Transfersomes-based nanocarriers for anticancer drug delivery: a promising approach

Articles in Press

Document Type : Review Paper

Authors

1 Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

2 Cardiothoracic Imaging Section, Department of Radiology, University of Washington, Seattle, WA, USA

3 Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

4 Faculty of Pharmacy, Eastern Mediterranean University Famagusta, North Cyprus via Mersin 10, Turkey.

5 Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

7 Department of Bio-medical Engineering, School of Engineering, University of Bradford, Bradford, UK

8 Interdisciplinary Research Center in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, UK

9 Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Abstract

Chemotherapy is typically used to treat cancer, but it can have a number of negative side effects. Nanocarrier-based drug delivery systems have gained much interest cancer treatment in recent years due to their advantages compared to conventional delivery systems. Recently, transfersomes (TFs) have been known to be the most outstanding innovative drug delivery systems that make them an attractive carriers for drug administration and cancer therapy. TFs have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic drugs/agents with higher permeation efficiencies, offering a promising alternative to conventional liposomes as an anti-cancer drug delivery method. They are highly interesting for applications that involve controlled release. TFs are being explored as a complex system for drug delivery, with a focus on enhancing local drug penetration. This paper overview the current advancements in transfersomes-encapsulated with anti-cancer drugs for intelligent medication delivery to various cancers. In conclusion, this paper briefly discusses the prospects and problems of transfersomes-based anti-cancer drug delivery.

Keywords

References

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Available Online from 22 September 2025

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