A review on the applications of nanotechnology in orthodontics

Document Type: Review Paper


1 School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran

3 Department of pediatric dentistry, Faculty of dentistry, Shahid Beheshti University of medical sciences, Tehran, Iran


Objective (s): Nanotechnology has gained importance in recent years due to its ability in the enhancement of materials properties and other specifications such as antimicrobial properties. Nano-sized materials have been applied in various fields of dentistry. Nanotechnology can be employed in orthodontics to enhance the quality of treatment. In the current study, a comprehensive review is carried out on the applications of nanotechnology in orthodontics.
Materials and Methods: In the first step, various databases such as Scopus, Google Scholar and Pubmed were searched by using appropriate keywords for the present study. Afterwards, the related resources were selected to be reviewed. Finally, the key findings of the reviewed studies were represented and summarized.
Results: Based on the reviewed researches, nanotechnology is applicable in various aspects of orthodontics. By using nanotechnology, improved properties in mechanical and medical specifications are achievable. For instance, by using nano coating in archwires, the friction force between components can be reduced and facilitate its motion. In addition, adding some types of nano particles to the composites resulted in improvement in tensile and shear bond strength. Antimicrobial properties of specific nano particles such as silver makes them favorable for reducing microorganisms in orthodontics treatment. Moreover, nanotechnology can be used in nano-identation test to assess the tools employed in orthodontics.
Conclusion: nanotechnology can be broadly employed in orthodontics to achieve better treatment including improved strength of utilized materials, more accurate positioning and reduced microorganisms.


