An overview of the therapeutic applications of cinnamon-loaded in nanosystems

Articles in Press

Document Type : Review Paper

Authors

1 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

2 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

3 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

4 Departments of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

5 Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

6 Departments of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/nmj.2025.82728.2066

Abstract

Cinnamon, a spice derived from the Cinnamomum genus, has a rich history of traditional medicinal applications. Its therapeutic potential arises from a diverse array of bioactive compounds exhibiting antioxidant, anti-inflammatory, and antimicrobial properties. However, the inherent properties  of cinnamon, such as poor solubility and instability, have limited its clinical applications. Nanotechnology has emerged as a promising approach to overcome these challenges. By encapsulating cinnamon extract/essential oil within nanoscale carriers, researchers have achieved enhanced bioavailability, solubility, controlled release of its bioactive constituents and therapeutic outcomes. This review comprehensively explores various nano-formulations, to improve the cinnamon’s bioactive compounds delivery for biomedical applications. Preclinical studies have demonstrated the efficacy of cinnamon-based nanomaterials in addressing a range of human diseases, including cancer, diabetes, infections, and neurodegenerative disorders. Despite these promising advancements, further research is imperative to elucidate the precise mechanisms of action, optimize formulations, and conduct accurate clinical trials to translate these findings into effective human therapies. 

Keywords

References

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Nanomedicine Journal

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Available Online from 03 March 2025

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