A systematic review of gold nanoparticles as novel cancer therapeutics

Document Type: Review Paper

Authors

1 Department of Radiotherapy Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

2 Researcher and general practitioner, Tehran University of Medical Sciences, Tehran, Iran

10.7508/nmj.2015.04.001

Abstract

Objective(s):
The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy.
 
Materials and Methods:
This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies.
Any study that assessed nanoparticles, candidate of radio enhancement at radiotherapy on animals or cell lines was included by two independent reviewers.
 
Results:
Gold nanoparticles can enhance radiosenstivity of tumor cells. This effect is shown in vivo and in vitro, at kilovoltage or megavoltage energies, in 15 reviewed studies. Emphasis of studies was on gold nanoparticles. Radiosensitization of nanoparticles depend on nanoparticles’ size, type, concentration, intracellular localization, used irradiation energy and tested cell line. 
 
Conclusion: 
Study outcomes have showed that gold nanoparticles have been beneficial at cancer radiation therapy.

Keywords


1. Grodzinski P, Silver M, Molnar LK. Nanotechnology for cancer diagnostics: promises and challenges. Expert Rev Mol Diagn. 2006; 6: 307–318.

2. Patra C, Bhattacharya R, Mukhopadhyay D, Mukherjee P. Application of gold nanoparticles for targeted therapy in cancer.J. Biomed Nanotechnol. 2008; 4: 99–132.

3. Mahdihassan S. Alchemy, Chinese versus Greek, an etymological approach: a rejoinder. Am J Chin Med. 1998; 16: 83–86.

4. Bhattacharya R, Patra CR, Earl A, Wang S, Katarya A, Lu L, Kizhakkedathu JN, Yaszemski M, Greipp PR, Mukhopadhyay D, Mukherjee P. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells. Nanomed Nanotechnol Biol Med. 2007; 3: 224–238.

5. Hainfeld J.F.,Slatkin D.N., Focella T.M., Smilowitz H.M. Gold nanoparticles: a newX-ray contrast agent. Br J Radiol. 2006; 79: 248–253.

6. Hall EJ, Giaccia AJ. Radiobiology for the Radiologist. Sixth Edition. Philadelphia: Lippincott Williams & Wilkins; 2006.

7. Delaney G, Jacob J, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer. 2005; 104 (6): 1129–1137.

8. Khan FM. The physics of radiation therapy. Fourth edition. Philadelphia: Lippincott Williams &Wilkins; 2003.

9. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLOS Med. 2009; 6 (7): doi:10.1371/journal.pmed.1000097

10. Lechtman E, Mashouf S, Chattopadhyay N, Keller BM, Lai P, Cai Z, et al. A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness. Phys Med Biol. 2013; 58(10): 3075-3087.

11. Rahman WN, Bishara N, Ackerly T, He CF, Jackson P, Wong C, et al. Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy. Nanomedicine. 2009; 5(2):136-142.

12. Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol. 2004; 49(18): 309-315.

13. Hainfeld JF, Dilmanian FA, Zhong Z, Slatkin DN, Kalef-Ezra JA, Smilowitz HM. Gold nanoparticles enhance theradiation therapy of a murine squamous cell carcinoma. Phys Med Biol. 2010; 55: 3045–3059.

14. Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL. Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice. Cancer Sci. 2008; 99(7): 1479-1484.

15. Jain S, Coulter JA, Hounsell AR, Butterworth KT, McMahon SJ, Hyland WB, et al. Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys. 2011; 79(2): 531-539.

16. Joh DY, Sun L, Stangl M, Al Zaki A, Murty S, Santoiemma PP, et al. Selective Targeting of Brain Tumors with Gold Nanoparticle-Induced Radiosensitization. PLoS ONE 2013; 8(4): e62425.

17. Liu CJ, Wang CH, Chen ST, Chen HH, Leng WH, Chien CC, et al. Enhancement of cell radiation sensitivity by pegylated gold nanoparticles. Phys Med Biol. 2010; 55(4): 931-945.

18. Roa W, Zhang X, Guo L, Shaw A, Hu X, Xiong Y, et al. Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle. Nanotechnology. 2009; 20(37): 375101. doi: 10.1088/0957-4484/20/37/375101.

19. Kaura H, Pujaria G, Semwalb MK, Sarmaa A, Kumar Avasthi D. In vitro studies on radiosensitization effect of glucose capped gold nanoparticles in photon and ion irradiation of HeLa cell. Nucl Instr Meth Phys Res. 2013; 301: 7–11.

20. Wang C, Li X, Wang Y, Liu Zh, Fu L, Hu L. Enhancement of radiation effect and increase of apoptosis in lung cancer cells by thio-glucose-bound goldnanoparticles at megavoltage radiation energies. J Nanopart Res. 2013; 15: 1642. doi: 10.1007/s11051-013-1642-1

21. Geng F, Song K, Xing JZ, Yuan C, Yan S, Yang Q, et al. Thio-glucose bound gold nanoparticles enhance radiocytotoxic targeting of ovarian cancer. Nanotechnology. 2011; 22(28): 285101. doi: 10.1088/0957-4484/22/28/285101.

22. Zhang X, Xing JZ, Chen J, Ko L, Amanie J, Gulavita S, et al. Enhanced radiation sensitivity in prostate cancer by goldnanoparticles. Clin Invest Med. 2008; 31: E160-167.

23. Kong T, Zeng J, Wang X, Yang X, Yang J, McQuarrie S, et al.Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small. 2008; 4(9): 1537-1543.

24. Chithrani DB, Jelveh S, Jalali F, van Prooijen M, Allen C, et al. Gold nanoparticles as a radiation sensitizer in cancer therapy. Radiat Res. 2010; 173(6): 719-728.

25. Mesbahi A, Jamali F, Garehaghaji N. Effect of Photon Beam Energy, Gold Nanoparticle Size and Concentration on the Dose Enhancement in Radiation Therapy. Bioimpacts. 2013; 3(1): 29-35.

26. Brun E, Sanche L, Sicard-Roselli C. Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution. Colloids Surf B: Biointerfaces. 2009; 72: 128–134.

27. Leung MK, Chow JC, Chithrani BD, Lee MJ, Oms B, Jaffray DA. Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production. Med Phys. 2011; 38(2): 624-631.

28. Chithrani BD, Ghazani AA, Chan WC. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 2006; 6: 662–668.

29. Hainfeld JF, Dilmanian FA, Slatkin DN, Smilowitz HM. Radiotherapy enhancement with gold nanoparticles. J Pharm Pharmacol. 2008; 60(8): 977-985.

30. Choi CHJ, Alabi CA, Webster P, Davis ME. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci. 2010; 107: 1235-1240.

31. Jeremic B, Aguerri AR, Filipovic N. Radiosensitization by gold nanoparticles.

Clinical and Translational Oncology. 2013; 15(8): 593-601.

32. Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. Cell selective response to gold nanoparticles. Nanomedicine. 2007; 3(2): 111-119.

33. Turner J, Koumenis C, Kute TE, Planalp RP, Brechbiel MW, Beardsley D. Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood. 2005; 106(9): 3191-3199.