review compares methods in the US, EU, and India using recently published clearance data, clinical trial findings, and policy papers. The role of regulatory intelligence (RI) is one of the primary concerns raised.RI a strategic tool to overcome fragmentation and enable foresight in the development of nanomedicine is the systematic monitoring of evolving regulations, authorizations, and safety reports.We conclude our offering by proposing recommendations to India on how to enhance post-market surveillance, develop capacity, set up specialized reference labs, and improve regulations. These recommendations for harmonized and evidence-driven oversight of nanomedicines make significant strides in articulating global lessons to national priorities.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Nanomedicines, Regulatory affairs, FDA, EMA, CDSCO, Regulatory intelligence.</keyword>
				<start_page>529</start_page>
				<end_page>546</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28092.html</web_url>
			<author_list><author>
				<first_name>Harish</first_name>
				<middle_name></middle_name>
				<last_name>Murthyappa</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hmdvlr2015@gmail.com</email>
				<code>123482</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Prakash</first_name>
				<middle_name></middle_name>
				<last_name>Goudanavar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pgoudanavar01@gmail.com</email>
				<code>123485</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ravi Kumar</first_name>
				<middle_name>Reddy</middle_name>
				<last_name>Juturi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ravikumar.prof@accp.co.in</email>
				<code>123483</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hemanth</first_name>
				<middle_name>Prasad</middle_name>
				<last_name>Konasuru Puttaraju</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hemanthkp72@gmail.com</email>
				<code>123484</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hemanth</first_name>
				<middle_name></middle_name>
				<last_name>Boregowda</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hemanthbhemanthb1@gmail.com</email>
				<code>123486</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mallamma</first_name>
				<middle_name></middle_name>
				<last_name>Thippeswamy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mallammareddy89@gmail.com</email>
				<code>123487</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Regulatory Affairs, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>99mTc-labeled anionic linear-globular dendrimers conjugated with l-arginine as a novel radiotracer for single photon emission computed tomography of breast tumor xenografts</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Dendrimers are promising molecular imaging platforms because of their multivalency and tunable surfaces. This study synthesized a PEGylated anionic linear-globular dendrimer conjugated with L-arginine and labeled with technetium-99m (⁹⁹ᵐTc-DND-G2-Arg) as a targeted SPECT tracer for breast cancer.Materials and Methods: G2-dendrimers were synthesized via divergent esterification and conjugated to L-arginine using carbodiimide chemistry. Physicochemical characterization was performed using FTIR, FE-SEM, DLS, and LC-MS. Cell compatibility was assessed by MTT assay in Vero cells. Radiochemical purity/stability were assessed by radio thin layer chromatography. In vivo biodistribution and SPECT imaging were conducted at 5, 30, and 120 minutes post-injection in BALB/c mice with 4T1 tumors. Kinetic behavior was analyzed using a two-compartment model.Results: FTIR and LC-MS analyses verified successful L-arginine conjugation to G2-PEG-citrate-ALGD. The spherical nanoparticles (FE-SEM: 134.91 ± 15.01 nm; DLS: 202.4 nm; zeta potential: -7.3 mV) exhibited excellent cytocompatibility (&gt;95% viability). The highly pure radiolabeled conjugate (99.68%) also remained stable, exceeding 95% over one physical half-life and retaining 80-85% stability at 48 hours in PBS and serum. In vivo studies revealed specific tumor uptake (0.87 ± 0.19 %ID/g), which decreased by 31% after L-arginine blocking (p &lt; 0.05). SPECT imaging demonstrated a strong early tumor uptake (SUVmax 4.8 at 30 min) with rapid blood clearance, while kinetic modeling indicated fast tumor influx, efficient irreversible trapping, and minimal efflux.Conclusion: ⁹⁹ᵐTc-DND-G2-Arg demonstrates specific tumor targeting, favorable pharmacokinetics, and excellent in vivo stability in a preclinical xenograft model, supporting further investigation as a potential SPECT radiotracer for imaging arginine-enriched breast cancers.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Technetium, Dendrimers, Arginine, Radionuclide Imaging, Breast neoplasms</keyword>
				<start_page>547</start_page>
				<end_page>568</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28423.html</web_url>
			<author_list><author>
				<first_name>Parham</first_name>
				<middle_name></middle_name>
				<last_name>Karimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>parham.karimi1919@gmail.com</email>
				<code>124860</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mehdi</first_name>
				<middle_name></middle_name>
