Advanced Materials Research Center, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Objective(s): Hardystonite (HT) has been successfully prepared by a modified sol-gel method. We hypothesized that nano-sized (HT) would mimic more efficiently the nanocrystal structure and function of natural bone apatite, owing to the higher surface area, compare to conventional micron-size (HT). Materials and Methods: The hardystonite nanopowder was prepared via a modified sol-gel method.Optimization in calcination temperature and mechanicalball milling resulted in a pure and nano-sized powder which characterized by means of scanning electron microscopy(SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and fourier transform infrared Spectroscopy (FT–IR). Results: Pure (HT) powders were successfully obtained via a simple sol-gel method followed by calcination at1150 °C. Mechanical grinding in a ceramic ball mill for 6 hours resulted in (HT) nanoparticles in the range of about 32-55nm. Conclusion: Our study suggested that nanohardystonite (NHT) might be a potential candidate by itself as a nanobioceramic filling powder or in combination with other biomaterials as a composite scaffold in bone tissue regeneration.
 Sun C, Lee JSH, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008; 1252: 12-52.
 Moffat B.A, David A.E. Yu F, Bergemann C, Ross BD, Yang VC. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials. 2008; 29: 487-496.
 Kumar CSSR, Mohammad F. Magnetic nanomaterials for hyperthermia-based therapyand controlled drug delivery. Adv Drug Deliv Rev. 2011; 63: 789-808.
 Laurant S, Dutz S, Hafeli U.O, Mahmoudi M. Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles. Adv Colloid Interface Sci. 2011; 166: 8- 23.
 Pouponeau P, Leroux JC, Soulez G, Gaboury L, Martel S. Co-encapsulationof magnetic nanoparticles and doxorubicin into iodegradable microcarriers for deep tissue targeting by vascular MRI navigation. Biomaterials. 2011; 32: 3481-3486.
 Kratz F. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. J Controlled Release. 2007; 132: 171-183.
 Wacker M, Zensi A, Kufleitner J, Ruff A, Schütz J, Stock- burger T, Marstaller T, Vogel V. A toolbox for the upscaling of ethanolic human serum albumin (HSA) desolvation. Int J Pharm. 2011; 46: 225-232.
 Longley DB, Harkin DP, Johnston P G. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev. Cancer, 2003; 3: 330-338.
 Gheisari H, Karamian E , Preparation and characterization of hydroxyapatite reinforced with hardystonite as a novel bio-nanocomposite for tissue engineering , Nanomed J. 2015; 2(1): 141-152.
 N.Y. Iwata, G.H. Lee, Y. Tokuoka, N. Kawashima, Colloids Surf B interfaces. 2004; 34: 239–245.
 Karamian E , Abdellahi M, Gheisari H , I, Fluorine-substituted HA reinforced with zircon as a novel nano-biocomposite ceramic: Preparation and characterization. Int. J. Mater. Res. 2015; 106(12): 1258-1290