1. Abdellatif AA, Abdelfattah A, Bouazzaoui A, Osman SK, Al-Moraya IS, Showail AMS, et al. Silver nanoparticles stabilized by poly (vinyl pyrrolidone) with potential anticancer activity towards prostate cancer. Bioinorg Chem Appl. 2022;2022:6181448.
2. Siege R, Miller K, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7-30.
3. Siegel Rebecca L, Miller Kimberly D. Jemal Ahmedin. Cancer statistics, 2019. CA: Cancer J Clin. 2019;69(1):7-34.
4. Wang B, Hu S, Teng Y, Chen J, Wang H, Xu Y, et al. Current advance of nanotechnology in diagnosis and treatment for malignant tumors. Sig Transduct Target Ther 2024;9: 200
5. Sun W, Deng Y, Zhao M, Jiang Y, Gou J, Wang Y, et al. Targeting therapy for prostate cancer by pharmaceutical and clinical pharmaceutical strategies. J Control Release. 2021;333:41-64.
6. Hojabri M, Tayebi T, Kasravi M, Aghdaee A, Ahmadi A, Mazloomnejad R, et al. Wet-spinnability and crosslinked Fiber properties of alginate/hydroxyethyl cellulose with varied proportion for potential use in tendon tissue engineering. In J Biol Macromol 2023;240:124492.
7. Noorbazargan H, Amintehrani S, Dolatabadi A, Mashayekhi A, Khayam N, Moulavi P, et al. Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells. AMB Express. 2021;11(1):61.
8. Preethi DRA, Prabhu S, Ravikumar V, Philominal A. Anticancer activity of pure and silver doped copper oxide nanoparticles against A549 Cell line. Mater Today Commun. 2022;33:104462.
9. Katarzyńska-Banasik D, Kozubek A, Grzesiak M, Sechman A. Effects of Silver Nanoparticles on Proliferation and Apoptosis in Granulosa Cells of Chicken Preovulatory Follicles: An In Vitro Study. Animals. 2021;11(6):1652.
10. Shaaban MT, Mohamed BS, Zayed M, El-Sabbagh SMJBb. Antibacterial, antibiofilm, and anticancer activity of silver-nanoparticles synthesized from the cell-filtrate of Streptomyces enissocaesilis. BMC Biotechnol 2024;24(1):1-13.
11. Andleeb A, Andleeb A, Asghar S, Zaman G, Tariq M, Mehmood A, et al. A systematic review of biosynthesized metallic nanoparticles as a promising anti-cancer-strategy. Cancers (Basel). 2021;13(11):2818.
12. Sangour MH, Ali IM, Atwan ZW, Al Ali AAAL. Effect of Ag nanoparticles on viability of MCF-7 and Vero cell lines and gene expression of apoptotic genes. Egypt J Med Hum Genet 2021;22 (9):1-11.
13. Bin-Jumah M, Al-Abdan M, Albasher G, Alarifi S. Effects of green silver nanoparticles on apoptosis and oxidative stress in normal and cancerous human hepatic cells in vitro. Int J Nanomed. 2020;15:1537-1548.
14. Moulavi P, Noorbazargan H, Dolatabadi A, Foroohimanjili F, Tavakoli Z, Mirzazadeh S, et al. Antibiofilm effect of green engineered silver nanoparticles fabricated from Artemisia scoporia extract on the expression of icaA and icaR genes against multidrug‐resistant Staphylococcus aureus. J Basic Microbiol. 2019;59(7):701-712.
15. Danciu C, Muntean D, Alexa E, Farcas C, Oprean C, Zupko I, et al. Phytochemical characterization and evaluation of the antimicrobial, antiproliferative and pro-apoptotic potential of Ephedra alata Decne. hydroalcoholic extract against the MCF-7 breast cancer cell line. Molecules. 2018;24(1):13.
16. Sioud F, Dhouafi Z, Lahmar A, Elgueder D, Chekir-Ghedira L. A novel anticancer effect of Ephedra alata Decne in breast cancer cells. Nutr Cancer. 2022;74(9):3403-3412.
17. Nasar MQ, Shah M, Khalil AT, Kakar MQ, Ayaz M, Dablool AS, et al. Ephedra intermedia mediated synthesis of biogenic silver nanoparticles and their antimicrobial, cytotoxic and hemocompatability evaluations. Inorg Chem Commun 2022;137:109252.
18. Nasar MQ, Zohra T, Khalil AT, Ovais M, Ullah I, Ayaz M, et al. Extraction optimization, Total Phenolic-Flavonoids content, HPLC-DAD finger printing, antimicrobial, antioxidant and cytotoxic potentials of Chinese folklore Ephedra intermedia Schrenk & CA Mey. Braz J Pharma Sci 2023;58.