				<last_name>Shafiee Ardestani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shafieeardestani@gmail.com</email>
				<code>124861</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran|Research Center for Nuclear Medicine, Shariati Hospital, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Massoud</first_name>
				<middle_name></middle_name>
				<last_name>Amanlou</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amanlou@tums.ac.ir</email>
				<code>124862</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tahereh</first_name>
				<middle_name></middle_name>
				<last_name>Zadeh Mehrizi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mehrizi.t@iums.ac.ir</email>
				<code>124863</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mehdi</first_name>
				<middle_name></middle_name>
				<last_name>Mirzaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m_mirzaei@sbmu.ac.ir</email>
				<code>124864</code>
				<coreauthor>No</coreauthor>
				<affiliation>Ministry of Health and Medical Education, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmad</first_name>
				<middle_name></middle_name>
				<last_name>Javanmard</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ajm93dr@gmail.com</email>
				<code>124865</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyed Mohsen</first_name>
				<middle_name></middle_name>
				<last_name>Asghari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sm.asghari@ut.ac.ir</email>
				<code>124866</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Bioactive Rutin@Hydroxyapatite-Halloysite nanocomposites: synergistic antibacterial and osteogenic effects for bone tissue regeneration</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[The present study describes the synthesis, characterization, and in vitro biological effectiveness of a new Rutin@Hydroxyapatite-Halloysite (Ru@HA-HNT) nanocomposite for the treatment of osteomyelitis and the regeneration of bone tissue. FT-IR and XRD measurements validated the successful incorporation of rutin (Ru) without structural modification, whereas TEM and SEM demonstrated a consistent coating of spherical Hydroxyapatite (HA) particles on tubular HNTs, offering a significant surface area for Ru adsorption. Biological evaluations utilizing MC3T3-E1 pre-osteoblast cells indicated that the nanocomposite markedly improved biocompatibility and promoted proliferation of cells. The material&#039;s capacity to reduce reactive oxygen species (ROS) levels and preserve mitochondrial membrane potential (MMP) further emphasized its antioxidant characteristics and cellular stability. The nanocomposite demonstrated significant antibacterial effectiveness against Staphylococcus aureus (S.aureus), attaining a killing efficiency of 98.4% by day 14. Moreover, osteogenic assays demonstrated a significant enhancement in differentiation; by day 14, the Ru@HA-HNT group displayed ALP activity and calcium mineralization (ARS) levels that were 19% and 16% superior to the controls, respectively. Immunofluorescence studies verified the elevation of critical osteogenic markers (RUNX2, ALP, COL I, and OCN), substantiating the material&#039;s function in promoting bone formation. The findings indicate that the Ru@HA-HNT nanocomposite is an effective, multifunctional material for concurrently addressing osteomyelitis and facilitating bone tissue regeneration.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Osteomyelitis, bone regeneration, Nanocomposites, Antibacterial agents, Signal transduction</keyword>
				<start_page>569</start_page>
				<end_page>585</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28421.html</web_url>
			<author_list><author>
				<first_name>Jayasudha</first_name>
				<middle_name></middle_name>
				<last_name>Paramanithi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ssarathsaran2016@gmail.com</email>
				<code>124848</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Government Arts College for Men, Krishnagiri, Tamil Nadu, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Balakrishnan</first_name>
				<middle_name></middle_name>
				<last_name>Munisamy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>balu060889@gmail.com</email>
				<code>124849</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, Government Arts College for Men, Krishnagiri, Tamil Nadu, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bhalaji</first_name>
				<middle_name></middle_name>
				<last_name>Pudupettai Rajagopal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>prbhalaji@yahoo.in</email>
