Effects of Curcumin and Nanocurcumin supplementation on serum brain-derived neurotrophic factor and some complications in type 2 diabetic rats

Document Type : Research Paper

Authors

1 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

4 Nutrition Department, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Abstract

Objective(s): One of the most important neurotrophins is brain-derived neurotrophic factor (BDNF) that is closely associated with insulin resistance and Type 2 Diabetes Mellitus (T2DM). This study was done under the objective of investigating the effects of curcumin (CUR) and nano-curcumin (nCUR) on serum levels of BDNF, fasting blood sugar (FBS), water and food intake, and body weight in T2DM rats. 
Materials and Methods: Our work required the division of 48 male Wistar rats into the 6 groups of Control, diabetic, diabetic treated with two doses of CUR and nCUR (100 and 200 mg/kg), T2DM induced rats by intraperitoneal injection of Streptozotocin, and nicotinamide in the fasting state. Once the rats received nCUR and CUR doses through gavage for 28 days, their Serum level of BDNF was measured at the end of intervention period, while their body weight, FBS, and food and water intake were also examined at both onset and ending of this period.
Results: Considering the effect of curcumin and nano-curcumin administration on the induced significant increase in serum BDNF and decrease in FBS, food, and water intake in T2DM rats (P<0.05), we can confirm the superior effectiveness of nano-curcumin 100 in serum BDNF elevation than curcumin (P<0.05). It is also notable that the body weight of intervention groups did not face any significant reduction when compared to that of diabetic control group.
Conclusion: These findings provide evidence for the beneficial effects of CUR and nCUR as an antidiabetic agent, which can be potentially considered as an adjunct for the available diabetes therapies.

