Core-shell nanoparticles for medical applications: effects of surfactant concentration on the characteristics and magnetic properties of magnetite-silica nanoparticles

Document Type: Research Paper

Authors

1 Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran

2 Department of Material Science and Engineering, Imam Hossein University, Tehran, Iran

Abstract

Objective(s): The use of cationic surface-active agents (surfactant) in the synthesis of nanoparticles, with formation of micelle, can act as a template for the formation of meso-porous silica. Changes in the concentration of surfactants can affect the structures and properties of the resulting nanoparticles.
Materials and Methods: Magnetite nanoparticles were prepared as cores using the coprecipitation method. Silica shells were formed on the prepared cores using sol-gel through the single-step process. During synthesis, cetrimonium bromide (CTAB) was used as a surfactant at low (0.1 g), medium (1 g), and high concentrations (7 g), and the effects on the properties of the nanoparticles were investigated. The core-shell nanoparticles were analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). In addition, the surface porosities of the nanoparticles were evaluated using the BET and BJH methods. The vibrating sample magnetometer (VSM) was also employed to assess the magnetic characteristics of the synthesized samples.
Results: The results of XRD indicated that the nanoparticles were composed of magnetite and silica, while the SEM and TEM images confirmed the presence of uniform spherical particles with a core-shell structure. According to the results of the VSM tests, all nanoparticles showed super-paramagnetic behaviors. Moreover, the increased concentration of CTAB led to an increment in saturation magnetization (Ms), size, and volume of the surface pores, while the specific surface area of the nanoparticles decreased.
Conclusion: According to the results, the properties of the silica shell could be adjusted in terms of pore characteristics and magnetic behavior by changing the concentration of the surfactant.