				<code>124847</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Chemistry, Government Arts College for Men, Krishnagiri, Tamil Nadu, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The safety and efficacy of platelet-derived exosomes for grade II diabetic foot ulcers in a phase I clinical trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Exosomes are extracellular vesicles derived from various cell types. Platelet-derived exosomes contain growth factors and cytokines that contribute to tissue repair. This study assessed the safety and efficacy of platelet-derived exosomes in treating diabetic foot ulcers.Materials and Methods: Platelet-derived exosomes were isolated by ultracentrifugation and subsequently characterized. Fourteen patients with diabetes and grade II diabetic foot ulcers were included in the study based on the inclusion and exclusion criteria. Exosome injections at a concentration of 50 µg/ml and a volume of 1.5 ml were administered at one-week intervals. Safety and efficacy were assessed through clinical evaluation, measurements of wound dimensions, and laboratory analyses.Results: No significant adverse clinical events or changes in laboratory test results were observed after exosome injection in the patients. None of the patients&#039; wounds in the control group healed completely within one month. However, a decrease in wound size was observed in 3 patients in the control group. In the intervention group, the wounds of two patients completely closed within one month after PLT-Exo injection, and the wound dimensions of 42.85% of the patients exhibited a decreasing trend.Conclusion: Diabetic foot ulcers remain a significant wound-healing challenge among affected patients. Because limb amputation has serious consequences, these ulcers require considerable attention, and current treatment modalities often fail. The present study highlighted the safety, efficacy, and clinical feasibility of platelet-derived exosomes. For wider clinical application, further studies under varied conditions and with larger patient groups are recommended.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Diabetic foot ulcers, Exosome, Extracellular vesicles, Wound healing</keyword>
				<start_page>586</start_page>
				<end_page>597</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28424.html</web_url>
			<author_list><author>
				<first_name>Asma</first_name>
				<middle_name></middle_name>
				<last_name>Maleki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ma.asma2015@gmail.com</email>
				<code>124867</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ensieh</first_name>
				<middle_name></middle_name>
				<last_name>Nasli Esfahani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>n.nasli@yahoo.com</email>
				<code>124868</code>
				<coreauthor>No</coreauthor>
				<affiliation>Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mina</first_name>
				<middle_name></middle_name>
				<last_name>Soufi Zoomorrod</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>minasoufi@yahoo.com</email>
				<code>124869</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shaban</first_name>
				<middle_name></middle_name>
				<last_name>Alizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alizadeh1982@gmail.com</email>
				<code>124870</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hematology, Faculty of Medical Sciences, Tehran University of medical scinces, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Camelia</first_name>
				<middle_name></middle_name>
				<last_name>Rambod</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rambod.camelia@gmail.com</email>
				<code>124871</code>
				<coreauthor>No</coreauthor>
				<affiliation>Evidence Based Medicine Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Melina</first_name>
				<middle_name></middle_name>
				<last_name>Rezvani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>melinarezvani@yahoo.com</email>
				<code>124872</code>
				<coreauthor>No</coreauthor>
				<affiliation>Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masoud</first_name>
				<middle_name></middle_name>
				<last_name>Soleimani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>soleimani.masoud@gmail.com</email>
				<code>124873</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Gastric cancer-derived nanovesicles affect the viability and effector function of an NK cell line</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Gastric cancer is characterized by high mortality rates due to its aggressive progression and immune-evasion strategies. Tumor-derived exosomes (TDEs) are nanovesicles mainly known for their role in modulating the tumor microenvironment, including the suppression of immune effector cells such as NK cells. Materials and Methods: This study aimed to assess the impact of exosomes released from the human AGS GC cell line on the viability and effector function of the NK-92 cell line. Exosomes were characterized using FE-SEM, DLS, and flow cytometry, confirming their size (approximately 109 nm) and expression of the CD63 marker. Results: Co-culture of NK-92 cells with exosomes at 30 µg/ml for 48 hours revealed a significant reduction in cell viability in the MTT assay. Quantitative real-time PCR showed increased expression of suppression markers (NKG2A, TGF-β1, and LAG-3), while ELISA indicated decreased IFN-γ production. Flow cytometry-based cell cycle analysis demonstrated increases in the sub-G1 (apoptotic) and G0/G1 phases. Conclusion: These results suggest that GC-derived exosomes may impair NK cells, potentially contributing to immune evasion and tumor progression. However, these findings were obtained using immortalized AGS and NK-92 cell lines and require validation in primary cells and in vivo models. Insights from this study could inform novel immunotherapeutic approaches targeting exosomal pathways in GC.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Gastric cancer, Tumor-derived exosomes, Natural killer cells, Immune evasion, Cytotoxicity</keyword>