19. Preethi DRA, Prabhu S, Ravikumar V, Philominal AJMTC. Anticancer activity of pure and silver doped copper oxide nanoparticles against A549 Cell line. Mater Today Commun 2022;33:104462.
20. Chen W, Yang W, Chen P, Huang Y, Li FJAam, interfaces. Disulfiram copper nanoparticles prepared with a stabilized metal ion ligand complex method for treating drug-resistant prostate cancers. ACS Appl Mater Interfaces 2018;10(48):41118-41128.
21. Prashanth G, Sathyananda H, Prashanth P, Gadewar M, Mutthuraju M, Prabhu SB, et al. Controlled synthesis of Ag/CuO nanocomposites: evaluation of their antimycobacterial, antioxidant, and anticancer activities. Appl Phys A 2022;128(7):614.
22. Alnuwaiser MA, Betageri VS, Khan MI, Guedri KJJotICS. Facile synthesis of silver doped-copper oxide nano materials utilizing areca catechu (AC) leaf extract and their antidiabetic and anticancer studies. J Indian Chem Soc 2022;99(9):100606.
23. Manikandan DB, Arumugam M, Sridhar A, Perumalsamy B, Ramasamy TJER. Sustainable fabrication of hybrid silver-copper nanocomposites (Ag‐CuO NCs) using Ocimum americanum L. as an effective regime against antibacterial, anticancer, photocatalytic dye degradation and microalgae toxicity. Environ Res. 2023;228:115867.
24. Afrand M, Sourinejad I, Fazeli SAS, Akbarzadeh A. Identification of Engraulids (Encrasicholina punctifer and E. pseudoheteroloba) using the COI gene as a DNA barcoding marker. J Aquatic Ecol 2018;7(3):39-47.
25. Chen J, Li S, Luo J, Wang R, Ding W. Enhancement of the antibacterial activity of silver nanoparticles against phytopathogenic bacterium Ralstonia solanacearum by stabilization. J Nanomater. 2016;2016.
26. Ng NS, Ooi L. A simple microplate assay for reactive oxygen species generation and rapid cellular protein normalization. Bio Protoc 2021;11(1):e3877
27. Akbarzadeh I, Rezaei N, Bazzazan S, Mezajin MN, Mansouri A, Karbalaeiheidar H, et al. In silico and in vitro studies of GENT-EDTA encapsulated niosomes: A novel approach to enhance the antibacterial activity and biofilm inhibition in drug-resistant Klebsiella pneumoniae. Biomater Adv. 2023;149:213384.
28. Ahmadi S, Seraj M, Chiani M, Hosseini S, Bazzazan S, Akbarzadeh I, et al. In vitro development of controlled-release nanoniosomes for improved delivery and anticancer activity of letrozole for breast cancer treatment. 2022;17:6233.
29. Akhilesh R, Amith S, Absar A, Murali S. Role of halide ions and temperature on the morphology of biologically synthesized gold nanoparticles. Langmuir. 2006;22:736-41.
30. Borchert H, Shevchenko EV, Robert A, Mekis I, Kornowski A, Grübel G, et al. Determination of nanocrystal sizes: a comparison of TEM, SAXS, and XRD studies of highly monodisperse CoPt3 particles. Langmuir. 2005;21(5):1931-1936.
31. Vidhya S, Rose AL. Microwave Assisted Green Synthesis of Gold Nanoparticles Using Bougainvillea glabra Leaf Extract. Asian J Chem. 2017;29(8).
32. Amatori S, Persico G, Fanelli M. Real-time quantitative PCR array to study drug-induced changes of gene expression in tumor cell lines. J Cancer Metastasis Treat. 2017;3(90):10.20517.
33. Nel A, Xia T, Madler L, Lin N. Ti is an abundant element in soil and appears in a variety of forms including primary and secondary minerals as well as organically bound and amorphous compounds. Sci. 2006;311:622-627.
34. Rasool S, Tayyeb A, Raza MA, Ashfaq H, Perveen S, Kanwal Z, et al. Citrullus colocynthis-mediated green synthesis of silver nanoparticles and their antiproliferative action against breast cancer cells and bactericidal roles against human pathogens. Nanomater. 2022;12(21):3781.
35. Abd El-Aziz SM, Farahat EAJJoI, Polymers O, Materials. The Activity of Vossia cuspidata Polysaccharides-Derived Monometallic CuO, Ag, Au, and Trimetallic CuO-Ag-Au Nanoparticles Against Cancer, Inflammation Wound Healing. 2023;33(3):853-865.
36. Giridasappa A, Ismail SM, Gopinath S. Antioxidant, Bactericidal, Antihemolytic, and Anticancer Assessment Activities of Al2O3, SnO2, and Green Synthesized Ag and CuO NPs. Handbook of Sustainable Materials: Modelling, Characterization, and Optimization: CRC Press; 2023367-202398.
