Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride

Document Type : Research Paper


1 Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

2 Nanotechnology Research Centre, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or pH. The objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer matrix.

Materials and Methods:
These nanoparticles were made of the copolymer poly (N-isopropylacrylamide-co-methaçrylic acid) by an aqueous dispersion polymerization process and are responsible for dual sensitivity to temperature and pH. Morphology study with SEM, swelling behavior with Dynamic Light Scattering Technique, in vitro drug release behavior with side-by-side Diffusion Cells were also investigated in this paper. Doxorubicin hydrochloride was used as a model solute.

The study on the release of doxorubicin hydrochloride showed that the release rate was higher at pH 5 than pH 7.4, increased with the increase of temperature. Nevertheless, ionic strength only poses a minor direct effect at higher pH.

Such system may be potentially used as a tumor-targeting doxorubicin hydrochloride delivery in the body.


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