Keywords


1.Korchinski DJ, Taha M, Yang R, Nathoo N, Dunn JF. Iron oxide as an MRI contrast agent for cell tracking: Supplementary Issue. Magn. Reson. Insights. 2015; 8: S23557.
2.Kostiv U, Patsula V, Šlouf M, Pongrac IM, Škokić S, Radmilović MD, Pavičić I, Vrček IV, Gajović S, Horák D. Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4 & SiO2 core–shell nanoparticles. RSC Adv. 2017; 7(15): 8786-8797.
3.Shen L, Li B, Qiao Y. Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems. Mater. 2018; 11(2): 324-352.
4.Sutradhar KB, Amin ML. Nanotechnology in cancer drug delivery and selective targeting. ISRN Nanotechnol. 2014; 1-12.
5.Zheng YH, Cheng Y, Bao F, Wang YS. Synthesis and magnetic properties of Fe3O4 nanoparticles. Mater Res bull. 2006; 41(3): 525-529.
6.Hao R, Xing R, Xu Z, Hou Y, Gao S, Sun S. Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles. Adv Mater. 2010; 22(25): 2729-2742.
7.Xia M, Chen C, Long M, Chen C, Cai W, Zhou B. Magnetically separable mesoporous silica nanocomposite and its application in Fenton catalysis. Microporous Mesoporous Mater. 2011; 145(1-3): 217-223.
8.Deng YH, Wang CC, Hu JH, Yang WL, Fu SK. Investigation of formation of silica-coated magnetite nanoparticles via sol–gel approach. Colloids Surf A. 2005; 262(1-3): 87-93.
9.Qu L, Tie S. Mesoporous silica-coated superparamagnetic magnetite functionalized with CuO and its application as a desulfurizer. Microporous Mesoporous Mater. 2009; 117 (1-2): 402-405.
10.Yang HH, Zhang SQ, Chen XL, Zhuang ZX, Xu JG, Wang XR. Magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations. Anal Chem. 2004; 76(5): 1316-1321.
11.Bumb A, Brechbiel MW, Choyke PL, Fugger L, Eggeman A, Prabhakaran D, Hutchinson J, Dobson PJ. Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica. Nanotechnol. 2008; 19(33): 335601.
12.Knežević NŽ, Ruiz-Hernández E, Hennink WE, Vallet-Regí M. Magnetic mesoporous silica-based core/shell nanoparticles for biomedical applications. RSC Adv. 2013; 3(25): 9584-9593.
13.Niu D, Ma Z, Li Y, Shi J. Synthesis of core− shell structured dual-mesoporous silica spheres with tunable pore size and controllable shell thickness. J Am Chem Soc. 2010; 132(43): 15144-15147.
14.Castillo SI, Ouhajji S, Fokker S, Erné BH, Schneijdenberg CT, Thies-Weesie DM, Philipse AP. Silica cubes with tunable coating thickness and porosity: From hematite filled silica boxes to hollow silica bubbles. Microporous Mesoporous Mater. 2014; 195: 75-86.
15.Yang Y, Liu J, Bai S, Li X, Yang Q. Engineering the mesopores of Fe3O4@ mesosilica core–shell nanospheres through a Solvothermal post‐treatment method. Chem Asian J. 2013; 8(3): 582-587.
16.Huang S, Li C, Cheng Z, Fan Y, Yang P, Zhang C, Yang K, Lin J. Magnetic Fe3O4@ mesoporous silica composites for drug delivery and bioadsorption. J Colloid Interface Sci. 2012; 376(1): 312-321.
17.He Q, Cui X, Cui F, Guo L, Shi J. Size-controlled synthesis of monodispersed mesoporous silica nano-spheres under a neutral condition. Microporous Mesoporous Mater. 2009; 117(3): 609-616.
18.Lu X, Liu Q, Wang L, Jiang W, Zhang W, Song X. Multifunctional triple-porous Fe3O4@ SiO2 superparamagnetic microspheres for potential hyperthermia and controlled drug release. RSC Adv. 2017; 7(51): 32049-57.
19.Singh LP, Bhattacharyya SK, Mishra G, Ahalawat S. Functional role of cationic surfactant to control the nano size of silica powder. Appl Nanosci. 2011; 1(3): 117-122.
20.Singh P, Nandanwar R, Haque FZ. Effect of surfactants on synthesis of SiO2 nanopowder using sol-gel. Int. J. Adv. Electron. Comput. Eng. 2013; 2(7): 221-226.
21.Brinker CJ, Scherer GW. Sol-gel science: the physics and chemistry of sol-gel processing. Academic press; 2013.
22.Faaliyan K, Abdoos H, Borhani E, Seyyed Afghahi SS, Magnetite-silica nanoparticles with core-shell structure: single-step synthesis, characterization and magnetic behavior. J. Sol-Gel Sci. Technol.; 2018, 88(3): 609-617.
23.Dewanto AS, Kusumawati DH, Putri NP, Yulianingsih A, Sa’adah IK, Taufiq A, Hidayat N, Sunaryono S, Supardi ZA. Structure analysis of Fe3O4@SiO2 core shells prepared from amorphous and crystalline SiO2 particles. InIOP Conf. Ser.: Mater. Sci. Eng. 2018 May (Vol. 367, No. 1, p. 012010). IOP Publishing.
24.Zandipak R, Sobhanardakani S. Novel mesoporous Fe3O4/SiO2/CTAB–SiO2 as an effective adsorbent for the removal of amoxicillin and tetracycline from water. Clean Technol. Environ Policy. 2018; 1-5.
25.Duncan R, Vicent MJ, Greco F, Nicholson RI. Polymer–drug conjugates: towards a novel approach for the treatment of endrocine-related cancer. Endocr.-Relat. Cancer. 2005; 12 (Supplement 1): S189-S199.
26.Colombo M, Carregal-Romero S, Casula MF, Gutierrez L, Morales MP, Boehm IB, Heverhagen JT, Prosperi D, Parak WJ. Biological applications of magnetic nanoparticles. Chem Soc Rev. 2012; 41(11): 4306-4334.
27.Kolhatkar AG, Jamison AC, Litvinov D, Willson RC, Lee TR. Tuning the magnetic properties of nanoparticles. Int J Mol Sci. 2013; 14(8): 15977-6009.
28.Wang J, Sun J, Sun Q, Chen Q. One-step hydrothermal process to prepare highly crystalline Fe3O4 nanoparticles with improved magnetic properties. Mater Res Bull. 2003; 38(7): 1113-1118.
29.Myers D. Surfactant science and technology. John Wiley & Sons; 2005: 11.
30.Slowing II, Vivero-Escoto JL, Wu CW, Lin VS. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Delivery Rev. 2008; 60(11): 1278-1288.