37. Doman KM, Gharieb MM, Abd El-Monem AM, Morsi HHJIJoEHR. Synthesis of silver and copper nanoparticle using Spirulina platensis and evaluation of their anticancer activity. Int J Environ Health Res. 2024;34(2):661-673.
38. Aarya, Thomas T, Sarangi BR, Sen Mojumdar SJAo. Rapid Detection of Ag (I) via Size-Induced Photoluminescence Quenching of Biocompatible Green-Emitting, l-Tryptophan-Scaffolded Copper Nanoclusters. ACS Omega. 2023;8(16):14630-14640.
39. Jacob J, Prasad T, Vithiya B, Athisa MRJJoP, Microbiology A. Biosynthesis of Bimetallic Cu-Ag Nanocomposites and Evaluation of their Electrocatalytic, Antibacterial and Anti-Cancerous Activity. J Pure Appl Microbiol.2022;16(2):955-966
40. Botcha S, Prattipati SD. Callus extract mediated green synthesis of silver nanoparticles, their characterization and cytotoxicity evaluation against MDA-MB-231 and PC-3 cells. BioNanoSci. 2020;10:11-22.
41. Mosdam T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assay. J Immunol Methods. 1983;65:55-63.
42. Farah MA, Ali MA, Chen S-M, Li Y, Al-Hemaid FM, Abou-Tarboush FM, et al. Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species. Colloids and Surfaces B: Biointerfaces. 2016;141:158-169.
43. Rizwana H, Bokahri NA, Alfarhan A, Aldehaish HA, Alsaggabi NS. Biosynthesis and characterization of silver nanoparticles prepared using seeds of Sisymbrium irio and evaluation of their antifungal and cytotoxic activities. Green Process Synthesis. 2022;11(1):478-491.
44. Alduraihem NS, Bhat RS, Al-Zahrani SA, Elnagar DM, Alobaid HM, Daghestani MH. Anticancer and antimicrobial activity of silver nanoparticles synthesized from pods of Acacia nilotica. Processes. 2023;11(2):301.
45. Majid A, Faraj HR. Green Synthesis of Copper Nanoparticles using Aqueous Extract of Yerba Mate (llex Paraguarients St. Hill) and its Anticancer Activity. Int J NanosciNanotechnol. 2022;18(2):99-108.
46. Zughaibi TA, Mirza AA, Suhail M, Jabir NR, Zaidi SK, Wasi S, et al. Evaluation of anticancer potential of biogenic copper oxide nanoparticles (CuO NPs) against breast cancer. J Nanomater. 2022;2022:1-7.
47. Rajendran R, Mani A. Photocatalytic, antibacterial and anticancer activity of silver-doped zinc oxide nanoparticles. J Saudi Chem Soc. 2020;24(12):1010-1024.
48. Ullah I, Khalil AT, Ali M, Iqbal J, Ali W, Alarifi S, et al. Green-synthesized silver nanoparticles induced apoptotic cell death in MCF-7 breast cancer cells by generating reactive oxygen species and activating caspase 3 and 9 enzyme activities. Oxid Med Cell Longev. 2020;2020:1215395.
49. Plackal Adimuriyil George B, Kumar N, Abrahamse H, Ray SS. Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells. Scientific reports. 2018;8(1):14368.
50. Biresaw SS, Taneja P. Copper nanoparticles green synthesis and characterization as anticancer potential in breast cancer cells (MCF7) derived from Prunus nepalensis phytochemicals. Mater Today: Proceedings. 2022;49:3501-3509.
51. Mahmood RI, Kadhim AA, Ibraheem S, Albukhaty S, Mohammed-Salih HS, Abbas RH, et al. Biosynthesis of copper oxide nanoparticles mediated Annona muricata as cytotoxic and apoptosis inducer factor in breast cancer cell lines. Sci Rep. 2022;12(1):16165.
52. Aishajiang R, Liu Z, Wang T, Zhou L, Yu D. Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy. Molecules. 2023;28(5):2303.
53. Galluzzi L, Vitale I, Abrams J, Alnemri E, Baehrecke E, Blagosklonny M, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Different. 2012;19(1):107-120.
54. Zuckerkandl E, Pauling L. Evolutionary divergence and convergence in proteins. Evolving genes and proteins: Elsevier; 1965. p. 97-166.
55. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Molecular cell. 1998;1(7):949-957.
56. Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 2013;14:1-9.
57. Amaral JD, Xavier JM, Steer CJ, Rodrigues CM. The role of p53 in apoptosis. Discov Med. 2010;9(45):145-152.
58. Bao J, Jiang Z, Ding W, Cao Y, Yang L, Liu J. Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells. Nanotechnol Rev. 2022;11(1):1911-1926.