1.Karimi-Maleh H, Fallah Shojaei A, Karimi F, Tabatabaeian K. Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery. J Nanostructures. 2018.
2. Fathollahipour S, Ghaee A, Abouei Mehrizi A, Koosha M. Controlled Antibiotic Delivery by Gelatin Nanospheres: Optimization, Characterization and Antibacterial Evaluation. J Nanostructures. 2016; 6(4): 285–292.
3.Mohamadian F, Eftekhar L, Haghighi Bardineh Y. Applying GMDH artificial neural network to predict dynamic viscosity of an antimicrobial nanofluid. Nanomedicine J. 2018; 5(4): 217–221.
4.Esmaeili J, Mohammadjafari AR. Increasing flexural strength and toughness of cement mortar using multi-walled Carbon nanotubes. Int J Nano Dimens. 2018; 5(0): 399–407.
5.Parvaneh V, Shariati M, Nezakati A. Statistical analysis of the parameters influencing the mechanical properties of layered MWCNTs/PVC nanocomposites. Int J Nano Dimens. 2015; 6(5): 509–516.
6.Alhuyi Nazari M, Ahmadi MH, Ghasempour R, Shafii MB. How to improve the thermal performance of pulsating heat pipes: A review on working fluid. Renew Sustain Energy Rev 2018; 91: 630–638.
7.Ahmadi MH, Mirlohi A, Nazari MA, Ghasempour R. A review of thermal conductivity of various nanofluids. J Mol Liq. 2018;
8.Nazari MA, Ghasempour R, Ahmadi MH, Heydarian G, Shafii MB. Experimental investigation of graphene oxide nanofluid on heat transfer enhancement of pulsating heat pipe. Int Commun Heat Mass Transf. 2018; 91: 90–94.
9.Mombeini M, Saki G, Khorsandi L, Bavarsad N. Effects of Silymarin-Loaded Nanoparticles on HT-29 Human Colon Cancer Cells. Medicina (B Aires). 2018;54(1):1.
10.Fazel-Ghaziyani M, Shahbazi-Gahrouei D, Pourhassan-Moghaddam M, Baradaran B, Ghavami M. Targeted detection of the cancer cells using the anti-CD24 bio modified PEGylated gold nanoparticles: the application of CD24 as a vital cancer biomarker. J Nanomedicine. 2018; 5(3): 172–179.
11.Zabihzadeh M, Hoseini-Ghahfarokhi M, Bayati V, Teimoori A, Ramezani Z, Assarehzadehgan M-A, Pishghadam M. Enhancement of radio-sensitivity of colorectal cancer cells by gold nanoparticles at 18 MV energy. Nanomedicine J. 2018; 5(2): 111–120.
12.Sharan J, Singh S, Lale S V, Mishra M, Koul V, Kharbanda OP. Applications of Nanomaterials in Dental Science: A Review. J Nanosci Nanotechnol. 2017; 17(4): 2235–2255.
13.Hamid Reza Ghorbani. The study of anticariogenic effect of Silver nanoparticles for dental applications. Int J Nano Dimens. 2017; 8(4): 361–364.
14.Danelon M, Pessan JP, Neto FNS, de Camargo ER, Delbem ACB. Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study. J Dent. 2015; 43(7): 806–813.
15.Akbarianrad N, Mohammadian F, Alhuyi Nazari M, Rahbani Nobar B. Applications of nanotechnology in endodontic: A Review. Nanomedicine J. 2018; 5(3): 121–126.
16.Kavaliauskienė A, Šidlauskas A, Zaborskis A. Demographic and social inequalities in need for orthodontic treatment among schoolchildren in Lithuania. Medicina (B Aires). 2010; 46(11): 767.
18.Govindankutty D. Applications of nanotechnology in orthodontics and its future implications : A review. Int J Appl Dent Sci. 2015; 1(4): 166–171.
19.Batra P, Mushtaq A, Mazumder J, Rizvi MS, Miglani R, Orth M. Nanoparticles and their Applications in Orthodontics. Adv Dent Oral Heal. 2016; 2(2): 1–10.
20.Uysal T, Yagci A, Uysal B, Akdogan G. Are nano-composites and nano-ionomers suitable for orthodontic bracket bonding? Eur J Orthod. 2010; 32(1): 78–82.
21.Mousavi SM, Shamohammadi M, Rastegaar Z, Skini M, Rakhshan V. Effect of esthetic coating on surface roughness of orthodontic archwires. Int Orthod. 2017; 15(3): 312–321.
22.Tahmasbi S, Ghorbani M, Sheikh T, Yaghoubnejad Y. Galvanic Corrosion and Ion Release from Different Orthodontic Brackets and Wires in Acidic Artificial Saliva: Part I. Shahid Beheshti Univ Dent J. 2014; 32(1): 37–44.
23.Tahmasbi S, Sheikh T, Hemmati YB. Ion Release and Galvanic Corrosion of Different Orthodontic Brackets and Wires in Artificial Saliva. J Contemp Dent Pract. 2017; 18(3): 222–227.
24.Mikulewicz M, Gronostajski Z, Wielgus A, Chojnacka K. Transparent orthodontic archwires: A systematic literature review. Arch Civ Mech Eng. 2017; 17(3): 651–657.
25.Małkiewicz K, Sztogryn M, Mikulewicz M, Wielgus A, Kamiński J, Wierzchoń T. Comparative assessment of the corrosion process of orthodontic archwires made of stainless steel, titanium–molybdenum and nickel–titanium alloys. Arch Civ Mech Eng. 2018; 18(3): 941–947.
26.Arango S, Peláez-Vargas A, García C. Coating and Surface Treatments on Orthodontic Metallic Materials. Coatings. 2012; 27: 3(1): 1–15.
27.Huja S, Kluemper GT, Morford L. Nanotechnology in Orthodontics–1: The Past, Present, and a Perspective of the Future. Nanobiomaterials Clin Dent. 2013; 231–247.
28.Katz A, Redlich M, Rapoport L, Wagner HD, Tenne R. Self-lubricating coatings containing fullerene-like WS2 nanoparticles for orthodontic wires and other possible medical applications. Tribol Lett. 2006; 21(2): 135–139.
