Effects of silver nanoparticle (Ag NP) on oxidative stress biomarkers in rat


1 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Pharmacology and Physiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

3 Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran

4 Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran



Nanotechnology and nanoparticles are increasingly recognized for their potential applications in aerospace engineering, nanoelectronics, and environmental remediation, medicine and consumer products. More importantly is the potential for the application of silver nanoparticles (Ag NPs) in the treatment of diseases that require maintenance of circulating drug concentration or targeting of specific cells or organs the aim of this study was to investigate the possible protective role of Ag NP antioxidative biomarkers in rats. Ag NPs are used to investigate the potential risks for the environment and health.  
Materials and Methods:  
Rats received Ag NP, 5, 50, 250 and 500 mg/kg/day IP. After two week of treatment, the activity of enzymatic scavengers such as glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant capacity (TAC) of blood samples were measured.  
Ag NP in 5, 50, 250 and 500 mg/kg reduced activities of CAT, SOD and increased TAC in plasma.  
In this study, Ag NP with 500mg/kg induced activities of CAT, SOD and decreased TAC. It is concluded that antioxidative properties of Ag NP is dose dependent.


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