				<start_page>598</start_page>
				<end_page>605</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28442.html</web_url>
			<author_list><author>
				<first_name>Tareq</first_name>
				<middle_name></middle_name>
				<last_name>Nayef AlRamadneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>t.alramadneh@ammanu.edu.jo</email>
				<code>124956</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Omar</first_name>
				<middle_name></middle_name>
				<last_name>Fadaam</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>omar.alfafaam@uoturath.edu.iq</email>
				<code>124958</code>
				<coreauthor>No</coreauthor>
				<affiliation>College of Pharmacy, Department of Pharmaceutical Sciences, AL-Turath University, Baghdad, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abdusamiyeva</first_name>
				<middle_name></middle_name>
				<last_name>Nargiza</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nargiza_abdusamiyeva@tues.uz</email>
				<code>124959</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medicine, Termez University of Economics and Service, Termez, Uzbekistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lochinbek</first_name>
				<middle_name></middle_name>
				<last_name>Matrizayev</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lochinbek.m@mamunedu.uz</email>
				<code>124960</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medicine, Mamun University Urgench, Uzbekistan.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmed</first_name>
				<middle_name></middle_name>
				<last_name>Faisal Mutee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ahmed.faisal@alnoor.edu.iq</email>
				<code>124961</code>
				<coreauthor>No</coreauthor>
				<affiliation>College of Pharmacy,Alnoor University, Mosul, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Swati</first_name>
				<middle_name></middle_name>
				<last_name>Mishra</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>swatimishra@soa.ac.in</email>
				<code>124962</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ritesh</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drritesh7211@yahoo.com</email>
				<code>124963</code>
				<coreauthor>No</coreauthor>
				<affiliation>Centre for Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Navin</first_name>
				<middle_name></middle_name>
				<last_name>Kumar Tailor</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>malikbaderalazam@gmail.com</email>
				<code>124957</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Development and physicochemical characterisation of a cremophor-free paclitaxel–calix[6]arene inclusion complex with increased apparent solubility and in vitro cytotoxicity in mia-pa-ca-2 pancreatic cancer cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): The current research focused on the development of a Cremophor-free Paclitaxel (PTX)–Calix[6]arene (C6A) inclusion complex. To determine its apparent aqueous solubility and in vitro cytotoxicity against MIA-Pa-Ca-2 pancreatic cancer cells.Materials and Methods: An optimised PTX–C6A inclusion complex (3:5 mole ratio) was synthesised through physical mixing, and the drug loading was estimated using a validated HPLC technique. The physical characterisation of the inclusion complex was performed using FTIR, DSC, XRD, FESEM, and EDX techniques. The aqueous solubility of the complexes was comparatively studied at pH 6.8 and 7.4 using the UV-visible spectrophotometer technique, and their cytotoxicity in vitro against the MIA-Pa-Ca-2 cell line was evaluated.Results: The optimised 3:5 inclusion complex (IC) showed 84.7 ± 0.2 % (n=3) drug content, which was calculated using the HPLC technique. The inclusion complex exhibited higher apparent aqueous solubility than free PTX at both pH 6.8 and 7.4, with a more pronounced enhancement at pH 6.8. XRD analysis suggested partial amorphisation of the inclusion complex, while FESEM examination revealed predominantly spherical particles with diameters ranging from approximately 45–60 nm. The FTIR spectra showed no significant variation in the characteristic absorption bands after 12 weeks of storage, indicating no detectable changes in the characteristic FTIR profile during storage. In addition, the inclusion complex showed in vitro cytotoxic activity against MIA-Pa-Ca-2 cells with an IC50 of 5.641 nM, which was better than that of PTX (6.705 nM) and C6A (9.498 nM).Conclusion: The apparent aqueous solubility of the PTX–C6A inclusion complex was slightly higher than that of PTX, accompanied by partial amorphisation of PTX. It also showed higher in vitro cytotoxic activity against MIA-Pa-Ca-2 cells as compared to free PTX. The overall anticancer activity of the inclusion complex could be affected by the intrinsic cytotoxicity of Calix[6]arene; however, further investigation is needed to confirm this contribution.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Calix[6]arene, Cremophor&amp;ndash, free formulation, Paclitaxel, Pancreatic Cancer, Supramolecular chemistry</keyword>
				<start_page>606</start_page>