59. Kasravi M, Yaghoobi A, Tayebi T, Hojabri M, Taheri AT, Shirzad F, et al. MMP inhibition as a novel strategy for extracellular matrix preservation during whole liver decellularization. Biomater Adv. 2024:213710.
60. Ghosal K, Ghosh S, Ghosh D, Sarkar K. Natural polysaccharide derived carbon dot based in situ facile green synthesis of silver nanoparticles: Synergistic effect on breast cancer. Int J Biol Macromol. 2020;162:1605-1615.
61. Bélteky P, Rónavári A, Zakupszky D, Boka E, Igaz N, Szerencsés B, et al. Are smaller nanoparticles always better? Understanding the biological effect of size-dependent silver nanoparticle aggregation under biorelevant conditions. Int J Nanomed. 2021; 22:3021-3040.
62. Nishanthi R, Malathi S, Palani P. Green synthesis and characterization of bioinspired silver, gold and platinum nanoparticles and evaluation of their synergistic antibacterial activity after combining with different classes of antibiotics. Mater Sci Eng: C. 2019;96:693-707.
63. Abdellatif AA, Mahmood A, Alsharidah M, Mohammed HA, Alenize SK, Bouazzaoui A, et al. Bioactivities of the green synthesized silver nanoparticles reduced using Allium cepa L aqueous extracts induced apoptosis in colorectal cancer cell lines. J Nanomater. 2022;2022:1-13.
64. Xu Z, Feng Q, Wang M, Zhao H, Lin Y, Zhou S. Green biosynthesized silver nanoparticles with aqueous extracts of ginkgo biloba induce apoptosis via mitochondrial pathway in cervical cancer cells. Front Oncol. 2020;10:575415.
65. Alharbi NS, Alsubhi NS. Green synthesis and anticancer activity of silver nanoparticles prepared using fruit extract of Azadirachta indica. J Radiation Res Appl Sci. 2022;15(3):335-345.
66. Bhavana S, Kusuma C, Gubbiveeranna V, Sumachirayu C, Ravikumar H, Nagaraju S. Green route synthesis of copper oxide nanoparticles using Vitex altissima [L] leaves extract and their potential anticancer activity against A549 cell lines and its apoptosis induction. Inorg Nano-Metal Chem. 2022:1-14.
67. Al Tamimi S, Ashraf S, Abdulrehman T, Parray A, Mansour SA, Haik Y, et al. Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells. Cancer Nanotechnol. 2020;11:1-16.
68. Hsin Y-H, Chen C-F, Huang S, Shih T-S, Lai P-S, Chueh PJ. The apoptotic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Letters. 2008;179(3):130-139.
69. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279(6):L1005-L28.
70. Al-Sheddi ES, Farshori NN, Al-Oqail MM, Al-Massarani SM, Saquib Q, Wahab R, et al. Anticancer potential of green synthesized silver nanoparticles using extract of Nepeta deflersiana against human cervical cancer cells (HeLA). Bioinorganic Chem Appl. 2018;2018.
71. Shafagh M, Rahmani F, Delirezh N. CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53. Iranian J Basic Med Sci. 2015;18(10):993.
72. Tabrez S, Khan AU, Mirza AA, Suhail M, Jabir NR, Zughaibi TA, et al. Biosynthesis of copper oxide nanoparticles and its therapeutic efficacy against colon cancer. Nanotechnol Rev. 2022;11(1):1322-1331.
73. Fu X. Oxidative stress induced by CuO nanoparticles (CuO NPs) to human hepatocarcinoma (HepG2) cells. J Cancer Ther. 2015;6(10):889.
74. Ali K, Saquib Q, Ahmed B, Siddiqui MA, Ahmad J, Al-Shaeri M, et al. Bio-functionalized CuO nanoparticles induced apoptotic activities in human breast carcinoma cells and toxicity against Aspergillus flavus: an in vitro approach. Process Biochem. 2020;91:387-397.
75. Liu Y, Zeng Z, Jiang O, Li Y, Xu Q, Jiang L, et al. Green synthesis of CuO NPs, characterization and their toxicity potential against HepG2 cells. Mater Res Express. 2021;8(1):015011.
76. Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG. The role of nitric oxide in cancer. Cell Res. 2002;12(5):311-320.
77. Stevens EV, Carpenter AW, Shin JH, Liu J, Der CJ, Schoenfisch MH. Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth. Mol Pharma. 2010;7(3):775-785.
78. Hickok JR, Thomas DD. Nitric oxide and cancer therapy: the emperor has NO clothes. Curr Pharma Design. 2010;16(4):381-391.
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