29.Syed SS, Kulkarni D, Todkar R, Bagul RS, Parekh K, Bhujbal N, A BN. Nanocoating of archwires… Syed SS et al Original Research Conflicts of Interest: None Source of Support: Nil A Novel Method of Coating Orthodontic Archwires with Nanoparticles. J Int Oral Heal. 2015; 7(5): 30–33.
30.M. KMDBEFK. Deposition of ZnO nano particles on stainless steel orthodontic wires by chemical solution method for friction reduction propose. 2018.
31.Hosseinzadeh-Nik T, Karimzadeh A, Ayatollahi MR. Bond strength of a nano-composite used for bonding ceramic orthodontic brackets. Mater Des. 2013; 51: 902–906.
32.Asiry MA, AlShahrani I, Alaqeel SM, Durgesh BH, Ramakrishnaiah R. Effect of two-step and one-step surface conditioning of glass ceramic on adhesion strength of orthodontic bracket and effect of thermo-cycling on adhesion strength. J Mech Behav Biomed Mater. 2018; 84: 22–27.
33.Kumar RR, Kaur M, Miglani A. Contemporary orthodontic bonding adhesives - An in vitro Study. J Pierre Fauchard Acad. 2011; 25(3): 144–148.
34.Chalipa J, Akhondi MSA, Arab S, Kharrazifard MJ, Ahmadyar M. Evaluation of shear bond strength of orthodontic brackets bonded with nano-filled composites. J Dent (Tehran). 2013; 10(5): 461–465.
35.Akhavan A, Sodagar A, Mojtahedzadeh F, Sodagar K. Investigating the effect of incorporating nanosilver/nanohydroxyapatite particles on the shear bond strength of orthodontic adhesives. Acta Odontol Scand. 2013; 71(5): 1038–1042.
36.Felemban NH, Ebrahim MI. The influence of adding modified zirconium oxide-titanium dioxide nano-particles on mechanical properties of orthodontic adhesive: an in vitro study. BMC Oral Health. 2017; 17(1): 43.
37.Degrazia FW, Genari B, Leitune VCB, Arthur RA, Luxan SA, Samuel SMW, Collares FM, Sauro S. Polymerisation, antibacterial and bioactivity properties of experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes. J Dent. 2018; 69: 77–82.
38.Borzabadi-Farahani A, Borzabadi E, Lynch E. Nanoparticles in orthodontics, a review of antimicrobial and anti-caries applications. Acta Odontol Scand. 2014; 72(6): 413–417.
39.Mani SK, Saroja M, Venkatachalam M, Rajamanickam T. Antimicrobial Activity and Photocatalytic Degradation Properties of Zinc Sulfide Nanoparticles Synthesized by Using Plant Extracts. J Nanostructures. 2018; 8(2): 107–118.
40.Pansambal S, Deshmukh K, Savale A, Ghotekar S, Pardeshi O, Jain G, Aher Y, Pore D. Phytosynthesis and Biological Activities of Fluorescent CuO Nanoparticles Using Acanthospermum hispidum L. Extract. J Nanostructures. 2017; 7(3): 165–174.
41.Mirhashemi A, Bahador A, Kassaee M, Daryakenari G, Ahmad-Akhoundi M, Sodagar A. Antimicrobial Effect of Nano-Zinc Oxide and Nano-Chitosan Particles in Dental Composite Used in Orthodontics. J Med Bacteriol. 2015; 2(3–4): 1–10.
42.Poosti M, Ramazanzadeh B, Zebarjad M, Javadzadeh P, Naderinasab M, Shakeri MT. Shear bond strength and antibacterial effects of orthodontic composite containing TiO2 nanoparticles. Eur J Orthod. 2013; 35(5): 676–679.
43.Metin-Gürsoy G, Taner L, Akca G. Nanosilver coated orthodontic brackets: in vivo antibacterial properties and ion release. Eur J Orthod. 2017; 39(1) :9–16.
44.Toodehzaeim MH, Zandi H, Meshkani H, Hosseinzadeh Firouzabadi A. The Effect of CuO Nanoparticles on Antimicrobial Effects and Shear Bond Strength of Orthodontic Adhesives. J Dent (Shiraz, Iran). 2018; 19(1): 1–5.
45.Sodagar A, Kassaee MZ, Akhavan A, Javadi N, Arab S, Kharazifard MJ. Effect of silver nano particles on flexural strength of acrylic resins. J Prosthodont Res. 2012; 56(2): 120–124.
46.Ghasemi T, Arash V, Rabiee SM, Rajabnia R, Pourzare A, Rakhshan V. Antimicrobial effect, frictional resistance, and surface roughness of stainless steel orthodontic brackets coated with nanofilms of silver and titanium oxide: a preliminary study. Microsc Res Tech. 2017; 80(6): 599–607.
47.da Silva DL, Santos E, de Souza Camargo S, de Oliveira Ruellas AC. Infrared spectroscopy, nano-mechanical properties, and scratch resistance of esthetic orthodontic coated archwires. Angle Orthod. 2015; 85(5): 777–783.
48.Alcock JP, Barbour ME, Sandy JR, Ireland AJ. Nanoindentation of orthodontic archwires: The effect of decontamination and clinical use on hardness, elastic modulus and surface roughness. Dent Mater. 2009; 25(8): 1039–1043.
49.Ayatollahi MR, Karimzadeh A. Nano-Indentation Measurement of Fracture Toughness of Dental Enamel. Int J Fract. 2013; 183(1): 113–118.
50.Sinha N, Kulshreshtha NM, Dixit M, Jadhav I, Shrivastava D, Bisen PS. Nanodentistry: novel approaches. Nanostructures Oral Med. 2017; 751–776.
51.Das A, Nasim I. Nanotechnology in Dentistry- A Review. J Adv Pharm Edu Res. 2017; 7(2): 43–5.
52.Shetty NJ, Swati P, David K. Nanorobots: Future in dentistry. Saudi Dent J. 2013; 25(2): 49–52.
53.Dumitrescu A-M, Dascalu C. Dental Nanorobots Small Instruments With Large potenial. Rom J Oral Rehabil V. 2011; 3(4): 77–83.