Synthesis and tissue distribution of CoFe2O4 Nanoparticles Coated with DMSA in rats liver

Document Type : Research Paper

Authors

Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Abstract

Objective(s): According to the unique properties of magnetic nanoparticles, their usages in medicine and industry have increased in the last decade. Due to the vital role of liver in the body, the accumulation of CoFe2O4 and CoFe2O4@DMSA was studied.
Materials and Methods:The nanoparticles were synthesized by co-precipitation method and were coated with DMSA. The techniques XRD, TEM, DLS, FTIR, AGFM and UV-Visible spectroscopy were used to characterize the nanoparticles. Nanoparticles were injected intraperitoneally in rat and blood samples were collected from the rats’ heart, at 15 and 30 day post injection. The liver of each rat was removed and kept frozen at -70 oC.
Results:The size of the pure cobalt ferrite and DMSA coated cobalt ferrite nanoparticles were about 10 nm and 12 nm, respectively. The saturation magnetization of CoFe2O4 and CoFe2O4@DMSA nanoparticles were 44.8 and 33 emu/g, respectively. Statistical analysis of the results indicated that cobalt ferrite nanoparticles were accumulated in liver in all groups.
Conclusion: The accumulation of nanoparticles in liver was significantly higher than those of the control group and the level of liver iron accumulation was significantly lower after 30 days of injection in comparison with 15 days post injection in all groups.

Keywords

References

[1] Hatchett DW, Josowicz M. Composites of intrinsically conducting polymers as sensing nanomaterials. J Chem Rev. 2008; 108: 746-769.
[2] Kumar A, Jakhmola A. RNA-mediated fluorescent Q-Pb nanoparticles. Langmuir. 2007; 23: 2915-2918.
[3] Hardman RA. Toxicological review of quantum dots:Toxicity depends on physic-chemical and environmental factors. Environ Health Perspect. 2006; 114: 165-172.
[4] Lie Y, Cheng G, Wang Z, Zhang J, Sun D, Hong G, Ni J. Synthesis and characterization of the Fe3O4@SiO2–Eu(DBM)3phen.Cl3 luminomagnetic microspheres. Materials Letters. 2008; 97: 187-90.
[5] Berry CC, Curtis ASG. Functionalisation of magnetic nanoparticles for applications in biomedicine. J Phys D: Appl Phys. 2003; 36: 198-R200.
[6] Salata OV. Applications of nanoparticles in biology and medicine. J Nanobiotechnology. 2004; 2: 3-8.
[7] Tartaj P, Puerto Morales M, Veinemillas-Verdguer S, Gonzalez-Carreno T, Serna CJ. The preparation of magnetic nanoparticles applications in biomedicine. J Phys D: Appl Phys. 2003; 36: R182–R197.
[8] Berry Catherine C. Possible exploitation of magnetic nanoparticle-cell intraction for biomedical applications. Journal of Materials. 2005; 15: 543-547.
[9] Jain TK, Reddy MK, Morales MK, Leslie-Pelecky DL, Labhasetwar V. Biodistribution, clearance and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm. 2008; 5: 316-327.
[10] Shubayev VI, Pisanic TR, Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Delivery Rev. 2009; 61: 467–477
[11] Iatridi Z, Georgiadou V, Menelaou M, Dendrinou-Samara C, Bokias G. Application of hydrophobically modified water-soluble polymers for the dispersion of hydrophobic magnetic nanoparticles in aqueous media, Dalton Trans. 2014; 43: 8633-43.
[12] Akan JC, Abdulrahman FI, Sodipo OA. and Chiroma, Y.A. Distribution of Heavy Metal in the Liver, Kidney and Meat of Beef, Mutton, Caprine and Chicken From Kaasuwan Shanu Market in Maiduguri Metropolis, Borno State, Nigeria. Research Journal of Applied Sciences, Engineering and Technology. 2010; 2: 743-748.
[13] Badiei K. Measurement of manganese concentrations in serum, liver, heart, muscle, spleen and hair in dromedary camels of Yazd province. Pajouhesh & Sazandegi. 2003; 64: 81-84 (In Farsi).
[14] Amiri GhR, Yousefi MH, Aboulhassani MR, Keshavarz MH, Shahbazi D, Fatahian S, Alahi M  Radar absorption of Ni0.7Zn0.3Fe2O4 nanoparticles. Digest J Nanomaterials Biostructures. 2010; 5: 1025–1031.
[15] Li Xing-Hua, Xu Cai-Ling, Han Xiang-Hua. Synthesis and Magnetic Properties of Nearly Monodisperse CoFe2O4 Nanoparticles Through a Simple Hydrothermal Condition, Nanoscale Res Lett. 2010; 5: 1039–1044.
[16] Sani R, Beitollahi A, Maksimov Yu V, Suzdalev IP. Synthesis, phase formation study and magnetic properties of CoFe2O4 nanopowder prepared by mechanical milling. J Mater Sci. 2007; 42: 2126–2131.
[17] Fatahian S, Shahbazi-Gahrouei D, Pouladian M, Yousefi MH, Amiri GHR, Noori A. Biodistribution and Toxicity assessment of radiolabeled and DMSA coated Ferrite nanoparticles in mice. J. Radioanal. Nucl. Chem. 2012; 293: 915-921.
[18] Varna M, Ratajczak Ph, Ferreira I, Leboeuf Ch, Bousquet G, Janin A. In vivo Distribution of Inorganic Nanoparticles in preclinical Modeles. J Biomater Nanobiotechnol. 2012; 3: 269-279.
[19] Wang J, Chen Y, Chen B, Ding J, Xia G, Gao C, Cheng J, Jin N, Zhou Y, Li X, Tang M, Wang XM. Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice. Int J Nanomedicine. 2010; 5: 861-866.
Nanomedicine Journal
Volume 3, Issue 3
July 2016
Pages 196-201

Files

Share

How to cite

Statistics