Preparation and characterization of captopril loaded polycaprolactone electrospun nanofibers

Document Type : Research Paper


1 Department of Chemical Engineering, Faculty of Engineering, University of Zanjan, Zanjan, Iran

2 Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran



Objective(s): Electrospun nanofibrous mats of Polycaprolactone (PCL) and amino modified SBA-15 containing Captopril were prepared and release of drug from prepared nanofibers were investigated in this study.
Materials and Methods: Amino modified SBA-15 synthesized through grafting with aminopropyl triethoxy silane. Then, Captopril which is used as an Angiotensin-Converting Enzyme (ACE) inhibitor was loaded as a model drug into the synthesized particles. Furthermore, silica particles containing different amounts of captopril (7.5, 10, 15 mg) were loaded into PCL nanofibers’ structure using electrospinning. Therefore, captopril’s release rate in phosphate buffer was analyzed. The analysis of captopril-loaded silica and captopril-loaded nanofibers (without silica) was done in vitro matrix. To identify the acquired nanofibers, FTIR, SEM, SEM mapping, EDX and average diameter calculation were performed. 
Results: Comparison between the drug release rate of silica-containing nanofibers and bare silica particles indicated that silica particles positively affected the drug release rate. Moreover, kinetic studies have revealed that the drug release rate follows Higuchi and Korsmeyer-Peppas model. Bare nanofibers’ average diameter was 209 nm while silica and captopril containing nanofibers were 286 nm in average diameter. 
Conclusion: Therefore, it was concluded that drug-loaded Polycaprolactone nanofibers are potential candidates for biomedical applications.


 Ramanujam R, Sundaram B, Janarthanan G, Devendran E, Venkadasalam M, John Milton MC. Biodegradable polycaprolactone nanoparticles based drug delivery systems: A short review. Biosci Biotechnol Res Asia. 2018; 15(3):679–685. 
  Eatemadi A, Daraee H, Zarghami N, Yar HM , Akbarzadeh A. Nanofiber: Synthesis and biomedical applications. Artif Cells Nanomed Biotechnol. 2016;44(1):111–121. 
 Khalf A. Madihally SV. Modeling the permeability of multiaxial electrospun poly (ε-caprolactone)-gelatin hybrid fibers for controlled doxycycline release. Mater Sci Eng C. 2017;76:161–170. 
 Yu DG. Li XY. Wang X. Yang JH. Bligh SA. Williams GR. Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems. ACS Appl Mater Interfaces. 2015;7:18891–18897.
 Yang GZ. Li JJ. Yu DG. He MF. Yang JH. Williams GR. Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning. Acta Biomater. 2017; 53:233–241.
 Sultanova Z. Kaleli G. Kabay G. Mutlu M. Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers. Int J Pharm. 2016;505:133-138.
  Pillay V. Dott C. Choonara YE, Tyagi C, Tomar L, Kumar P, Toit LC, Valence MK. A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. J Nanomater. 2013;789289.
    Song SW, Hidajat K, Kawi S. Functionalized SBA-15 materials as carriers for controlled drug delivery: Influence of surface properties on matrix-drug interactions. Langmuir. 2005; 21:9568–9575.
   Zhao D. Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores. Science. 1998; 279:548–552.
Filipe V, Hawe A, Jiskoot W. Critical evaluation of nanoparticle tracking analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res. 2010;27:796–810.
Demadis KD, Mavredaki E. Green additives to enhance silica dissolution during water treatment. Environ Chem Lett. 2005;3:127–131. 
De La Rocha CL, Brzezinski MA, DeNiro MJ. Purification, Recovery, and Laser-Driven Fluorination of Silicon from Dissolved and Particulate Silica for the Measurement of Natural Stable Isotope Abundances. Anal Chem. 1996;68: 3746-3750.
Abadi IJZ. Sadeghi O. Lotfizhad HR. Tavassoli N. Amani V. Amini M. Novel modified nanoporous silica for oral drug delivery: loading and release of clarithromycin. J Sol–Gel Sci Technol. 2012;61:90–95.
Wang H.  Gao X. Wang Y. Wang J. Niu X. Deng X.  Effect of amine and carboxyl functionalization of sub-micrometric MCM-41 spheres on controlled release of cisplatin. Ceram Int. 2012;38:6931–6935. 
Xu Y. Wang C, Zhou G, Wu Y, Chen J. Improving the controlled release of water-insoluble emodin from amino-functionalized mesoporous silica. Appl Surf Sci. 2012;258: 6366–6372.