The applications of nanotechnology in restorative dentistry: a review study

Document Type : Review Paper


1 Dental Clinic of Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Restorative Dentistry, Shahed University of Medical Sciences, Tehran, Iran

3 Department of Restorative Dentistry, Semnan University of Medical Sciences, Semnan, Iran

4 Department of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran

5 School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Nanotechnology has various applications in restorative dentistry in order to achieve reliable treatment outcomes. The present study aimed to comprehensively review the studies focused on the applications of nano-based materials, technologies, and methods used in restorative dentistry. Related articles were retrieved via searching in databases such as PubMed, Google Scholar, and Scopus. Afterwards, the appropriate references regarding the research subject were assessed, and findings were collected to achieve a comprehensive review study. According to the obtained results, the utilization of nanotechnology in restorative dentistry could yield beneficial outcomes. The dispersion of nano-sized structures in restorative materials could enhance mechanical properties such as diametral and flexural strength and fracture toughness. However, the improvement of the mentioned mechanical properties depends on the type of the nano-sized materials, their content, and type of the additional materials used along with nano-based restorative materials.


1.Ramezanizadeh M, Alhuyi Nazari M, Ahmadi MH, Lorenzini G, Pop I. A review on the applications of intelligence methods in predicting thermal conductivity of nanofluids. J Therm Anal Calorim. 2019: 1-17.
2.Ramezanizadeh M, Ahmadi MA, Ahmadi MH, Alhuyi Nazari M. Rigorous smart model for predicting dynamic viscosity of Al2O3/water nanofluid. J Therm Anal Calorim. 2018; 137(1): 307-316.
3.Ahmadi MH, Ghazvini M, Alhuyi Nazari M, Ahmadi MA, Pourfayaz F, Lorenzini G, Ming T. Renewable energy harvesting with the application of nanotechnology: A review. Int J Energy Res. 2019; 43(4): 1387-1410.
4.Fazel-Ghaziyani M, Shahbazi-Gahrouei D, Pourhassan-Moghaddam M, Baradaran B, Ghavami M. Targeted detection of the cancer cells using the anti-CD24 bio modified PEGylated gold nanoparticles: the application of CD24 as a vital cancer biomarker. J Nanomedicine. 2018; 5(3): 172-179.
5.Mohamadian F, Eftekhar L, Haghighi Bardineh Y. Applying GMDH artificial neural network to predict dynamic viscosity of an antimicrobial nanofluid. Nanomed J. 2018; 5(4): 217-221.
6.Evelyn Roopngam P. Liposome and polymer-based nanomaterials for vaccine applications. Nanomed J. 2019; 6(1): 1-10.
7.Haghighi Bardineh Y, Mohamadian F, Ahmadi MH, Akbarianrad N. Medical and dental applications of renewable energy systems. Int J Low-Carbon Technol. 2018; 13(4): 320-326.
8.Ramezanizadeh M, Alhuyi Nazari M, Ahmadi MH, Açıkkalp E. Application of nanofluids in thermosyphons: A review. J Mol Liq. 2018; 272: 395-402.
9.Tahmasbi S, Mohamadian F, Hosseini S, Eftekhar L. A review on the applications of nanotechnology in orthodontics. Nanomed J. 2019; 6(1): 11-18.
10.Akbarianrad N, Mohammadian F, Alhuyi Nazari M, Rahbani Nobar B. Applications of nanotechnology in endodontic: A Review Nanomed J. 2018; 5(3): 121-126.
11.Ghalandari M, Mirzadeh Koohshahi E, Mohamadian F, Shamshirband S, Chau KW. Numerical simulation of nanofluid flow inside a root canal. Eng Appl Comput Fluid Mech. 2019; 13(1): 254-264.
12.Sadeghzade S, Emadi R. Improving the mechanical and bioactivity of hydroxyapatite porous scaffold ceramic with diopside/forstrite ceramic coating. Nanomed J. 2019; 6(1): 50-54.
13.Karimi Zarchi AA, Amini SM, Jomehfarsangi Z, Mohammadi E, Moosavi Z, Ghadiri Harrati P. A study on the possibility of drug delivery approach through ultrasonic sensitive nanocarriers. Nanomed J. 2018; 5(3): 127-137.
14.Zabihzadeh M, Hoseini-Ghahfarokhi M, Bayati V. Enhancement of radio-sensitivity of colorectal cancer cells by gold nanoparticles at 18 MV energy. Nanomed J. 2018; 5(2): 111-120.
