Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents

Document Type : Research Paper

Authors

1 Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.
Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination of chitosan, PVA, MgCl₂, and GPTMS as a crosslinking agent. Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis characterized the prepared composite scaffold. The composite scaffolds' mechanical properties, bioactivity, biocompatibility, swelling, and degradation were also investigated.
Results: Significant improvements in the mechanical properties were observed in the modified composite compared to those seen in the scaffold without MgCl₂. With an increase in MgCl₂ content, the scaffold's degradation and porosity increased, while its swelling capacity decreased. Bioactivity was also enhanced in the composite following the further addition of MgCl₂.
Conclusion:  In vitro tests for cytotoxicity and MG-63 cell proliferation showed that the composite scaffolds were non-cytotoxic, resulting in better cell adherence and growth on the surface of these scaffolds.  

Keywords

References

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Nanomedicine Journal
Volume 12, Issue 3
July 2025
Pages 507-517

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