The future prospect of metal-organic frameworks for theranostic purposes in brain disorders

Document Type : Mini Review

Author

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10.22038/nmj.2024.77401.1888

Abstract

The burgeoning field of nanoscale metal-organic frameworks (NMOFs) has captured substantial attention within the biomedical fields, prompting a shift towards exploring their potential in diagnosis and treating brain disorders. This narrative letter delves into the limited research encompassing NMOF-mediated drug delivery to the brain for neurological conditions compared to other applications. Despite significant strides in diagnosing and treating brain ailments utilizing NMOFs, challenges persist, notably the formidable blood-brain barrier (BBB) hindrance, stability issues, and cost considerations. Enhancing NMOF efficacy requires strategic functionalization, eco-friendly synthesis methodologies, and rigorous toxicity assessments. Overcoming these obstacles involves tailoring NMOF properties for improved BBB penetration and physiochemical stability, alongside meticulous biocompatibility evaluations. To advance NMOF applications in neurological theranostics successfully, concerted efforts towards refining safety, efficiency, precise delivery, and cost-effectiveness are imperative. Addressing these challenges will pave the way for translating this promising technology into practical clinical settings, facilitating enhanced precision and efficacy in neurology.

Keywords

References

1.    He S, Wu L, Li X, Sun H, Xiong T, Liu J, et al. Metal-organic frameworks for advanced drug delivery. Acta Pharm Sin B. 2021;11(8):2362-2395.
2.    Zhao J, Yin F, Ji L, Wang C, Shi C, Liu X, et al. Development of a tau-targeted drug delivery system using a multifunctional nanoscale metal–organic framework for Alzheimer’s disease therapy. ACS Appl Mater Interfaces. 2020;12(40):44447-44458.
3.    Niu H, Bu H, Zhao J, Zhu Y. Metal–organic frameworks‐based nanoplatforms for the theranostic applications of neurological diseases. Small. 2023;19(23):2206575.
4.    Alahri MB, Arshadizadeh R, Raeisi M, Khatami M, Sajadi MS, Abdelbasset WK, et al. Theranostic applications of metal–organic frameworks (MOFs)-based materials in brain disorders: Recent advances and challenges. Inorg Chem Commun. 2021;134:108997.
5.    García-García A, Rojas S, Rodríguez-Diéguez A. Therapy and diagnosis of Alzheimer’s disease: From discrete metal complexes to metal–organic frameworks. J Mater Chem B. 2023;11(30):7024-7040.
6.    Moretti R, Pansiot J, Bettati D, Strazielle N, Ghersi-Egea J-F, Damante G, et al. Blood-brain barrier dysfunction in disorders of the developing brain. Front Neurosci. 2015;9:40.
7.    Indrit S, Şahin A, Tonbul H, Çapan Y. Brain-targeted nanoparticles to overcome the blood-brain barrier. J Pharm Technol. 2020;1(1):25-39.
8.    Kumar S, Jain S, Nehra M, Dilbaghi N, Marrazza G, Kim K-H. Green synthesis of metal–organic frameworks: A state-of-the-art review of potential environmental and medical applications. Coord Chem Rev. 2020;420:213407.
9.    Singh N, Qutub S, Khashab NM. Biocompatibility and biodegradability of metal organic frameworks for biomedical applications. J Mater Chem B. 2021;9(30):5925-5934.
10. Lai X, Jiang H, Wang X. Biodegradable metal organic frameworks for multimodal imaging and targeting theranostics. Biosensors. 2021;11(9):299.
Nanomedicine Journal
Volume 12, Issue 1
January 2025
Pages 15-17

Files

Share

How to cite

Statistics