Structural and antibacterial properties of Ag/GO wound dressing

Articles in Press

Document Type : Research Paper

Authors

1 Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University Semnan, Iran

2 Department of Biotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran

3 Biomedical Engineering Department, Eyvanekey University, Semnan, Iran

4 Faculty of Physics, Semnan University, Semnan, Iran

5 Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran

6 Institute of Materials Research, Slovak academy of science, Kosice, Slovakia

Abstract

Objective(s): Bioactive wound dressings are essential for preventing infection and accelerating tissue regeneration. Green synthesis offers a sustainable route for producing functional nanomaterials with reduced environmental impact.
Materials and Methods: Silver nanoparticles (Ag NPs) were synthesized using aqueous extract of Mentha pulegium as a natural reducing and stabilizing agent. The Ag NPs were combined with graphene oxide (GO) to form Ag/GO composite nanoparticles (CNPs), which were coated onto medical gauze via a simple, cost‑effective, and scalable immersion method. The products were characterized by X‑ray diffraction (XRD) and elemental mapping, and their antibacterial activities were evaluated against Gram‑positive Staphylococcus aureus and Gram‑negative Escherichia coli.
Results: The synthesized Ag NPs had an average diameter of ~108 nm. XRD patterns revealed the (111) plane of face‑centered cubic Ag and the (002) plane of GO. Elemental analysis confirmed uniform Ag, C, and O distribution on the gauze surface. The Ag/GO‑coated gauze achieved > 99% reduction in bacterial colony counts compared to untreated controls.
Conclusion: Ag/GO‑coated gauze demonstrates excellent antibacterial performance and strong potential as a bioactive wound dressing. This environmentally friendly, scalable approach could aid future developments in infection control and wound management.

Keywords

References

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Nanomedicine Journal

Articles in Press, Accepted Manuscript
Available Online from 03 September 2025

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