15.Kachoei M, Divband B, Eskandarinejad F, Khatamian M. Deposition of ZnO nano particles on stainless steel orthodontic wires by chemical solution method for friction reduction propose. Res J Pharm Biol Chem Sci. 2015; 6(3): 104-122.
16.Monzavi A, Eshraghi S, Hashemian R, Momen-Heravi F. In vitro and ex vivo antimicrobial efficacy of nano-MgO in the elimination of endodontic pathogens. Clin Oral Investig. 2015; 19(2): 349-356.
17.Walmsley AD. Restorative Dentistry. Elsevier Churchill Livingstone. 2007.
18.Khurshid Z, Zafar M, Qasim S. Advances in Nanotechnology for Restorative Dentistry. Materials (Basel). 2015; 8(2): 717-731.
19.Balhaddad AA, Kansara AA, Hidan D, Weir MD, Xu HHK, Melo MAS. Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials. Bioact Mater. 2019; 4(1): 43-55.
20.Yesilyurt C, Kusgoz A, Bayram M, Ulker M. Initial Repair Bond Strength of a Nano-filled Hybrid Resin: Effect of Surface Treatments and Bonding Agents. J Esthet Restor Dent. 2009; 21(4): 251-260.
21.Schirrmeister JF, Huber K, Hellwig E, Hahn P. Two-year evaluation of a new nano-ceramic restorative material. Clin Oral Investig. 2006; 10(3): 181-186.
22.Saunders SA. Current practicality of nanotechnology in dentistry. Part 1: Focus on nanocomposite restoratives and biomimetics. Clin Cosmet Investig Dent. 2009; 1: 47-61.
23.Kantharia NR, Naik S, Apte S, Kheur MG, Kheur SM, Kale B. Nano ‐ hydroxyapatite and its contemporary applications. J Dent Res Sci Dev. 2014; 1(1): 15-19.
24.Hemalatha, Nagar P. A Comparitive Evaluation of the Effect of Sports and Fruit Drinks on the Surface Roughness of Nanofilled Composite and Light Cure GIC-An In Vitro Study. Int J Clin Pediatr Dent. 11(5): 417-424.
25.Kasraei, S., Malek, M., Khamverdi, Z., Mojtahedi, M. The Efficacy of Riboflavin for Collagen Cross-Linking and Optimizing the Bond Strength of an Etch and Rinse Adhesive System to Dentin. 2017; 9(3): 1-6.
26.Kasraei S, Yarmohammadi E, Farhadian M, Malek M. Effect of Proteolytic Agents on Microleakage of Etch and Rinse Adhesive Systems. Brazilian J Oral Sci. 2017: 17048-17048.
27.Nagano F, Selimovic D, Noda M. Improved bond performance of a dental adhesive system using nano-technology. Biomed Mater Eng. 2009; 19(2-3): 249-257.
28.Atai M, Pahlavan A, Moin N. Nano-porous thermally sintered nano silica as novel fillers for dental composites. Dent Mater. 2012; 28(2): 133-145.
29.F. Foroutan, J. Javadpou, A. khavandi, M. Atai, H. R. Rezaie. Mechanical properties of dental composite materials reinforced with micro and nano-size Al2O3 filler particles. Iran J Mater Sci Eng. 2011; 8(2): 25-33.
30.Korkmaz Y, Gurgan S, Firat E, Nathanson D. Shear Bond Strength of Three Different Nano-Restorative Materials to Dentin. Oper Dent. 2010; 35(1): 50-57.
31.van Dijken JWV, Pallesen U. Four-year clinical evaluation of Class II nano-hybrid resin composite restorations bonded with a one-step self-etch and a two-step etch-and-rinse adhesive. J Dent. 2011; 39(1): 16-25.
32.F. Foroutan, J. Javadpou, A. khavandi, M. Atai, H. R. Rezaie. Mechanical properties of dental composite materials reinforced with micro and nano-size Al2O3 filler particles. Iran J Mater Sci Eng. 2011; 8(2): 25-33. Paula A, Fucio S, Ambrosano G, Alonso R, Sardi J, Puppin-Rontani R. Biodegradation and Abrasive Wear of Nano Restorative Materials. Oper Dent. 2011; 36(6): 670-677.
34.Turssi CP, Ferracane JL, Ferracane LL. Wear and fatigue behavior of nano-structured dental resin composites. J Biomed Mater Res Part B Appl Biomater. 2006; 78B(1): 196-203.
35.Tian M, Gao Y, Liu Y, Liao Y, Hedin NE, Fong H. Fabrication and evaluation of Bis-GMA/TEGDMA dental resins/composites containing nano fibrillar silicate. Dent Mater. 2008; 24(2): 235-243.
36.Chen M-H, Chen C-R, Hsu S-H, Sun S-P, Su W-F. Low shrinkage light curable nanocomposite for dental restorative material. Dent Mater. 2006; 22(2): 138-145.
37.Schirrmeister JF, Huber K, Hellwig E, Hahn P. Two-year evaluation of a new nano-ceramic restorative material. Clin Oral Investig. 2006; 10(3): 181-186.
38.Moheet IA, Luddin N, Ab Rahman I, Masudi SM, Kannan TP, Abd Ghani NRN. Evaluation of mechanical properties and bond strength of nano-hydroxyapatite-silica added glass ionomer cement. Ceram Int. 2018; 44(8): 9899-9906.