				<end_page>625</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28440.html</web_url>
			<author_list><author>
				<first_name>Bina</first_name>
				<middle_name></middle_name>
				<last_name>Gidwani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>beenagidwani@gmail.com</email>
				<code>124950</code>
				<coreauthor>No</coreauthor>
				<affiliation>Columbia Institute of Pharmacy, Faculty of Pharmacy, Columbia Professional University, Raipur, Chhattisgarh, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jyoti</first_name>
				<middle_name></middle_name>
				<last_name>Sahu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jyotisahupharma@gmail.com</email>
				<code>124949</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Shri Rawatpura Sarkar Institute of Pharmacy, Durg, Chhattisgarh, India|Vishwakarma University, School of Pharmacy, Pune, Chhattisgarh, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sanjay</first_name>
				<middle_name>Kumar</middle_name>
				<last_name>Gupta</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sanjay.gupta0311@gmail.com</email>
				<code>124951</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Rungta College of Pharmaceutical Sciences and Research, Rungta International Skills University, Bhilai, Durg, Chhattisgarh, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>From date seed to functional bread: zein nanoparticles boost antidiabetic properties in an animal model</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>مقاله پژوهشی</content_type_fa>
				<content_type>Research Paper</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective (s): This study investigated the antioxidant properties of Rabbi date seed ethanolic extract, evaluated the physicochemical properties of extract-loaded zein nanoparticles, and examined the antidiabetic effects of dry lavash bread enriched with date seed powder (5%, 10%) or extract-loaded zein nanoparticles (5%, 10%) on fasting blood glucose in normal and streptozotocin-induced diabetic rats.Materials and Methods: The ethanolic extract was prepared from date seed powder via ultrasound-assisted extraction and nanoencapsulated within a zein biopolymer matrix using an antisolvent precipitation technique. Fasting blood glucose levels in male rats were monitored and quantified using a standard glucometry assay.Result: This study found that the encapsulation efficiency (EE), mean size, and Zeta potential of the zein nanoparticles loaded with the extract were equal to 95.42%, 188.35 nm, and +10.24 mV, respectively. The nanoparticles had semi-spherical morphology. The dietary intervention significantly reduced fasting blood glucose levels in both rat models. In normal control rats, the mean level decreased from 58.81 mg/dl to 35.06 mg/dl after 15 days. In diabetic rats, levels rose from a baseline of 70.47 mg/dl to 233.67 mg/dl after STZ induction, then declined to 159.67 mg/dl following 15 days of treatment with the enriched lavash bread. Conclusion: Dry lavash bread enriched with zein nanoparticles exhibited a greater potential for reducing fasting blood glucose levels in both normal and diabetic rats compared to bread enriched directly with date seed powder.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Diabetes Mellitus, Seeds, Bread, Nanoparticles, Zein</keyword>
				<start_page>626</start_page>
				<end_page>643</end_page>
				<web_url>https://nmj.mums.ac.ir/article_28240.html</web_url>
			<author_list><author>
				<first_name>Abdolvahed</first_name>
				<middle_name></middle_name>
				<last_name>Safarzaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safarzaeiabdolvahed@gmail.com</email>
				<code>124163</code>
				<coreauthor>No</coreauthor>
				<affiliation>Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran|Department of Food Science and Technology, Faculty of Agricultural Engineering, Sari Agricultural Sciences and Natural Resources University, Sari, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reza</first_name>
				<middle_name></middle_name>
				<last_name>Farahmandfar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rezafarahmand1@yahoo.com</email>
				<code>124164</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Food Science and Technology, Faculty of Agricultural Engineering, Sari Agricultural Sciences and Natural Resources University, Sari, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reza</first_name>
				<middle_name></middle_name>
				<last_name>Esmaeilzadeh Kenari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rezakenari55@gmail.com</email>
				<code>124165</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Food Science and Technology, Faculty of Agricultural Engineering, Sari Agricultural Sciences and Natural Resources University, Sari, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamed</first_name>
				<middle_name></middle_name>
				<last_name>Fanaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fanaeih@yahoo.com</email>
				<code>124167</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmad</first_name>
				<middle_name></middle_name>
				<last_name>Mehravaran</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ahmadmehravaran55@gmail.com</email>
				<code>124166</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>