Preparation and characterization of electrospun apigenin-loaded polycaprolactone nanofibers for wound dressing applications

Articles in Press

Document Type : Research Paper

Authors

1 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

2 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

3 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

5 Department of Nursing and Midwifery, Estahban branch, Islamic Azad university, Estahban, Iran

6 Department of Medical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran

10.22038/nmj.2024.76451.1863

Abstract

Objective(s): This study uses the blend-electrospinning method to explore the development of apigenin)APG(-loaded PCL nanofibers as a promising wound dressing material. 
Materials and Methods: The approach combines APG’s anti-inflammatory and antioxidant properties with the advantages of nanofibers for wound healing. The research investigates the electrospinning process for optimal parameters and characterizes the resulting nanofibers using FE-SEM, FTIR, and contact angle measurements. 
Results: The findings demonstrate successful APG incorporation into PCL nanofibers at concentrations up to 0.5 wt%. The APG release profile indicates a sustained release over 48 hours. Biocompatibility and cytotoxicity assessments using the Alamar Blue assay reveal excellent biocompatibility of APG-loaded PCL nanofibers (over 90% viability). Additionally, the nanofibers exhibit a porous, bead-free structure with improved hydrophilicity due to APG incorporation. 
Conclusion: Overall, this study highlights the development of APG/PCL nanofibers with promising characteristics for wound dressing applications. The combination of APG’s therapeutic properties, sustained release profile, and biocompatible nanofiber structure suggests their potential for effective wound healing.

Keywords

References

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Articles in Press, Accepted Manuscript
Available Online from 12 August 2024

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