Keywords

References

1. Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends. J Epidemiol Glob Health. 2020;10(1):107-111.
2. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790.
3. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, et al. Type 2 diabetes mellitus. Nature Reviews Disease Primers. 2015;1(1):15019.
4. Ojo O. Dietary Intake and Type 2 Diabetes. Nutrients. 2019;11(9):2177.
5. Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients. 2019;11(8):1837.
6. Oliveira S, Monteiro-Alfredo T, Silva S, Matafome P. Curcumin derivatives for Type 2 Diabetes management and prevention of complications. Arch Pharm Res. 2020;43(6):567-581.
7. Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati M. The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Phytother Res. 2019;33(5):1374-1383.
8. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50(2):431-438.
9. Rozanska O, Uruska A, Zozulinska-Ziolkiewicz D. Brain-Derived Neurotrophic Factor and Diabetes. Int J Mol Sci. 2020;21(3):841.
10. Sarraf P, Parohan M, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: A systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Res. 2019;69:1-8.
11. Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G. The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr. 2019;11:41.
12. Altobelli E, Angeletti PM, Marziliano C, Mastrodomenico M, Giuliani AR, Petrocelli R. Potential Therapeutic Effects of Curcumin on Glycemic and Lipid Profile in Uncomplicated Type 2 Diabetes-A Meta-Analysis of Randomized Controlled Trial. Nutrients. 2021;13(2):404.
13. Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res. 2013;57(9):1569-1577.
14. Azhdari M, Karandish M, Mansoori A. Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(5):1289-1301.
15. Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med. 2013;2013:636053.
16. Hariri M, Haghighatdoost F. Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials. J Am Coll Nutr. 2018;37(3):215-222.
17. Ghalandarlaki N, Alizadeh AM, Ashkani-Esfahani S. Nanotechnology-applied curcumin for different diseases therapy. Biomed Res Int. 2014;2014:394264.
18. Karthikeyan A, Senthil N, Min T. Nanocurcumin: A Promising Candidate for Therapeutic Applications. Front Pharmacol. 2020;11:487.
19. Shamsi-Goushki A, Mortazavi Z, Mirshekar MA, Mohammadi M, Moradi-Kor N, Jafari-Maskouni S, et al. Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats. Diabetes Metab Syndr Obes. 2020;13:2337-2346.
20. Hossaini Alhashemi S, Mohammadpour AH, Heidari R, Nikoo MH, Nemati MH, Vazin A. The effect of nanocurcumin on the incidence of atrial fibrillation, and markers of inflammation and oxidative stress level after coronary artery bypass graft surgery: A randomized, double-blind, placebo-controlled clinical study. Avicenna J Phytomed. 2022;12(5):503-513.
21. Elfving B, Plougmann PH, Wegener G. Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions. J Neurosci Methods. 2010;187(1):73-77.
22. Zou W, Yang Y, Gu Y, Zhu P, Zhang M, Cheng Z, et al. Repeated Blood Collection from Tail Vein of Non-Anesthetized Rats with a Vacuum Blood Collection System. J Vis Exp. 2017(130):55852.
23. Jiménez-Flores LM, López-Briones S, Macías-Cervantes MH, Ramírez-Emiliano J, Pérez-Vázquez V. A PPARγ, NF-κB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db/db mice liver. Molecules. 2014;19(6):8289-8302.
24. Boarescu PM, Boarescu I, Bocșan IC, Gheban D, Bulboacă AE, Nicula C, et al. Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats. Antioxidants (Basel). 2019;8(10):504.
25. Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Ghayour Mobarhan M, et al. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna J Phytomed. 2016;6(5):567-577.
26. Quispe C, Herrera-Bravo J, Javed Z, Khan K, Raza S, Gulsunoglu-Konuskan Z, et al. Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective. Biomed Res Int. 2022;2022:1375892.
27. Eyileten C, Kaplon-Cieslicka A, Mirowska-Guzel D, Malek L, Postula M. Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:2823671.
28. Skibinska M, Kapelski P, Rajewska-Rager A, Szczepankiewicz A, Narozna B, Duda J, et al. Elevated brain-derived neurotrophic factor (BDNF) serum levels in an acute episode of schizophrenia in polish women: Correlation with clinical and metabolic parameters. Psychiatry Res. 2019;271:89-95.
29. Akça İ, Bodur A, Kahraman C, Abidin İ, Aydın-Abidin S, Alver A. The regulation of adipokines related to obesity and diabetes is sensitive to BDNF levels and adipose tissue location. Hormones (Athens). 2022;21(2):295-303.
30. Xu Y, Ku B, Tie L, Yao H, Jiang W, Ma X, et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res. 2006;1122(1):56-64.
31. Kuipers SD, Bramham CR. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curr Opin Drug Discov Devel. 2006;9(5):580-586.
32. Wang R, Li YH, Xu Y, Li YB, Wu HL, Guo H, et al. Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(1):147-153.
33. Osali A. Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome. Diabetol Metab Syndr. 2020;12:26.
34. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, et al. Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. Br J Pharmacol. 2017;174(13):2074-2084.
35. Xie Z, Wu B, Shen G, Li X, Wu Q. Curcumin alleviates liver oxidative stress in type 1 diabetic rats. Mol Med Rep. 2018;17(1):103-108.
36. Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60(1):171-180.
37. Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SP. The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2020;48:102283.
38. Assis RP, Arcaro CA, Gutierres VO, Oliveira JO, Costa PI, Baviera AM, et al. Combined Effects of Curcumin and Lycopene or Bixin in Yoghurt on Inhibition of LDL Oxidation and Increases in HDL and Paraoxonase Levels in Streptozotocin-Diabetic Rats. Int J Mol Sci. 2017;18(4):332.
39. Dadgar H, Kermanshahi H, Jaafari MR, Javadmanesh A. Effects of curcumin and its nano-micelle formulation on body weight, insulin resistance, adiponectin, and blood biochemical parameters of streptozotocin-induced diabetic rats. Iranian Journal of Veterinary Science and Technology. 2022;14(3):38-45.
40. Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr. 2009;139(5):919-925.
41. Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res. 2013;27(3):374-379.
42. Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res. 2014;28(12):1770-1777.
43. Ibrahim RM, Elaal F, Zaki S. Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. Int J Food Sci Bioechnol. 2019;4:64.
Nanomedicine Journal
Volume 10, Issue 2
April 2023
Pages 123-130

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